Does TCF7L2 polymorphisms increase the risk of gestational diabetes mellitus in South Indian population?

Nicolaï, Thomas; Mahesh, D M; Chapla, Aaron; Paul, Johan; Shwetha, N; Christina, Flory; Asha, Hesarghatta Shyamasunder

doi:10.1530/endoabs.34.p270

Cited by 7 publications

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“…One hundred and seventy-one articles were initially identified through literature search. These included 28 from PubMed, 50 from Web of Science, 46 from EMBASE (Ovid SP), 5 from Airiti Library, 26 from Medline Complete, 14 from ProQuest, and one article identified through google website search [ 40 ] and another article identified through reference list of a meta-analysis [ 41 ]. Same articles (n = 94) identified from different databases were initially excluded.…”

Section: Resultsmentioning

confidence: 99%

“…Subsequently, additional 61 articles were excluded for the following reasons: (1) one article on non-human model of GDM [ 42 ]; (2) two meta-analyses on association between TCF7L2 polymorphism and GDM; (3) 13 non case-control studies; (4) 34 studies unrelated to TCF7L2 gene and GDM; (5) five studies not focus on rs7903146 polymorphism; (6) four articles lacking genotype frequency data in the text or from corresponding authors [ 43 – 46 ]; (7) two abstracts [ 47 – 48 ] sharing -in part- the same participants with other articles [ 46 , 49 ]. Hence, 16 studies published between 2007 and 2015 were ultimately retained in this meta-analysis [ 9 , 10 , 26 – 29 , 31 , 32 , 40 , 41 , 49 – 54 ] ( S1 Text ).…”

Section: Resultsmentioning

confidence: 99%

“…However, studies to determine the relationship between TCF7L2 rs7903146 polymorphism and risk of GDM in Hispanics/Latinos were not available until recently [ 29 , 31 , 32 ]. In our meta-analysis, we were not only able to incorporate these recent Hispanics/Latinos studies but also one study from China [ 53 ] and another from India [ 40 ] to perform analyses in racial/ethnic subgroups.…”

Section: Discussionmentioning

confidence: 99%

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Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis

Lin

Yeh

et al. 2016

PLoS ONE

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BackgroundThere are racial and ethnic differences in the prevalence of gestational diabetes mellitus (GDM). Prior meta-analyses included small samples and very limited non-Caucasian populations. Studies to determine the relationship between transcription factor 7 like-2 (TCF7L2) rs7903146 polymorphism and risk of GDM in Hispanics/Latinos are recently available. The present meta-analysis was to estimate the impact of allele variants of TCF7L2 rs7903146 polymorphism on GDM susceptibility in overall population and racial/ethnic subgroups.MethodsLiterature was searched in multiple databases including PubMed, Web of Science, EMBASE (Ovid SP), Airiti Library, Medline Complete, and ProQuest up to July 2015. Allelic frequency for TCF7L2 rs7903146 polymorphism in GDM and control subjects was extracted and statistical analysis was performed using Comprehensive Meta-Analysis (CMA) 2.0 statistical software. The association between TCF7L2 rs7903146 polymorphism and GDM risk was assessed by pooled odd ratios (ORs) using five gene models (dominant, recessive, homozygote, heterozygote, and allele). Stratified analysis based on race/ethnicity was also conducted. The between-study heterogeneity and contribution of each single study to the final result was tested by Cochran Q test and sensitivity analyses, respectively. Publication bias was evaluated using Egger’s linear regression test.ResultsA total of 16 studies involving 4,853 cases and 10,631 controls were included in this meta-analysis. Significant association between the T-allele of rs7903146 and GDM risk was observed under all genetic models, dominant model (OR = 1.44, 95% CI = 1.19–1.74), recessive model (OR = 1.35, 95% CI = 1.08–1.70), heterozygous model (OR = 1.31, 95% CI = 1.12–1.53), homozygous model (OR = 1.67, 95% CI = 1.31–2.12), and allele model (OR = 1.31, 95% CI = 1.12–1.53). Stratified analysis by race/ethnicity showed a statistically significant association between rs7903146 polymorphism and susceptibility to GDM under homozygous genetic model (TT versus CC) among whites, Hispanics/Latinos and Asians. Sensitivity analysis showed that the overall findings were robust to potentially influential decisions of the 16 studies included. No significant evidence for publication bias was observed in this meta-analysis for overall studies and subgroup studies.ConclusionsThis meta-analysis showed that the T allele of TCF7L2 rs7903146 polymorphism was associated with susceptibility of GDM in overall population in white, Hispanic/Latino and Asian sub-groups. Asians with homozygous TT allele of rs7903146 polymorphism have highest risk of GDM (OR = 2.08) followed by Hispanics/Latinos (OR = 1.80) and whites (OR = 1.51). The highest and lowest frequency of T allele of rs7903146 was found in Malaysia and South Korea, respectively. Future studies are needed to profile genetic risk for GDM among high risk Asian and Pacific Islander subgroups.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis

