Does the Severity of Overactive Bladder Symptoms Correlate with Risk for Female Sexual Dysfunction?

Juliato, Cássia Raquel Teatin; Melotti, Iane Glauce Ribeiro; Santos, Luiz Carlos; Britto, Luiz Gustavo Oliveira; Riccetto, Cássio

doi:10.1016/j.jsxm.2017.05.005

Cited by 17 publications

(13 citation statements)

References 22 publications

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“…Although Mirabegron has been demonstrated to be effective and safe in the treatment of OAB in naïve patients or in those refractory to anticholinergics [21], to date data related to an eventual effect on sexual dysfunction are completely lacking. The results in our study may be in favour of a causal relationship between urinary symptoms and sexual dysfunction in women [22]. Since Mirabegron induced improvements in all OAB symptoms and a complete urinary continence in a large proportion of patients, we retain that the positive effect on sexual dysfunction could be attributed to an indirect effect by the urologic clinical and QoL amelioration.…”

Section: Discussionmentioning

confidence: 58%

The impact of Mirabegron on sexual function in women with idiopathic overactive bladder

et al. 2019

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BackgroundOveractive bladder (OAB) can frequently exert a negative effect on female sexual function. Mirabegron, a β3 receptor agonist, improves OAB symptoms, but there are very few information about its role on female sexual dysfunction (FSD). Aim of the study was to assess the impact of Mirabegron on FSD in women affected by OAB.MethodsFifty sexually active women suffering from idiopathic OAB were included in the study. Patients were assessed by means of a urogynecologic physical examination and were asked to complete the 3-day voiding diary, the International Consultation on Incontinence Questionnaire- Short Form (ICIQ-SF), the Female Sexual Function Index (FSFI) questionnaire and VAS, before and 12 weeks after treatment with Mirabegron. In addition, at the same time points, patients underwent uroflowmetry with the measurement of post- void residual volume (PVR).ResultsAt baseline all patients were affected by OAB symptoms, with 49/50 patients (98%) presenting with FSD. At 12- weeks follow- up, OAB symptoms improved significantly in all patients, with 59.5% of subjects achieving a complete urinary continence. FSFI Total Score significantly improved in 42/50 patients (84%) from 18.9 ± 4.3 to 21.8 ± 4.5 (p < 0.0001). Sixteen cases (32%) presented with no FSD. Also mean ± SD scores of ICIQ-SF and VAS significantly improved (from 17.1 ± 5 to 7.9 ± 4.8 and from 3.9 ± 1.2 to 6.9 ± 1.2 respectively, p < 0.000).ConclusionsMirabegron not only is able to control urinary symptoms in women with OAB, but also induces a significant improvement in their sexual life.

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Section: Discussionmentioning

confidence: 58%

The impact of Mirabegron on sexual function in women with idiopathic overactive bladder

et al. 2019

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“…Several studies have underlined that OAB drastically reduces quality of life because of its negative influence on many aspects of patients' lives, including social, physical, and psychological well-being, and work productivity [42][43][44][45]. Moreover, both sexual desire and the capacity to reach an orgasm through penetration are impaired in female patients with OAB, thus affecting their sexual health [46,47]. Not surprisingly, many papers have reported that urinary symptoms can cause a huge psychological burden, likely to affect mental and sexual health through the production of negative emotions [47][48][49][50][51][52].…”

mentioning

confidence: 99%

“…Moreover, both sexual desire and the capacity to reach an orgasm through penetration are impaired in female patients with OAB, thus affecting their sexual health [46,47]. Not surprisingly, many papers have reported that urinary symptoms can cause a huge psychological burden, likely to affect mental and sexual health through the production of negative emotions [47][48][49][50][51][52]. Although OAB is frequently associated with female sexual dysfunction (FSD), its real impact on sexual function in women has been evaluated only in a few studies [42,[45][46][47][48][49][50][51][52][53][54][55][56].…”

mentioning

confidence: 99%

“…Not surprisingly, many papers have reported that urinary symptoms can cause a huge psychological burden, likely to affect mental and sexual health through the production of negative emotions [47][48][49][50][51][52]. Although OAB is frequently associated with female sexual dysfunction (FSD), its real impact on sexual function in women has been evaluated only in a few studies [42,[45][46][47][48][49][50][51][52][53][54][55][56]. In this regard, one of the most frequently used questionnaires in the literature to evaluate sexual dysfunctions related to different diseases is the Female Sexual Function Index (FSFI) [57][58][59][60].…”

mentioning

confidence: 99%

“…Data obtained through the use of this instrument underline that much more women with OAB report sexual dysfunction than the general, healthy female population without urinary symptoms [54,55]. Moreover, in postmenopausal women, there is an association between severity of OAB symptoms and worsening sexu-al function, mainly in the domains of arousal, lubrication, orgasm, and pain [47,[61][62][63][64]. In this regard, the studies by Zhu et al [38] and Hakimi et al [39] confirm that women in menopausal age with OAB report lower scores in all sub-domains of sexual function than women who do not suffer from OAB.…”

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confidence: 99%

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A comparison of sacral neuromodulation vs. transvaginal electrical stimulation for the treatment of refractory overactive bladder: the impact on quality of life, body image, sexual function, and emotional well-being

Rosa

Platania²,

Ciebiera

et al. 2019

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Overactive bladder syndrome (OAB) is defined by the presence of urinary urgency, with or without urge incontinence, usually accompanied by an increase in urinary frequency and nocturia in the absence of urinary tract infections (UTI) or other diseases. The overall prevalence of OAB symptoms in the female population is reported to be 16.6% and increases with advancing age and menopause. The aetiology of OAB is not fully understood and is likely to affect a heterogeneous population of patients due to changes to their central and peripheral nervous systems. Although OAB is frequently associated with female sexual dysfunction (FSD), its real impact on sexual function in women has been evaluated only in a few studies. The first line of treatment for OAB includes behavioural modification and physical therapy, either as monotherapies or in combination. Many patients who have not had success in managing their symptoms with more conservative therapies may decide to resort to third-line treatments for refractory OAB. These treatments include neuromodulation therapies, particularly transvaginal electrical stimulation (TES) and sacral neuromodulation (SN). The aim of this short commentary is to provide an overview of the effectiveness of these treatments and of their impact on quality of life, body image, sexual function, and emotional well-being.

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The Intersection of Female Sexual Function and Overactive Bladder

Shoureshi,

Eilber

2023

Curr Bladder Dysfunct Rep

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Purpose of Review In this review, we discuss the available literature regarding the intersection of female sexual function and overactive bladder (OAB). Specifically, this review includes how OAB and its treatments affect female sexual function and quality of life. Recent Findings Women suffering from overactive bladder have worse sexual function, and there are multiple prospective studies evaluating sexual function before and after overactive bladder treatment. Summary There is a growing body of evidence demonstrating that traditional overactive bladder treatments not only improve OAB but can also improve sexual function.

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Does the Severity of Overactive Bladder Symptoms Correlate with Risk for Female Sexual Dysfunction?

Cited by 17 publications

References 22 publications

The impact of Mirabegron on sexual function in women with idiopathic overactive bladder

The impact of Mirabegron on sexual function in women with idiopathic overactive bladder

A comparison of sacral neuromodulation vs. transvaginal electrical stimulation for the treatment of refractory overactive bladder: the impact on quality of life, body image, sexual function, and emotional well-being

The Intersection of Female Sexual Function and Overactive Bladder

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