Does the method of treatment affect the outcome in soft-tissue sarcomas of the adductor compartment?

Pradhan, A.; Yc, Cheung; Grimer, R. J.; Abudu, A.; Peake, D.; Ferguson, Peter C.; Griffin, Anthony M.; Wunder, Jay S.; O’Sullivan, Brian; Hugate, Ronald R.; Sim, Franklin H.

doi:10.1302/0301-620x.88b11.17424

Cited by 19 publications

(19 citation statements)

References 31 publications

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“…Results of both studies are comparable to those reporting sarcomas in other anatomic regions. 14 The rate of major complications in our study (26%) was lower than in others (36% 7 and 43% 8 ). Nonetheless, comparisons should be interpreted with caution, as the grading system for complications was not the same.…”

Section: Discussioncontrasting

confidence: 69%

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Surgical Outcome of Soft Tissue Sarcomas of the Adductor Compartment

Rüdiger

Ngan

Choong

2009

J Orthop Surg (Hong Kong)

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Purpose. To review outcomes and complications of 25 consecutive patients with soft tissue sarcomas in the adductor compartment. Methods. Records of 11 men and 14 women aged 20 to 83 (mean, 56) years who underwent resection for soft tissue sarcomas in the adductor compartment were reviewed. Two of the patients had undergone inadequate resection of the tumour elsewhere. No patient had metastases. 20 and 2 patients underwent neo-adjuvant and postoperative radiotherapy, respectively. The interval between radiotherapy and surgery was at least 3 weeks. No neo-adjuvant chemotherapy was given. 24 patients underwent limb salvage surgery and one had external hemipelvectomy. 21 patients had direct wound closure; in 4 a microsurgical free flap was used. Results. The overall survival rate was 81% and 72% at 3 and 5 years, respectively, and remained unchanged until the end of follow-up. Four patients died from 2009;17(3):284-7 2009;17(3):284-7 pulmonary metastases and one died from liver metastases. One patient had local recurrence, and 7 (26%) developed major complications. Five patients underwent revision surgery. Conclusion. Good survival and local control rates can be achieved in patients with soft tissue sarcomas in the adductor compartment using limb salvage and radiotherapy.

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Section: Discussioncontrasting

confidence: 69%

“…Wound complications after resections are frequent and can afflict up to 36% of the patients. 1,7,8 We reviewed outcomes and complications of 25 consecutive patients with soft tissue sarcomas in the adductor compartment. 3 .…”

Section: Introductionmentioning

confidence: 99%

Surgical Outcome of Soft Tissue Sarcomas of the Adductor Compartment

Rüdiger

Ngan

Choong

2009

J Orthop Surg (Hong Kong)

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“…It has been shown that the outcome of patients with STS indeed does differ even among international highvolume centers. 26,27 In conclusion the presented results support our hypothesis that preoperative IMRT may lead to a reduction of wound complication rates compared to that after postoperative and mainly preoperative non-IMRT techniques.…”

Section: Discussionsupporting

confidence: 81%

Preoperative IMRT for soft-tissue sarcoma of the extremities and trunk: low rate of wound complications

Studer

Glanzmann

Maduz

et al. 2018

Current Orthopaedic Practice

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Background: The Canadian prospective randomized NCIC SR2 trial tested the sequence of radiation and surgery for extremity soft-tissue sarcoma. The trial was conducted in the era before intensity-modulated radiation therapy (IMRT) was clinically available. Similar disease control after preoperative and postoperative non-IMRT was found. However, the preoperative non-IMRT arm showed significantly less (persisting) late-term effects but increased (transient) wound complication rates compared to the postoperative non-IMRT arm (35% vs. 17%, P = 0.01). Consequently based on these results, preoperative radiation therapy was considered the preferred approach. Currently IMRT, with its option for highly conformal dose distribution that translates into better normal tissue sparing, is used as the general standard for sarcoma radiation therapy in most patients. Our hypothesis was that a lower wound complication rate after preoperative radiation therapy might be achievable in the IMRT era. Methods: We prospectively assessed our preoperative IMRT cohort (n=67 consecutive patients) treated between March 2008 and March 2016 with respect to wound complication rates. Results: Fourteen of 67 (21%) externally referred patients with recurrent (n=1) or incompletely resected disease (n=13), and 53 treatment-naive patients underwent planned preoperative radiation after core biopsy. After mean/median 7.3/7 wk (3-12 wk), complete tumor resection was performed. Secondary revision was required in five of 67 (i.e., wound complication rate of 7%). Two local failures were observed so far. Conclusions: The presented results support our hypothesis that preoperative IMRT may lead to a reduced wound complication rate compared to that after postoperative and mainly preoperative non-IMRT techniques.

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“…16,19,22,23 It has been validated, and its popularity relates to its ease of use. No preoperative TESS results were available.…”

Section: Discussionmentioning

confidence: 99%

Functional and Oncological Outcome Following Marginal Excision of Well-Differentiated Forearm Liposarcoma With Nerve Involvement

Kemp

Hinsley

Gwilym

et al. 2011

The Journal of Hand Surgery

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Does the method of treatment affect the outcome in soft-tissue sarcomas of the adductor compartment?

Cited by 19 publications

References 31 publications

Surgical Outcome of Soft Tissue Sarcomas of the Adductor Compartment

Surgical Outcome of Soft Tissue Sarcomas of the Adductor Compartment

Preoperative IMRT for soft-tissue sarcoma of the extremities and trunk: low rate of wound complications

Functional and Oncological Outcome Following Marginal Excision of Well-Differentiated Forearm Liposarcoma With Nerve Involvement

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