Does the neobladder filling modulate soleus H reflex?

Palleschi, Giovanni; Conte, Antonella; Pastore, Antonio Luigi; Salerno, Gisela Rosa Franco; Morgia, Giuseppe; Giannantoni, Antonella; Berardelli, Alfredo; Carbone, Antonio

doi:10.1016/j.clinph.2013.06.027

Cited by 5 publications

(2 citation statements)

References 5 publications

(8 reference statements)

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“…This study extends previous investigations on the same topic (Inghilleri et al 2001;Carbone et al 2002;Palleschi et al 2014;Serrao et al 2014). The main results we obtained can be summarized as follows: (i) both NWR and its related pain perception were reduced only in the upper limbs; conversely, the H-reflex was inhibited in both limbs; (ii) NWR pain-related perception (NRS) was decreased in males in both limbs, while in females, no significant changes were observed in lower limbs; and (iii) no effects were found on the CSP duration.…”

Section: Discussionsupporting

confidence: 60%

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability

et al. 2015

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To verify whether high level of bladder distension may counteract the inhibitory effect of descending pathways on sacral spinal cord neurons and to investigate which spinal circuitries are possibly involved in such a viscero-somatic interaction. Nociceptive withdrawal reflex (NWR), cutaneous silent period (CSP), and H-reflex were recorded in both lower and upper limbs of twenty-eight healthy subjects. Subjects were examined during baseline (empty bladder, no voiding desire), high level of bladder filling (urgency desire), and control (empty bladder, no voiding desire) sessions. Results showed that the NWR and its related pain perception were reduced in the upper limbs, while only a pain perception reduction in males was observed in the lower limbs. The H-reflex was inhibited in both limbs. No effects were found on the CSP duration. The decrease in both the NWR and its related pain perception in the upper limbs confirms the presence of a bladder distension-induced descending inhibitory modulation on nociception at spinal level. The lack of a similar inhibitory effect in the lower limbs suggests that excitatory nociceptive inputs from bladder afferents counterbalance the inhibitory effect on sacral spinal cord. The lack of the descending inhibitory effect may be a mechanism aimed at forcing the micturition phase to avoid bladder damage caused by bladder sovradistension.

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Section: Discussionsupporting

confidence: 60%

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability

et al. 2015

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“…Neurophysiological techniques can provide insights into the pathophysiology of bladder dysfunction in neurological conditions. In healthy subjects, previous studies showed that bladder filling inhibits soleus Hoffmann reflex (H reflex) size, and the decrease is thought to be due to the effect of bladder afferents input on spinal motor neurons [ 4 ]. In patients with neurogenic bladder, changes in the H reflex size depend on whether the central nervous system lesion lies in a suprapontine or spinal site.…”

Section: Introductionmentioning

confidence: 99%

Intradetrusorial Botulinum Toxin in Patients with Multiple Sclerosis: A Neurophysiological Study

Conte

Giannantoni

Gubbiotti

et al. 2015

Toxins

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Patients with multiple sclerosis (MS) often complain of urinary disturbances characterized by overactive bladder syndrome and difficulties in bladder emptying. The aim of the study was to investigate the pathophysiology of bladder dysfunction and the neurophysiological effects of intradetrusorial incobotulinum toxin A (BoNT/A) in patients with MS having both brain and spinal MS-related lesions. Twenty-five MS patients with neurogenic detrusor overactivity (NDO) underwent clinical evaluation and soleus Hoffmann reflex (H reflex) study during urodynamics. Of the 25 patients, 14 underwent a further session one month after intradetrusorial BoNT/A injection. Eighteen healthy subjects acted as the control. In healthy subjects, the H reflex size significantly decreased at maximum cystometric capacity (MCC), whereas in MS patients with NDO, the H reflex remained unchanged. In the patients who received intradetrusorial BoNT/A, clinical and urodynamic investigations showed that NDO improved significantly. Volumes at the first, normal and strong desire to void and MCC increased significantly. Despite its efficacy in improving bladder symptoms and in increasing volumes for first desire, normal and strong desire to void, BoNT/A left the H reflex modulation during bladder filling unchanged. In the MS patients we studied having both brain and spinal MS-related lesions, the H reflex size remained unchanged at maximum bladder filling. Since this neurophysiological pattern has been previously found in patients with spinal cord injury, we suggest that bladder dysfunction arises from the MS-related spinal lesions. BoNT/A improves bladder dysfunction by changing bladder afferent input, as shown by urodynamic findings on bladder filling sensations, but its effects on H reflex modulation remain undetectable.

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Initial Experience with Intracorporeal Laparoscopic Radical Cystectomy and Detaenial Sigmoid Neobladder Reconstruction

Chen

et al. 2021

European Urology

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Does the neobladder filling modulate soleus H reflex?

Cited by 5 publications

References 5 publications

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability

Effect of high level of bladder filling on spinal nociception and motoneuronal excitability

Intradetrusorial Botulinum Toxin in Patients with Multiple Sclerosis: A Neurophysiological Study

Initial Experience with Intracorporeal Laparoscopic Radical Cystectomy and Detaenial Sigmoid Neobladder Reconstruction

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