Does the Emptier Have No Clothes? Diabetes, Gastric Emptying, and the Syndrome of Gastroparesis

Pasricha, Pankaj J.

doi:10.1016/j.cgh.2014.10.027

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The Concept Of Gastroparesis1

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Cited by 5 publications

(1 citation statement)

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“…The diagnosis of gastroparesis is made based on the demonstration of delayed gastric emptying in a patient with typical symptoms in the absence of mechanical obstruction. Disorders of gastric motility in gastroparesis do not always correlate with the se verity of symptoms, although this seems to depend on the quality of the diagnostic method used [5][6][7][8]. The most common clinical symptom is nausea, which occurs in more than 90% of patients [4].…”

Section: The Concept Of Gastroparesismentioning

confidence: 99%

Gastroparesis in the intensive care unit

Stojek¹,

Jasiński²

2021

ait

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Section: The Concept Of Gastroparesismentioning

confidence: 99%

Gastroparesis in the intensive care unit

Stojek¹,

Jasiński²

2021

ait

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Diabetic Neuropathy

Vas¹,

Mahdi-Rogers²

2019

Limb Salvage of the Diabetic Foot

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Current and Emerging Medical Therapies for Gastroparesis

Zhao

Mashimo

2015

Curr Treat Options Gastro

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Gastroparesis likely involves various pathophysiological disorders and is increasingly prevalent as complications of surgeries, medications, and chronic diabetes. Key to diagnosis is evidence of delayed gastric emptying, generally based on standardized scintigraphy, and ruling out distal obstruction or other dysmotilities. Initial medical management includes reviewing potentially exacerbating medications and ruling out other reversible causes, achieving tighter glucose control in diabetics, and implementing dietary and lifestyle changes. While current available medications are limited, symptomatic control is aimed at improving gastric emptying, alleviating nausea and vomiting, and treating associated abdominal pain. Other potential therapies are aimed at reducing acid production, improving gastric accommodation or pyloric dysfunction, and treating bacterial overgrowth. Future studies should be aimed toward identification of subpopulations of gastroparetics who are better responders to the various medications based on differences in underlying pathophysiology and adopting standardized study end point measures that may allow for comparisons across trials. This chapter will review current treatment options, upcoming promising medications, and some of the hurdles in advancing the field forward.

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Does the Emptier Have No Clothes? Diabetes, Gastric Emptying, and the Syndrome of Gastroparesis

Cited by 5 publications

References 32 publications

Gastroparesis in the intensive care unit

Gastroparesis in the intensive care unit

Diabetic Neuropathy

Current and Emerging Medical Therapies for Gastroparesis

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