Does the absence or presence of seminal fluid matter in patients undergoing ovulation induction with intrauterine insemination?

Qasim, Suna M.; Trias, Alexis; Karacan, Meriç; Shelden, Robert M.; Kemmann, Ekkehard

doi:10.1093/oxfordjournals.humrep.a019285

Cited by 8 publications

(6 citation statements)

References 6 publications

(6 reference statements)

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“…Embryo implantation rates were not different in a third study in couple who had coitus at least once 12 hr after embryo transfer 51 . A study in which seminal fluid was placed intravaginally at the time of intrauterine insemination (IUI) with spermatozoa washed out of semen revealed no difference in pregnancy rate when compared with a saline control 52 . Unfortunately, all of these studies were of small size and did not define their clinical populations well.…”

Section: Why Don’t Women Develop An Immunity To Sperm?mentioning

confidence: 99%

Biology of the Male Reproductive Tract: Its Cellular and Morphological Considerations

Bronson

2010

American J Rep Immunol

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Citation  Bronson R. Biology of the male reproductive tract: Its cellular and morphological considerations. Am J Reprod Immunol 2011; 65: 212–219 For many years, the focus of attention in the study of semen has been on spermatozoa, its major cellular component, given their importance in the process of reproduction, and the role of the seminal fluid as their transport medium. More recently, evidence has accumulated of the complexity of seminal fluid, its components that perturb the female reproductive tract in ways promoting both survival of spermatozoa there‐in and facilitating the implantation of embryos within the endometrium, hence initiating pregnancy. These same factors, however, may also make the female reproductive tract susceptible to invasion not only by spermatozoa but viruses, playing a significant role in the male‐to‐female transmission of HIV. Knowledge of the histology, anatomy, and immunology of the male reproductive tract is essential in understanding its role in HIV pathogenesis.

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Section: Why Don’t Women Develop An Immunity To Sperm?mentioning

confidence: 99%

Biology of the Male Reproductive Tract: Its Cellular and Morphological Considerations

Bronson

2010

American J Rep Immunol

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“…Qasim found that application of SP in vagina during intrauterine insemination does not improve the pregnancy rate [15]. Fishel found no difference in the pregnancy and miscarriage rates between 2 groups with or without SP (32 % versus 33 % and 21 % versus 17 %) [6].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have investigated the role of SP in implantation with controversial results, some reporting benefits [1,19,21], whereas others showing no effect [6,15].…”

Section: Introductionmentioning

confidence: 99%

Seminal plasma insemination during ovum-pickup—a method to increase pregnancy rate in IVF/ICSI procedure. A pilot randomized trial

Chicea¹,

Ispasoiu²,

Focşa

2013

J Assist Reprod Genet

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Purpose In IVF procedures, endometrial function is a limiting factor of the pregnancy rate and the aims of this study is to determine whether seminal plasma insemination at ovum pick-up in IVF has any effect on pregnancy rate. Methods We designed a single center, 2 parallel groups, randomized pilot study. All couples undergoing an IVF procedure in our clinic between January 2010 and December 2011 were considered for enrollment in the study. The patients who met the inclusion criteria were randomized into two groups by simple randomization: the seminal plasma group (SP group) and the reference group (noSP group). We applied seminal plasma into the cervix and vaginal vault at the time of the OPU in the patients of the SP group. The primary outcome was the clinical pregnancy rate in the SP group compared with the noSP group and the secondary outcome measure was the implantation rate. Results 400 patients met the inclusion criteria and were randomized. 54 patients were excluded from the study mainly because they didn't undergo the embryo transfer. Finally, 164 patients were included in the SP group and 182 patients in the noSP group and analyzed. We found a statistically non-significant increase in the pregnancy rate in the SP group (55.5 % versus 44 %, p=0.09) and a statistically significant increase in the implantation rate (34.7 % versus 27.5 %, p=0.026). Conclusions Our results support the idea that SP insemination may have the potential to increase pregnancy rate in IVF procedures but further studies must be carried out.

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“…A comparison of clinical pregnancy rates between two groups showed no significant difference. Further in non-participants with unregulated intercourse, the pregnancy rates were not significantly different (25). Coulam and Stern suggested that higher implantation rates were obtained in a group of women experiencing infertility and/or recurrent spontaneous abortion who received vaginal capsules of seminal plasma versus placebo, however this difference was not significant (26).…”

Section: Clinical Studiesmentioning

confidence: 99%

Intercourse and ART Success Rates

Aflatoonian¹,

Ghandi²,

Tabibnejad³

2012

Advances in Embryo Transfer

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Does the absence or presence of seminal fluid matter in patients undergoing ovulation induction with intrauterine insemination?

Cited by 8 publications

References 6 publications

Biology of the Male Reproductive Tract: Its Cellular and Morphological Considerations

Biology of the Male Reproductive Tract: Its Cellular and Morphological Considerations

Seminal plasma insemination during ovum-pickup—a method to increase pregnancy rate in IVF/ICSI procedure. A pilot randomized trial

Intercourse and ART Success Rates

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