Abstract:Background. In many resource-limited countries, children are routinely given intramuscular (IM) injections of medication to treat pain or illness. IM injections are suspected in the development of gluteal fibrosis (GF) in children, a condition that limits normal hip motion and function. The mechanism by which GF develops is not understood. Our study examines a commonly IM administered antimalarial in Uganda, quinine, to assess its ability to cause fibrogenesis of muscle fibro/adipogenic progenitors (FAPs), the… Show more
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