Does the count after inguinofemoral lymphadenectomy in vulvar cancer correlate with outcome?

Baiocchi, Glauco; Cestari, Flávia Munhoz; Rocha, Rafael Malagoli; Faloppa, Carlos Chaves; Kumagai, Lillian Yuri; Fukazawa, Elza Mieko; Badiglian-Filho, Levon; Cestari, L. A.; Rodrigues, Iara S.; Lavorato-Rocha, André Mourão; Maia, Beatriz M.; Soares, Fernando Augusto

doi:10.1016/j.ejso.2013.02.012

Cited by 21 publications

(17 citation statements)

References 30 publications

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“…[7][8][9][10][11][12][13][14][15] The results of this study also verified that LN involvement was clearly confirmed as being the most important prognostic factor for both DFS. In the multivariate analysis, LN involvement was the independent prognostic factor regarding DFS in the current study.…”

supporting

confidence: 71%

The Impact of Tumor and Lymph Node Characteristics on Disease Free Survival in Squamous Cell Vulvar Cancer.

Cırık¹

2016

UHOD

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We aimed to determine the prognostic significance of tumor and lymph node (LN) characteristics on disease free survival (DFS) in patients who underwent surgery for squamous cell vulvar carcinoma. A total of 94 patients who underwent vulvar surgery and groin dissection were included. The impact of clinicopathologic variables such as age, body mass index, tumor size, tumor depth, total and metastatic lymph node number on DFS were assessed. The estimates of survival were determined with Kaplan-Meier and log rank analysis. In the univariate analysis; age, body mass index, tumor size, tumor location, total LN number, metastatic LN number and adjuvant therapy did not have impact on DFS. The median number of removed LNs was 21. Although removal of higher number of lymph nodes did not improved the DFS, patients who had ≤ 3 metastatic LNs had better 2-year DFS rate compared to those with >3 metastatic LNs (71.8% vs 40.0%; p= 0.042, respectively). In the multivariate analysis, both the depth of tumor invasion and LN involvement were the independent predictors of DFS. Additionally, in stage III disease, patients receiving adjuvant therapy had significantly less locoregional recurrence compared to those who did not receive. The presence of LN metastasis and increased tumor depth (> 3 mm) are poor prognostic factors for DFS in squamous cell vulvar cancer. Although the number of lymph nodes removed was not correlated with DFS, patients who had ≤ 3 metastatic LNs had better DFS compared to those with > 3 LNs. Keywords: Vulvar cancer, lymph node, disease free survival, recurrence ÖZET Skuamöz Hücreli Vulva Kanserinde Tümör ve Lenf Nodu Özelliklerinin Hastalıksız Sağkalıma EtkisiBu çalışmada, skuamöz hücreli vulva kanseri için cerrahi yapılan hastalarda tümör ve lenf nodu (LN) özelliklerinin hastalıksız sağkalıma (DFS) etkisini incelemek amaçlandı. Vulvar cerrahi ve lenf nodu diseksiyonu yapılan toplam 94 hasta çalışmaya dahil edildi. Yaş, vücut kitle indeksi, tümör boyutu, tümör derinliği, total ve metastatik LN sayısı gibi klinikopatolojik değişkenlerin DFS'ye etkisi araştırıldı.Sağkalım analizleri ise Kaplan-Meier ve log rank analizi ile yapıldı. Univaryant analizine göre, yaş, vücut kitle indeksi, tümör boyutu ve yeri, toplam LN sayısı, metastatik LN sayısı ve adjuvan tedavi DFS üzerine etkili bulunmadı. Ortalama olarak 21 tane LN çıkarıldı. Ortalamadan fazla lenf nodu çıkarılması DFS üzerine etkili olmasa da, 3 ve daha az metastatik LN çıkarılan hastalar, 3'den fazla metastatik LN çıkarılanlardan daha iyi 2-yıllık-DFS'ye sahip bulundu (sırasıyla, %71.8 ve %40.0; p= 0.042). Multivaryant analizde, hem tümör derinliği hem de LN tutulumu DFS'nin bağımsız prediktörleri idi. Ek olarak, evre III hastalıkta, adjuvan tedavi alan hastalar almayanlara göre daha az lokal (perineal ve kasık) nüksüne sahip idi. Lenf nodu metastazı ve artmış tümör derinliği (> 3 mm), skuamöz hücreli vulva kanseri için kötü prognostic faktörlerdir. Çıkarılan LN sayısı ile 2-yıllık-DFS korele olmasa da evre III hastalarda, 3 ve daha az metastatik LN...

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supporting

confidence: 71%

The Impact of Tumor and Lymph Node Characteristics on Disease Free Survival in Squamous Cell Vulvar Cancer.

Cırık¹

2016

UHOD

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“…Other studies have found that increasing numbers of affected lymph nodes are related to a worse prognosis. 17,22,26 In the present study, metastatic infiltration in the inguinal lymph nodes was found to be associated with poor prognosis in the univariable analysis.…”

Section: Discussionsupporting

confidence: 50%

Study of Biomolecular and Clinical Prognostic Factors in Patients With Cancer of the Vulva Undergoing Surgical Treatment

Zanvettor

Filho

Soares

et al. 2014

Int J Gynecol Cancer

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“…This could be partly explained that a few patients in our cohort received adjuvant treatment (Table 1). In addition, a large population based analysis by Baiocchi et al [10] did not find any benefit of more than 12 resected LNs per patient in nodenegative tumors. However, in this study LNs were pooled and not counted per groin and it remains unclear where the recurrence was located.…”

Section: Discussionmentioning

confidence: 97%

“…To prevent recurrent disease guidelines recommend that a minimum of six LNs should be removed on each side [1,9]. However, limited data on the extent of IFL in regards to clinical outcome is available and the prognostic impact of the amount of resected LNs remains unclear [10][11][12][13]. In this study we set out to correlate the number of resected lymph nodes with groin, local and distant recurrence rates to assess the optimal nodal count for adequate treatment of the inguinal area.…”

Section: Introductionmentioning

confidence: 99%

The number of removed lymph nodes by inguinofemoral lymphadenectomy: impact on recurrence rates in patients with vulva carcinoma

Diehl

Volland

Kirn

et al. 2015

Arch Gynecol Obstet

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Does the count after inguinofemoral lymphadenectomy in vulvar cancer correlate with outcome?

Cited by 21 publications

References 30 publications

The Impact of Tumor and Lymph Node Characteristics on Disease Free Survival in Squamous Cell Vulvar Cancer.

The Impact of Tumor and Lymph Node Characteristics on Disease Free Survival in Squamous Cell Vulvar Cancer.

Study of Biomolecular and Clinical Prognostic Factors in Patients With Cancer of the Vulva Undergoing Surgical Treatment

The number of removed lymph nodes by inguinofemoral lymphadenectomy: impact on recurrence rates in patients with vulva carcinoma

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