Does the Aging Process Significantly Modify the Mean Heart Rate?

Santos, Marcos César de Oliveira; Sousa, Antônio Carlos Sobral; Reis, Francisco Prado; Santos, Thayná Ramos; Lima, Sônia Oliveira; Barreto‐Filho, José Augusto

doi:10.5935/abc.20130188

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…Resting heart rate declined with age in the present study, as is consistent with cross-sectional [22,23] and longitudinal [24] data. The findings of these studies suggest that the decreased adrenergic response with aging is an important mechanism related to lower resting pulse rate and its protective effect [22][23][24].…”

Section: Time Trends In Ecg Findings Of Subjectssupporting

confidence: 92%

Trends in coronary risk factors and electrocardiogram findings from 1977 to 2009 with 10-year mortality in Japanese elderly males – The Tanushimaru Study

Nakamura

Adachi

Enomoto

et al. 2017

Journal of Cardiology

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Section: Time Trends In Ecg Findings Of Subjectssupporting

confidence: 92%

Trends in coronary risk factors and electrocardiogram findings from 1977 to 2009 with 10-year mortality in Japanese elderly males – The Tanushimaru Study

Nakamura

Adachi

Enomoto

et al. 2017

Journal of Cardiology

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“…Arrhythmia is a common occurrence of aging [ 20 , 21 ]. Bradycardia has been reported in younger patients and may not require immediate intervention if symptomatically mild [ 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

Zhou

Wang

et al. 2016

Genes Nutr

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BackgroundEnvironmental factors are well-known causes of diseases. However, aside from a handful of risk indicators, genes’ encoding susceptibility to chronic illnesses and their associated environmental triggers are largely unknown. In this era of increasingly rich diets, such genetic predispositions would be immensely helpful from a public health perspective. The novel transgenic mouse model with liver-specific NG37 overexpression characterized in this article identifies the diet-dependent function of NG37 in the pathogenesis of fatty liver disease and cardiac arrhythmia.ResultsThe liver-specific NG37 overexpression transgenic mouse model described here was generated using the Alb-SV40 polyA expression plasmid backbone. NG37 cDNA under control of the albumin promoter for liver-specific expression was fused with a 5′ terminal M2 FLAG sequence and a SV40 early region transcription terminator/polyadenylation site attached at the 3′-UTR. These NG37 transgenic mice developed normally and were physiologically normal on a standard diet. However, in comparison to non-transgenic (nTG) litter mates, these mice develop dramatic phenotypes within 12–18 days of starting a high-fat diet: (i) increased body weight (28.5 ± 12.3 g), (ii) increased liver weight (87.4 ± 35.7 mg), (iii) increased heart weight (140 ± 38.4 mg), and (iv) cardiac arrhythmia. The enlarged livers of high-fat diet NG37 transgenic mice was histologically similar to human fatty liver disease and contained Maltese cross birefringent active depositions in hepatocytes that are indicative of fatty liver disease. We also confirmed via X-ray diffraction the steatotic vesicles in the diseased hepatocytes of our high-fat diet NG37 mice was composed of cholesteryl derivatives also found in human fatty liver disease. In addition to cardiac enlargement, NG37 transgenic mice on high-fat diet also exhibited highly irregular bradycardia not present in either high-fat diet nTG littermates or normal-diet transgenic litter mates.ConclusionsThe dramatic high-fat diet-dependent symptoms (increased body weight, cardiac enlargement, fatty liver, and cardiac arrhythmias) characterized in our liver-specific NG37 overexpression mouse model identifies NG37 as a gene encoding latent lipid metabolism pathology induced only in the presence of an environmental factor relevant to human health: high-fat diet.

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“…In [ 49 ], for instance, it is reported how young adults and older adults present differences in emotional reactivity when positive or negative emotions are elicited by movies. The authors of [ 50 , 51 ] reported that the average heart rate of a subject as well as his/her heart rate variability tends to decrease with age. In [ 52 ], it is shown how the gait pattern of a subject during different cognitive load tasks tends to become less regular with the increase in the subject’s age.…”

Section: State Of the Artmentioning

confidence: 99%

Behavior and Task Classification Using Wearable Sensor Data: A Study across Different Ages

Gasparini

Grossi

Giltri

et al. 2023

Sensors

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In this paper, we face the problem of task classification starting from physiological signals acquired using wearable sensors with experiments in a controlled environment, designed to consider two different age populations: young adults and older adults. Two different scenarios are considered. In the first one, subjects are involved in different cognitive load tasks, while in the second one, space varying conditions are considered, and subjects interact with the environment, changing the walking conditions and avoiding collision with obstacles. Here, we demonstrate that it is possible not only to define classifiers that rely on physiological signals to predict tasks that imply different cognitive loads, but it is also possible to classify both the population group age and the performed task. The whole workflow of data collection and analysis, starting from the experimental protocol, data acquisition, signal denoising, normalization with respect to subject variability, feature extraction and classification is described here. The dataset collected with the experiments together with the codes to extract the features of the physiological signals are made available for the research community.

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Does the Aging Process Significantly Modify the Mean Heart Rate?

Cited by 8 publications

References 25 publications

Trends in coronary risk factors and electrocardiogram findings from 1977 to 2009 with 10-year mortality in Japanese elderly males – The Tanushimaru Study

Trends in coronary risk factors and electrocardiogram findings from 1977 to 2009 with 10-year mortality in Japanese elderly males – The Tanushimaru Study

Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

Behavior and Task Classification Using Wearable Sensor Data: A Study across Different Ages

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