Does the association of blood-derived growth factors to nanostructured carbonated hydroxyapatite contributes to the maxillary sinus floor elevation? A randomized clinical trial

Mourão, Carlos Fernando de Almeida Barros; Lourenço, Emanuelle Stellet; Nascimento, Jhonathan Raphael Barros; Mello-Machado, Rafael Coutinho; Rossi, Alexandre Malta; Leite, Paulo Emílio Corrêa; Granjeiro, José Mauro; Alves, Gutemberg Gomes; Calasans-Maia, Mônica Diuana

doi:10.1007/s00784-018-2445-7

Cited by 19 publications

(25 citation statements)

References 35 publications

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“…The researchers in this study followed a checklist of twenty-two items proposed by the Consolidated Standards of Reporting Trials (CONSORT ® ), aimed at complete and transparent reporting of information to reflect on the quality of the study and enable the practice of ideas advocated by evidence-based practice. The minimum sample size (10 individuals per group) was established in an attempt to minimize publication bias [5,25,26].…”

Section: Methodsmentioning

confidence: 99%

“…Although previous studies have shown the biocompatibility of CHA in pre-clinical [21] and clinical studies [25], the events of bone repair after dental extraction in humans during intervention with CHA microspheres, remain unclear. Based on this background, the purpose of the present study was to compare the effects of bioabsorbable nanostructured carbonated hydroxyapatite (CHA) with a bovine xenograft (Bio-Oss ® ), known to be biocompatible and osteoconductive, and clot (control group) in alveolar preservation.…”

Section: Introductionmentioning

confidence: 99%

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Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

et al. 2019

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The properties of the biodegradation of bone substitutes in the dental socket after extraction is one of the goals of regenerative medicine. This double-blind, randomized, controlled clinical trial aimed to compare the effects of a new bioabsorbable nanostructured carbonated hydroxyapatite (CHA) with a commercially available bovine xenograft (Bio-Oss®) and clot (control group) in alveolar preservation. Thirty participants who required tooth extraction and implant placement were enrolled in this study. After 90 days, a sample of the grafted area was obtained for histological and histomorphometric evaluation and an implant was installed at the site. All surgical procedures were successfully carried out without complications and none of the patients were excluded. The samples revealed a statistically significant increase of new bone formation (NFB) in the CHA group compared with Bio-Oss® after 90 days from surgery (p < 0.05). However, the clot group presented no differences of NFB compared to CHA and Bio-Oss®. The CHA group presented less amount of reminiscent biomaterial compared to Bio-Oss®. Both biomaterials were considered osteoconductors, easy to handle, biocompatible, and suitable for alveolar filling. Nanostructured carbonated hydroxyapatite spheres promoted a higher biodegradation rate and is a promising biomaterial for alveolar socket preservation before implant treatment.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

et al. 2019

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“…In this study, we used carbonated hydroxyapatite synthesized at 37 °C, the same temperature used in a previous study [ 4 , 5 , 32 ]. Patel et al showed that HA synthesized by lower temperature exhibited a more considerable inflammatory cell and fibroblastic proliferation, with a higher concentration of Ca 2+ in the ECM, and a difference between them in physical parameters: porosity and crystal morphology [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxyapatite (HA) is a naturally occurring mineral, a component of bone and teeth, and a synthesized material with wide application in medicine for the healing of bones. Due to its biocompatibility and bioactivity [ 1 , 2 , 3 ] HA has been used in dentistry as a bone substitute for alveolar ridge preservation [ 4 ], sinus lift elevation [ 5 ], and as a drug carrier to prevent and control inflammatory processes, chronic infections, and to enhance the endogenous healing capacity of bone defects, which ultimately result in the significant improvement of bone regeneration [ 6 , 7 , 8 , 9 ]. Although, the main limitation of HA ceramics is their high crystallinity, low adsorption capacity for drugs, and poor in vivo bioabsorbability.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the In Vivo Biocompatibility of Amorphous Calcium Phosphate-Containing Metals

