Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?

Gaston, Czar Louie; Bhumbra, Rej; Watanuki, Munenori; Abudu, A.; Carter, S. R.; Jeys, Lee; Tillman, R. M.; Grimer, R. J.

doi:10.1302/0301-620x.93b12.27663

Cited by 98 publications

(102 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several local adjuvants of inactivation methods in the lesion site have been reported to decrease GCT recurrence, specifically high‐speed burring, phenol, cementing, electrocoagulation, and cryotherapy26, 27, 28.…”

Section: Discussionmentioning

confidence: 99%

“…Then the surgical site was soaked with hydrogen peroxide. Meanwhile packing the bone defect with cement could also inactivate the lesion site with its thermal and toxic effect27, 28, and it is easy to find tumor recurrence on the edge. Without doubt, high‐speed burring has a good effect in terms of inactivating the lesion site, which we usually use in extremities29.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases

Lin

Teng

et al. 2018

Orthopaedic Surgery

View full text Add to dashboard Cite

ObjectiveTo review the clinical details and further treatments for recurrent spinal giant cell tumors (SGCT), and to analyze the risk factors of recurrence and shed new light on the treatment options and prognosis of recurrent SGCT.MethodsA retrospective analysis of recurrent SGCT between April 2003 and January 2014 was performed. A total of 10 patients comprising 3 men and 7 women with a mean age of 28.9 years (range, 21–40 years) were included in the study. All complete clinical data, radiographs, CT, MRI, scans and pathological data were reviewed. The tumor locations and the regions involved were evaluated by CT and MRI. The blood supply of the tumors was evaluated by enhanced CT and MRI. The mean follow‐up was 81.3 months (range, 35.7–172.1 months).ResultsAll patients had Enneking stage 3 tumors; 9 (90%) of them had different extents of spinal canal involvement in the primary time period. All patients underwent intralesional resection during their first surgery. Only 1 patient received local adjuvant treatments; no patient underwent selective arterial embolization or used denosumab at that time. Only 1 patient underwent adjuvant radiotherapy postoperatively, and another patient used bisphosphonates. After recurrence, 1 patient was cured using denosumab, and 2 patients' disease was controlled through use of other medical treatments or adjuvant treatments. There were 3 repeated recurrences and 7 repeated surgical procedures were performed in 5 patients. There were 6 intralesional excisions and 1 decompression surgery. The mean relapse‐free time after the first surgery was 32.3 months (range, 10.5–62.6 months). The overall mean relapse‐free time was 40.2 months (range, 10.5–157 months). No distant metastasis was found in our series. At the final follow‐up, 4 patients were disease free, 3 patients' disease was under control, 2 has progressive disease aggravation, while 1 patient died as a result of progression of disease 133.9 months after first surgery.ConclusionIntralesional excision for recurrent spinal giant cell tumors is an effective option that may have satisfactory prognosis. However, the excision and the inactivation of the lesion should be carried out carefully and thoroughly without missing any corners. Early diagnosis of recurrence may be associated with better prognosis. Adjuvant treatments perioperatively and systemic medical treatments can decrease recurrence rates and can have therapeutic effects in the recurrent SGCT.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases

Lin

Teng

et al. 2018

Orthopaedic Surgery

View full text Add to dashboard Cite

show abstract

“…Denosumab tedavisinden sonra gelişen septaların duvarında canlı hücreler kalabilir tümör hücreleri yeni oluşan kemikte kaldığından dolayı küretajın cerrahi tekniği, daha yüksek lokal nüks oranları önlemek için daha agresif olarak uygulanmalıdır (37). Yeniden kemikleşmiş bölgelerde kalan tümöre ulaşmak için ve lokal kontrolün artırılması için intraoperatif yüksek hızlı burr kriyoterapi ,fenol, sıvı azot kullanımı önerilmektedir (9,16,55,56).…”

Section: Denosumab Tedavisi Sonrası Dev Hücreli Tümörde Tekrarlamaunclassified

“…Küretaj ile tedavi edilen Campanacci 3 lezyon, Campanacci 1 veya 2 lezyonlara kıyasla daha yüksek lokal nüks oranları ile ilişkilidir (8,9). Lokal rekürrens oranı vakaların % 19-50'sinde olduğu ve genellikle 2 yılda ortaya çıktığı bildirilmektedir (10)(11)(12).…”

Section: Introductionunclassified

See 1 more Smart Citation

Denosumab Therapy in Giant Cell Bone Tumor: Review of Literature

Balta¹,

Kurnaz²,

Aytekin³

et al. 2017

Acta Oncol Tur.

