Does the Pisa syndrome affect postural control, balance, and gait in patients with Parkinson's disease? An observational cross-sectional study

Geroin, Christian; Smania, Nicola; Schena, Federico; Dimitrova, Eleonora; Verzini, Elisabetta; Bombieri, Federica; Nardello, Francesca; Tinazzi, Michèle; Gandolfi, Marialuisa

doi:10.1016/j.parkreldis.2015.04.020

Cited by 51 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Central mechanisms refer to basal ganglia dysfunction, abnormal sensorimotor integration, and cognitive dysfunctions affecting the body schema perception and postural control . PS can be seen after neuroleptic exposure or in PD after the introduction/withdrawal or modification (increase/decrease) of dopaminergic and nondopaminergic medications (Table ) .…”

Section: Pathophysiology Of Psmentioning

confidence: 99%

Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management

et al. 2016

Self Cite

View full text Add to dashboard Cite

Pisa syndrome was first described in 1972 in patients treated with neuroleptics. Since 2003, when it was first reported in patients with Parkinson's disease (PD), Pisa syndrome has progressively drawn the attention of clinicians and researchers. Although emerging evidence has partially clarified its prevalence and pathophysiology, the current debate revolves around diagnostic criteria and assessment and the effectiveness of pharmacological, surgical, and rehabilitative approaches. Contrary to initial thought, Pisa syndrome is common among PD patients, with an estimated prevalence of 8.8% according to a large survey. Furthermore, it is associated with the following specific patient features: more severe motor phenotype, ongoing combined pharmacological treatment with levodopa and dopamine agonists, gait disorders, and such comorbidities as osteoporosis and arthrosis. The present literature on treatment outcomes is scant, and the uneven effectiveness of specific treatments has produced conflicting results. This might be because of the limited knowledge of Pisa syndrome pathophysiology and its variable clinical presentation, which further complicates designing randomized clinical trials on this condition. However, because some forms of Pisa syndrome are potentially reversible, there is growing consensus on the importance of its early recognition and the importance of pharmacological adjustment and rehabilitation. © 2016 International Parkinson and Movement Disorder Society.

show abstract

Section: Pathophysiology Of Psmentioning

confidence: 99%

Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…The movement of COG and COP is used in humans to describe stability and normal and abnormal locomotion (Whittle, 1997; Tesio et al, 1998a; Cornwall and McPoil, 2000; Detrembleur et al, 2000) and to quantify changes due to aging (Park et al, 2013), orthopedic injury (Tesio et al, 1998b; Park et al, 2016) and neurologic disease (Massaad et al, 2004; Geroin et al, 2015). It uniquely reflects the synthesis of forces generated by the subject to generate continuous data from performance of a simple task — walking.…”

Section: Discussionmentioning

confidence: 99%

Quantifying center of pressure variability in chondrodystrophoid dogs

Blau

Gorney

Dohse

et al. 2017

The Veterinary Journal

View full text Add to dashboard Cite

The center of pressure (COP) position reflects a combination of proprioceptive, motor and mechanical function. As such, it can be used to quantify and characterize neurologic dysfunction. The aim of this study was to describe and quantify the movement of COP and its variability in healthy chondrodystrophoid dogs while walking to provide a baseline for comparison to dogs with spinal cord injury due to acute intervertebral disc herniations. Fifteen healthy adult chondrodystrophoid dogs were walked on an instrumented treadmill that recorded the location of each dog’s COP as it walked. Center of pressure (COP) was referenced from an anatomical marker on the dogs’ back. The root mean squared (RMS) values of changes in COP location in the sagittal (y) and horizontal (x) directions were calculated to determine the range of COP variability. Three dogs would not walk on the treadmill. One dog was too small to collect interpretable data. From the remaining 11 dogs, 206 trials were analyzed. Mean RMS for change in COPx per trial was 0.0138 (standard deviation, SD 0.0047) and for COPy was 0.0185 (SD 0.0071). Walking speed but not limb length had a significant effect on COP RMS. Repeat measurements in six dogs had high test retest consistency in the x and fair consistency in the y direction. In conclusion, COP variability can be measured consistently in dogs, and a range of COP variability for normal chondrodystrophoid dogs has been determined to provide a baseline for future studies on dogs with spinal cord injury.

show abstract

“…So far, the presumed effect of posture misalignments in postural control (i.e., Pisa syndrome) has been partially elucidated. Recent data indicate that the Pisa syndrome is associated with abnormal postural responses to maintain postural uprightness with significantly higher body sway velocity in the anteroposterior and mediolateral directions [44]. It means that a misalignment of posture may negatively influence postural and balance responses in PD patients and may be further comprised in patients unaware of their misalignment.…”

Section: Movement Strategiesmentioning

confidence: 99%

“…Finally, PD patients with posture misalignment might rely mostly on visual inputs to control their posture and postural reactions [44].…”

Section: Sensory Strategiesmentioning

confidence: 99%

Postural Control in Individuals with Parkinson’s Disease

Gandolfi¹,

Valè²,

Filippetti³

et al. 2019

Different Areas of Physiotherapy

Self Cite

View full text Add to dashboard Cite

Parkinson's disease is the second most common neurodegenerative disorder in the elderly population. It is a complex, progressive, multisystem disease associated with motor and nonmotor impairments. Postural instability is a crucial component of functional mobility, often overlooked by both clinicians and patients with Parkinson's disease. It is a refractory drug complication for which rehabilitation is the most effective nonpharmacological aid. However, many interventions are based on empirical experience. Improving knowledge on the pathophysiology of postural control disorders is crucial to understand the multifaceted components affected and thus design specific rehabilitation protocols. This chapter intends to offer a comprehensive overview of the current knowledge on this topic starting from the pathophysiology of postural control disorders occurring in various ecological conditions to the most innovative multidisciplinary rehabilitation approaches.

show abstract

Does the Pisa syndrome affect postural control, balance, and gait in patients with Parkinson's disease? An observational cross-sectional study

Cited by 51 publications

References 22 publications

Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management

Pisa syndrome in Parkinson's disease: An integrated approach from pathophysiology to management

Quantifying center of pressure variability in chondrodystrophoid dogs

Postural Control in Individuals with Parkinson’s Disease

Contact Info

Product

Resources

About