Does the Age of Pharmaceuticals Matter? Undetectable Hydrate Seeds Impact Hydration Behavior

Abstract

A study on the hydration behavior of fluconazole demonstrates that both sample age and polymorphic form impact the drug’s kinetic stability to hydration. For two of the polymorphs, aged samples were found to hydrate more readily than fresh samples. The aging effect was attributed to the formation of monohydrate (MH) crystals over time. The MH, despite being initially undetectable, had a seeding effect, thus impacting the hydration kinetics.

Professor Roger Davey: Master ofAllCrystal Trades

“…More than 20 crystallization scientists trained by Roger have gone on to work in the pharmaceutical industry for at least six different companies. This virtual special issue in Celebration of the Career of Roger Davey contains papers that deal with pharmaceutical materials − or arise from the collaboration between academia and the pharmaceutical industry − or come directly from the pharmaceutical industry. , …”