Moerbeck-Filho

Sartoretto

Uzeda

et al. 2020

JFB

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Among the biomaterials based on calcium phosphate, hydroxyapatite has been widely used due to its biocompatibility and osteoconduction. The substitution of the phosphate group by the carbonate group associated with the absence of heat treatment and low synthesis temperature leads to the formation of carbonated hydroxyapatite (CHA). The association of CHA with other metals (strontium, zinc, magnesium, iron, and manganese) produces amorphous calcium phosphate-containing metals (ACPMetals), which can optimize their properties and mimic biological apatite. This study aimed to evaluate the biocompatibility and biodegradation of ACPMetals in mice subcutaneous tissue. The materials were physicochemically characterized with Fourier Transform InfraRed (FTIR), X-Ray Diffraction (XRD), and Atomic Absorption Spectrometry (AAS). Balb-C mice (n = 45) were randomly divided into three groups: carbonated hydroxyapatite, CHA (n = 15), ACPMetals (n = 15), and without implantation of material (SHAM, n = 15). The groups were subdivided into three experimental periods (1, 3, and 9 weeks). The samples were processed histologically for descriptive and semiquantitative evaluation of the biological effect of biomaterials according to ISO 10993-6:2016. The ACPMetals group was partially biodegradable; however, it presented a severe irritating reaction after 1 and 3 weeks and moderately irritating after nine weeks. Future studies with other concentrations and other metals should be carried out to mimic biological apatite.

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“…Calcium phosphate has been widely used as a bone substitute; 7,8 dental-implant coating; 9 and carrier for proteins, 10 growth factors, 11 and drugs [12][13][14] due to its similarity to bone tissue's mineral content and suitable cellattachment capacity. Among the calcium phosphates, hydroxyapatite in particular has been favored given its biocompatibility, safety, predictability, unlimited availability, lower morbidity for the patient, and cost-effectiveness, which offer significant advantages and make it a good choice for dental-implant coatings.…”

Section: Introductionmentioning

confidence: 99%

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

Sartoretto

Calasans-Maia

Resende

et al. 2020

IJN

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Background and Objective The success rates of dental implants in low-density bone have been reported as a challenge, especially for early or immediate loading in the maxilla posterior area. Nanoscale architecture affects the roughness, surface area, surface energy of the implant and can enhance osseointegration. This study aimed to evaluate the implant-surface topography and biomechanical, histomorphometric, and histological bone responses to a new nanostructured hydroxyapatite surface placed in the iliac crest of sheep. Methods Ten female sheep (2–4 years) received 30 implants (n=10/group): HAnano ® coated (Epikut Plus ® , S.I.N. Implant System, Sao Paulo, SP, Brazil), SLActive (BLX ® , Straumann, Basel, Switzerland), and TiUnite (NobelActive ® , Nobel Biocare, Göteborg, Sweden) surfaces. Scanning electron microscopy with energy-dispersive spectroscopy evaluated the implant surface topography, the insertion torque value, and resonance frequency analysis evaluated the primary stability, bone-implant contact, and bone-area fraction occupancy were evaluated after 14 and 28 days after implant placement. Results The surface morphology was considerably comparable between the implant groups’; however, the TiUnite ® group presented a remarkable different surface. The SLActive ® and TiUnite ® groups presented an insertion torque average of 74 (±8.9) N/cm that was similar to that of HAnano ® 72 (±8.3) N/cm (p >0.05). The resonance frequency evaluated with Osstell ® /SmartPeg ® or Penguin ® /MulTipeg ® showed similar results when assessing implants from the same group. BIC and BAFO significantly increased (p<0.05) throughout the experimental periods to all groups, but BIC and BAFO values were similar among the implants at the same time point. After 4 weeks, bone-implant contact was higher than 80% of the total length analyzed. New bone occupies around 60% of analyzed area around the implants. Conclusion HAnano ® coated surface promoted comparable osseointegration as SLActive and TiUnite in the sheep model. The three tested surfaces showed comparable osseointegration at the early stages of low-density bone repair in the sheep model.

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Does the association of blood-derived growth factors to nanostructured carbonated hydroxyapatite contributes to the maxillary sinus floor elevation? A randomized clinical trial

Abstract: Equivalent new bone formation was observed for cHA in the presence or absence of the BDGF concentrate in bilateral sinus floor elevation after 6 months. Blood-derived growth factors did not improve bone repair when associated with calcium phosphate in sinus lift procedures.

Cited by 19 publications

References 35 publications

Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

Randomized Controlled Clinical Trial of Nanostructured Carbonated Hydroxyapatite for Alveolar Bone Repair

Evaluation of the In Vivo Biocompatibility of Amorphous Calcium Phosphate-Containing Metals

<p>The Influence of Nanostructured Hydroxyapatite Surface in the Early Stages of Osseointegration: A Multiparameter Animal Study in Low-Density Bone</p>

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