C occidioidomycosis (Valley fever or San Joaquin Valley fever) is a pulmonary and systemic infection that results from respiratory exposure to aerosolized arthroconidia spores of soil-dwelling species of Coccidioides fungi (1). Coccidioides fungi and coccidioidomycosis are strongly associated with the semiarid climate of the Lower Sonoran life zone of the southwestern United States and parts of Mexico, Central America, and South America. Most US cases occur in Arizona and California. However, the fungus and locally acquired cases have recently been reported as far north as Washington state, potentially related to changes in climate and land use patterns (2,3). In California, the species most often implicated in human infection is C. immitis, whereas in Arizona it is C. posadasii (2,3). After an incubation period of ≈1-3 weeks, most infected persons experience few or mild symptoms, and the condition usually resolves within weeks or months, often unrecognized (4,5). Approximately 40% of infected persons experience an influenza-like illness with cough, fever, and fatigue that typically resolves without treatment. Approximately 1% of cases involve dissemination to skin, bone, meninges, and other tissues (6); patients with disseminated disease require long-term antifungal therapy and may die (7). Risk factors for disseminated disease include male sex, age >60 years, pregnancy, immunocompromise, and African and Filipino ancestry (8). Case identification is based on clinically compatible illness with confirmatory laboratory evidence or skin-test conversion (9). Local health departments may find it impractical to obtain clinical information and thus may identify cases solely on the basis of laboratory results (4). Because most cases are subclinical, public health surveillance substantially underestimates infection risk. McCotter et al. estimated that the true number of cases is ≈4-6-fold greater than that captured by public health surveillance (2). Residence in or visits to coccidioidomycosis-endemic areas may lead to exposure and infection. The largest outbreaks have been associated with natural phenomena. A December 1977 dust storm in California's San Joaquin Valley (an area of high coccidioidomycosis endemicity, from which the disease derives its common name) resulted in a ≥10-fold increase in incidence in 15 of the state's 58 counties (1,10). The 1994 Northridge, California, earthquake was responsible for 203 outbreak-associated cases, including 3 deaths (11). Occupational risk has been associated with soil-disruptive activity involving archeologists (12), film crews (13), solar power farm construction workers (14,15), roadway and construction workers