Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss?

Chi, Tzu-Hang; Chiang, Ming-Chou; Chen, R F; Yuan, Chien Han

doi:10.1136/jramc-2017-000872

Cited by 8 publications

(7 citation statements)

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“…Ten suitable trials involving 1295 patients were retrieved (Table 3 ) [ 17 – 25 ]. A study conducted by Topuz et al, demonstrated an average of the hearing gain at five contiguous frequencies significantly higher in the HBO + SS group for patients with severe or profound hearing impairment (respectively, p = 0.014 and p = 0.005) [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

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The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Eryigit

Ziylan

Yaz

et al. 2018

Eur Arch Otorhinolaryngol

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ObjectiveTo evaluate the effectiveness of hyperbaric oxygen in the treatment of patients with idiopathic sudden sensorineural hearing loss (ISSHL).Data sourcesAn Embase, MEDLINE and Cochrane search were utilised to identify various clinical trials on the treatment of ISSHL. Studies that were published between 2002 and 2018 and written in the English, Dutch or German language were included. Search terms included synonyms for idiopathic sudden hearing loss.Data synthesisA total of 16 articles were identified regarding hyperbaric oxygen therapy. All patients were evaluated with pure-tone audiometry. A major part of the cases presented with unilateral hearing loss(bilateral hearing loss less than 5%). In several studies, the average of the mean hearing gain at five contiguous frequencies was significantly higher in the hyperbaric oxygen (HBO) therapy and systemic steroid (SS) group in patients with severe or profound hearing impairment. They recorded a significant treatment effect (p = 0.005) of HBO + SS therapy on patients with an initial hearing loss of ≥ 81 dB.ConclusionsOn the whole group of ISSHL patients, no significant difference was demonstrated between the intervention and control group. However, in severe or profound hearing-impaired ISSHL patients, significant benefit was observed in the intervention group. These results likely indicate that adding HBO to steroid therapies might be of benefit in cases of severe and profound hearing impairment.

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Section: Resultsmentioning

confidence: 99%

“…However, this difference was not significant ( p = 0.754) [ 22 ]. In three studies, a significant improvement was found after the addition of HBO therapy [ 23 – 25 ].…”

Section: Resultsmentioning

confidence: 99%

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Eryigit

Ziylan

Yaz

et al. 2018

Eur Arch Otorhinolaryngol

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“…Previous research into HBOT for SSNHL included 12 randomized controlled trials (RCTs), 5 , 6 , 15 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 and three meta‐analyses. 8 , 9 , 10 A significant trial by Krajcovicova et al 5 reported an 11.5 dB improvement in hearing when HBOT supplemented pharmacotherapy as a first‐line treatment for SSNHL.…”

Section: Discussionmentioning

confidence: 99%

Clinical impact of hyperbaric oxygen therapy combined with steroid treatment for sudden sensorineural hearing loss: A case–control study

Sanda,

Sawabe,

Kabaya

et al. 2024

Laryngoscope Investig Oto

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ObjectivesThe aim of present study was to evaluate the clinical efficacy of hyperbaric oxygen therapy (HBOT) as a primary therapy combined with standard systemic corticosteroid treatment for sudden sensorineural hearing loss (SSNHL) compared to treatment without the use of HBOT (non‐HBOT) through clinical data and advanced analytical approaches.Study DesignCase–control study.MethodsConducted across three Japanese medical centers involving 298 SSNHL patients diagnosed between 2020 and 2023. Inclusion criteria encompassed first onset and treatment, WHO grade 3 or 4 initial hearing impairment, receipt of systemic corticosteroid therapy within 14 days of symptom onset, and initiation of HBOT within the same timeframe for the case group. The primary outcome measure was the difference in hearing improvement (mean hearing level in decibels, dB) between the two groups, assessed by pure‐tone audiometry at baseline and 3 months post‐treatment, using the inverse probability of treatment weighting (IPTW) method adjusted for covariate differences.ResultsThe study included 67 patients in the HBOT group and 68 in the non‐HBOT group. The HBOT group exhibited significantly greater hearing improvement (IPTW‐adjusted difference: 7.6 dB, 95% CI 0.4–14.7; p = 0.038). Patients without vertigo in the HBOT group demonstrated substantial hearing improvement (11.5 dB, 95% CI 2.3–20.6; p = 0.014), whereas those with vertigo showed no significant improvement (−1.8 dB, 95% CI −11.8–8.3; p = 0.729). The HBOT group also had a significantly higher association with complete recovery (IPTW‐adjusted odds ratio: 2.57, 95% CI 1.13–5.85; p = 0.025).ConclusionIn SSHNL, HBOT combination therapy yielded slightly but significantly improved hearing outcomes compared to non‐HBOT treatment.Level of Evidence4.

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“…In both groups, therapy was initiated early, on average within 4 days. Complete hearing recovery was significantly better in the HBOT group after 180 days (27% vs 10%, P = 0.043) [ 121 ].…”

Section: Clinical Use Of Hyperbaric Oxygen Therapymentioning

confidence: 99%

“…Examples of treatments are blood flow-promoting agents, vasodilators, diuretics, dextran and pentoxifylline. However, many of those studies (Chi, Liu, Ohno, Satar, Narozny, Aslan, Topuz, Racic) have failed to show effectiveness in the clinical setting [ 81 – 84 , 91 , 104 , 105 , 121 ].…”

Section: Clinical Use Of Hyperbaric Oxygen Therapymentioning

confidence: 99%

The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review

Bayoumy

2019

Eur Arch Otorhinolaryngol

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Introduction Acute hearing loss can have a major impact on a patient’s life. This holds true for both acute acoustic trauma (AAT) and idiopathic sudden sensorineural hearing loss (ISSHL), two devastating conditions for which no highly effective treatment options exist. This narrative review provides the rationale and evidence for HBOT in AAT and ISSHL. Methods Narrative review of all the literature available on HBOT in acute hearing loss, studies were retrieved from systematic searches on PubMed and by cross referencing. Discussion First, the etiological mechanisms of acute hearing loss and the mechanism of action of HBOT were discussed. Furthermore, we have provided an overview of 68 studies that clinically investigated the effect of HBOT in the last couple of decades. For future studies, it is recommend to start as early as possible with therapy, preferably within 48 h and to use combination therapy consisting of HBOT and corticosteroids. Implications for practice HBOT has been used quite extensively for acute hearing loss in the last couple of decades. Based on the amount of studies showing a positive effect, HBOT should be discussed with patients (shared decision making) as optional therapy in case of AAT and ISSHL.

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Does the addition of hyperbaric oxygen therapy to conventional treatment modalities influence the outcome of soldiers with idiopathic sudden sensorineural hearing loss?

Abstract: HBOT plus existing conventional treatment was associated with a better outcome than conventional treatment alone. We would recommend the addition of HBOT is recommended as a first-line treatment modality for all soldiers presenting with ISSNHL.

Cited by 8 publications

References 5 publications

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

The effectiveness of hyperbaric oxygen in patients with idiopathic sudden sensorineural hearing loss: a systematic review

Clinical impact of hyperbaric oxygen therapy combined with steroid treatment for sudden sensorineural hearing loss: A case–control study

The use of hyperbaric oxygen therapy in acute hearing loss: a narrative review

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