View full text Add to dashboard Cite

ÖZETDenosumab kemik dev hücreli tümörünü yönetmek için etkili ve kullanışlı bir ilaçtır. İnoperable veya metastatik dev hücreli tümörlü hastalar için birinci basamak tedavide altın standart olarak düşünülmektedir. Dev hücreli kemik tümöründe denosumabınetkinliği prospektifrandomize çalışmalarda kanıtlanmıştır. Nörovasküler yapılara yakın büyük dev hücreli tümörde daha fazla morbiditeye yol açaçak rezeksiyona yönelmek yerine denosumab ile neoadjuvan tedavi dev hücreli tümörde intralezyonel cerrahiyi kolaylaştırabilir. Farklı sebeplerden dolayı tedaviyi bıraktıktan sonra yapılan biyopside psödosarkomatöz değişiklikler görülebileceği unutulmamalıdır. Dev hücreli tümörde denosumab tedavisi sonrası kalınlaşmış korteks ve subkondral kemik içerisinde tümör hücrelerinin gizlenmesi sonucu lokal tümör rekürrensi görülebilir. Denosumab çenede osteonekroz oluşumu ile ilişkilendirilmiştir. Bu makalede denosumab tedavisi alan hastaların sistematik değerlendirilmesi,risk faktörleri, tanı-tedavi yararlığı, tedavi seçeneklerini öngören kılavuzlar sunulmuştur. Anahtar Kelimeler: denosumab, dev hücreli tümörü, cerrahi ABSTRACT Denosumab is an effective and usefull drug for managing the giant cell bonetumor. It is considered the gold standard for treatment of the inoperable or metastatic giant cell tumors. Theefficacy of denosumab in giant cell bone tumors has been demonstrated in prospective randomized trials. Neoadjuvant therapy with denosumab may facilitate intralesional surgery in giant cell tumor instead of resection leading to more morbidity in a large giant cell tumor close to the neurovascular structure. It should not be forgotten that pseudosarcomatous changes in biopsies may ocur after denosumab treatment due to different reasons. Giant cell tumor may result in dense cortex after denosumab treatment and local tumor recurrence after concealment of tumor cells within the subchondral bone. Denosumab is associated with jaw osteonecrosis formation. In this article, guidelines for systematic evaluation, risk factors, diagnostic-therapeutic usefullness and treatment options for patients treated with denosumab are presented. Keywords: denosumab, giant cell bone tumor, surgery GirişDev hücreli kemik tümörü benign fakat lokal olarak agresif davranış gösteren ve genellikle genç erişkinleri etkileyen bir lezyondur (1). Dev hücreli kemik tümöründen etkilenen hastaların % 1-4 ünde çoğu benign olmak üzere akciğer metastazı görülür (2, 3). Dev hücreli kemik tümörleri tüm primer kemik tümörlerinin % 4-5'ini ve tüm benign tümörlerin % 20'sini oluşturur. Kadınlarda 1,5-2 kat daha fazla görülür ve genellikle genç kadınları (20-40 yaş arası) etkiler (1, 4). Dev hücreli kemik tümörünün distal femur, proksimal tibia, distal radius ve proksimal humerus en sık rastlanan tutulum yeridir (5). Aksiyel iskelette en fazla sakrumda görülür (1,4,5). Kemiğin korteksini genellikle inceltir, çoğunlukla ekspanse olur. Yumuşak doku genişlemesi ile veya yumuşak doku genişlemesi olmadan kortekste lizis yapabilir (6). Anterior vertebral kolon tutulumu sıklıkla ...

show abstract

Denosumab in Giant Cell Tumors of Bone

Parry

Grimer

2021

Evidence‐Based Orthopedics

View full text Add to dashboard Cite

Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?

Cited by 98 publications

References 25 publications

Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases

Recurrence of Giant Cell Tumor of the Spine after Resection: A Report of 10 Cases

Denosumab Therapy in Giant Cell Bone Tumor: Review of Literature

Denosumab in Giant Cell Tumors of Bone

Contact Info

Product

Resources

About