Does the preoperative neutrophil-to-lymphocyte ratio have a prognostic value in aneurysmal bone cysts?

Abstract

Objectives The aim of this study was to evaluate the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-tomonocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in aneurysmal bone cysts (ABCs). Patients and methods Between February 2001 and August 2019, a total of 86 patients (44 males, 42 females; mean age: 21.5±15.2 years; range, 2 to 73 years) with a histologically confirmed diagnosis of ABCs who did not receive cancer treatment previously and had a minimum follow-up period of 24 months were retrospectively analyzed. Data including age, sex, side, tumor location, pre-treatment complete blood count analysis results, preferred surgical method, follow-up period, presence of recurrence, and date of recurrence were recorded. Preoperative NLR, LMR and PLR values were calculated in all patients. Results The mean follow-up was 56.7±13.5 (range, 24 to 179) months. Forty-one (47.7%) ABCs were located in the lower extremities, 36 (41.8%) in the upper extremities, and nine (10.4%) in the pelvic girdle. A statistically significant difference was detected in the NLR values according to recurrence status (p=0.023). The PLR and LMR values were not significant for area under the curve, while NLR values were significant for recurrence. The cut-off value was determined as 2.054. Those with an NLR of ≥2.054 were found to have a 4.561-fold higher risk of recurrence than those with an NLR of <2.054 (odds ratio [OR]=4.561). Conclusion Our study results suggest that NLR, which is the pre-treatment inflammatory index, is a prognostic factor in patients with ABCs. Although NLR alone is not decisive in patients with elevated NLR, it can be used to evaluate the clinical prognosis and recommend an appropriate treatment strategy.

Cortical hypertrophy in intramuscular hemangioma mimicking bone tumor

“…[ 14 ] In these lesions, ethanol is considered one of the most effective sclerosing agents with low recanalization rates. [ 14 , 15 ] In our case, sclerotherapy was applied using alcohol, and the patien’'s pain symptoms regressed.…”

A Retrospective Comparative Evaluation of Selected Blood Cell Ratios, Acute Phase Proteins, and Leukocyte Changes Suggestive of Inflammation in Cats

“…These white blood cell populations are involved in the patho-mechanisms of inflammation and stress disorders at the same time [ 8 , 9 ]. In humans, NLR, MLR, and platelet-to-lymphocyte ratio (PLR) values were studied as inflammatory markers in various conditions for diagnostic and prognostic purposes [ 2 , 8 , 10 , 11 , 12 , 13 , 14 ]. High values of NLR and MLR were considered accurate additional markers in the diagnosis of acute coronary syndrome [ 8 ].…”

“…High values of NLR and MLR were considered accurate additional markers in the diagnosis of acute coronary syndrome [ 8 ]. The NLR value was found to be positively correlated with the severity of the clinical course in critically ill patients [ 2 ], and increased values were associated with a higher risk of recurrence of aneurysmal bone cysts [ 12 ]. In patients with lymphadenopathy, MLR values were higher in those diagnosed with lymphoma [ 10 ].…”