Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis?

Kolber, Witold; Dumnicka, Paulina; Maraj, Małgorzata; Kuśnierz-Cabała, Beata; Ceranowicz, Piotr; Pędziwiatr, Michał; Maziarz, Barbara; Mazur-Laskowska, Małgorzata; Kuźniewski, Marek; Sporek, Mateusz; Walocha, Jerzy

doi:10.3390/ijms19061820

Cited by 20 publications

(22 citation statements)

References 36 publications

(63 reference statements)

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“…Interleukin-6 significantly improves the predictive value for severe acute pancreatitis but is difficult to detect [34]. With the advent of a fully automated assay, IL-6 is currently being used clinically in some hospitals [35]. Therefore, continuing to study valuable markers is necessary.…”

Section: Discussionmentioning

confidence: 99%

Serum D-dimer levels at admission for prediction of outcomes in acute pancreatitis

Wan

Yang

et al. 2019

BMC Gastroenterol

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Background Systemic alterations in coagulation are associated with complications of acute pancreatitis (AP). D-dimer, a fibrin degradation product, was recently described as a marker of pancreatitis outcome. Early prediction is essential for reducing mortality in AP. The present study aims to assess the relationship between elevated serum D-dimer levels and the severity of AP. Methods We performed an observational retrospective study with data from 3451 enrolled patients with AP. Serum D-dimer levels were measured upon admission, after 24 h and during the week after admission by immunoturbidimetry. Univariate and multivariate analyses were used to determine whether elevated D-dimer levels were independently associated with the severity of AP. Results Of the 3451 AP patients, 2478 (71.8%) had serum D-dimer levels measured within 24 h of hospital admission; 1273 of these patients had D-dimer levels ≤2.5 mg/L, and 1205 had D-dimer levels > 2.5 mg/L (934 patients had mild AP (MAP); 1086, moderately severe AP (MSAP); and 458, severe AP (SAP)). Patients with D-dimer levels > 2.5 mg/L ( n = 1205) had higher incidences of SAP (75.5% vs. 24.5%), acute peripancreatic fluid collection (APFC) (53.3% vs. 46.7%), acute necrotic collection (ANC) (72.4% vs. 27.6%), pancreatic necrosis (PN) (65.2% vs. 34.8%), infected pancreatic necrosis (IPN) (77.7% vs. 22.8%), organ failure (OF) (68.5% vs. 31.5%), persistent organ failure (POF) (75.5% vs. 24.5%), ICU requirement (70.2% vs. 29.8%), and mortality (79.2% vs. 20.8%) than did patients with D-dimer levels ≤2.5 mg/L ( n = 1273). The multivariate analysis showed that patients with higher serum D-dimer levels had poorer prognoses that worsened over time. Conclusion The measurement of D-dimer levels at admission may be useful for risk stratification of AP.

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Section: Discussionmentioning

confidence: 99%

Serum D-dimer levels at admission for prediction of outcomes in acute pancreatitis

Wan

Yang

et al. 2019

BMC Gastroenterol

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“…Kolber et al. 30 stated that an elevated serum Ang-2 level was not significant ( P = 0.1) in predicting severity of AP on day 1 of onset but could predict ( P = 0.041) severity of AP on day 2. Dumnicka et al.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis

Lv¹,

Yao²,

Liu

et al. 2021

J Int Med Res

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Objective Our aim was to assess the accuracy of angiopoietin-2 (Ang-2) as a prognostic marker for acute pancreatitis (AP) with organ failure (OF). Methods We undertook a systematic search of the PubMed, Cochrane Library, Embase, Chinese Journals Full-text, Wanfang, China Biology Medicine disc, and Weipu databases to identify eligible cohort studies on the predictive value of Ang-2 for AP with OF. The main outcome measures were sensitivity and specificity. The effects were pooled using a bivariate mixed-effects model. Results Six articles with seven case-control studies (n = 650) were included. Pooled sensitivity, specificity, and positive and negative likelihood ratios with 95% confidence intervals (CI) for AP with OF were 0.93 (95%CI: 0.75–0.99), 0.85 (95%CI: 0.75–0.92), 6.40 (95%CI: 3.36–12.19), and 0.08 (95%CI: 0.02–0.36), respectively. The area under the summary receiver operating characteristic curve was 0.95 (95%CI: 0.92–0.96), and the diagnostic odds ratio was 83.18 (95%CI: 11.50–623.17). Subgroup analysis showed that admission time of AP onset (< or ≥24 hours) was a source of overall heterogeneity. Sensitivity analysis supported this finding. Conclusion Ang-2 had high diagnostic accuracy for AP with OF; the best prediction of Ang-2 may be 24 to 72 hours after onset of AP.

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“…Other inflammatory markers are also associated with AKI in AP. During the first two days of AP, serum urokinase-type plasminogen activator receptor (uPAR) positively predicted AKI [111], while serum interleukin 6 positively correlated with renal markers (cystatin C and NGAL) [112].…”

Section: Other Markers Associated With Kidney Injury In Apmentioning

confidence: 99%

Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

Wajda

Dumnicka

Maraj

et al. 2019

IJMS

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Acute kidney injury (AKI) is a serious complication of acute pancreatitis (AP), which occurs in up to 70% of patients with severe AP and significantly increases the risk of mortality. At present, AKI is diagnosed based on dynamic increase in serum creatinine and decreased urine output; however, there is a need for earlier and more accurate biomarkers. The aim of the study was to review current evidence on the laboratory tests that were studied as the potential biomarkers of AKI in AP. We also briefly summarized the knowledge coming from the studies including sepsis or ICU patients since severe acute pancreatitis is associated with systemic inflammation and organ failure. Serum cystatin C and serum or urine NGAL have been shown to predict or diagnose AKI in AP; however, this evidence come from the single center studies of low number of patients. Other markers, such as urinary kidney injury molecule-1, cell cycle arrest biomarkers (tissue inhibitor metalloproteinase-2 and urine insulin-like growth factor-binding protein 7), interleukin-18, liver-type fatty acid-binding protein, or calprotectin have been studied in other populations suffering from systemic inflammatory states. In AP, the potential markers of AKI may be significantly influenced by either dehydration or inflammation, and the impact of these factors may be difficult to distinguish from kidney injury. The subject of AKI complicating AP is understudied. More studies are needed, for both exploratory (to choose the best markers) and clinical (to evaluate the diagnostic accuracy of the chosen markers in real clinical settings).

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Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis?

Cited by 20 publications

References 36 publications

Serum D-dimer levels at admission for prediction of outcomes in acute pancreatitis

Serum D-dimer levels at admission for prediction of outcomes in acute pancreatitis

Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis

Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis

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