Lin

Yeh

et al. 2016

PLoS ONE

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“…The 22 eligible studies captured eight TCF7L2 SNPs, and included 5,573 cases and 13,266 controls. There were 18 studies about rs7903146, 10 about rs12255372, 5 about rs7901695, 3 about rs290487, 2 about rs11196205, 2 17 Asian Korea 32/64.7 Allelic discrimination assay IWCGDM de Melo, (2015) 26 Hispanic/Latino Brazil 32/24 SNP Genotyping Assay ADA Freathy, (2010) 12 Mixed Australia and UK NA Illumina Golden Gate platform OGTT Kan, (2014) 15 Asian China 30.7/30.9 Allelic discrimination assay OGTT Huerta-Chagoya, (2015) 25 20 Caucasian Sweden NA TaqMan allelic discrimination assay OGTT Reyes-L opez, (2014) 21 Mexican Mexico 29/31 PCR ADA RIZK, (2011) 16 Caucasian Qatar NA TaqMan allelic discrimination assay NA Shaat, (2007) 14 Caucasian Scandinavia 32.3/30.5 TaqMan allelic discrimination assay OGTT Shi, (2014) 28 Asian China 30/29 AS-PCR OGTT Stuebe, (2014) 31 African-American USA 24.1 (total) Sequenom iPLEX platform OGTT Thomas, (2014) 24 Asian India NA NA NA Vcelak, (2012) 18 Caucasian Czech Republic 32.8/29.9 TaqMan allelic discrimination assay WHO Wang, (2013) 39 Asian China NA PCR-LDR OGTT Watanabe, (2007) 30 Mexican-American USA 35.0/33.4 TaqMan allelic discrimination assay OGTT Zhang, (2015) 23 Asian Tables 1 and 2.…”

Section: Description Of the Included Studiesmentioning

confidence: 99%

“…So far, TCF7L2 has multiple single nucleotide polymorphisms (SNPs), eight of which have been reported, including rs7903146 [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] ; rs12255372 [16][17][18][19][20][21]26,[28][29][30] ; rs7901695 18,20,25,29,31 ; rs290487 28,32,33 ; rs11196205 28,32 ; rs11196218 32,34 ; rs12243326 25,29 ; and rs4506565. 25,29 The SNP rs7903146 has been most widely researched, and has been associated with an increased risk of GDM in Scandinavian women 7 .…”

Section: Introductionmentioning

confidence: 99%

Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis

Chang

Wang

et al. 2017

J of Diabetes Invest

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Aims/IntroductionStudies have been carried out to evaluate the correlation between TCF7L2 genetic polymorphisms and gestational diabetes mellitus (GDM) risk. However, the conclusions from these studies are incomplete, because partial single nucleotide polymorphisms (SNPs) were analyzed. We carried out a meta‐analysis aimed to systematically evaluate TCF7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research.Materials and MethodsPublished studies censoring TCF7L2 variants and GDM risk were captured from the EMBASE, PubMed, CNKI and Wanfang databases. The meta‐analysis was processed using software of RevMan 5.2 and Stata13. The relationship between TCF7L2 polymorphism and GDM occurrence was evaluated by pooled odds ratios. Stratified analysis based on race/ethnicity was also carried out. The allele‐specific odds ratios and 95% confidence intervals were counted, and based on homogeneity evaluated using the I 2‐test, fixed‐ or random‐effects pooled measures were selected.ResultsA total of 22 studies were covered, capturing eight TCF7L2 SNPs and involving 5,573 cases and 13,266 controls. Six of eight SNPs showed significant relationships with GDM occurrence, of which the SNPs rs7903146, rs12255372 and rs7901695 were the most powerful. Stratified analysis by race/ethnicity showed discrepant results in these three SNPs. In Caucasians and other races, all these SNPs were found to have a significant association with GDM risk, but in Asians, only SNP rs7903146 showed a significant association.ConclusionsSix of eight SNPs were found to have significant associations between TCF7L2 variants and GDM risk in the overall population, with the most powerful in SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups.

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Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis

He,

Zhang,

Ren

et al. 2024

BMC Pregnancy Childbirth

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Background The association between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus (GDM) has been explored in diverse populations across different geographical regions. Yet, most of these studies have been confined to a limited number of loci, resulting in inconsistent findings. In this study, we conducted a comprehensive review of published literature to identify studies examining the relationship between TCF7L2 and CAPN10 gene polymorphisms and the incidence of GDM in various populations. We specifically focused on five loci that were extensively reported in a large number of publications and performed a meta-analysis. Methods We prioritized the selection of SNPs with well-documented correlations established in existing literature on GDM. We searched eight Chinese and English databases: Cochrane, Elton B. Stephens. Company (EBSCO), Embase, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, and China Science and Technology Journal Database and retrieved all relevant articles published between the inception of the database and July 2022. The Newcastle Ottawa Scale (NOS) was used to evaluate the selected articles, and the odds ratio (OR) was used as the combined effect size index to determine the association between genotypes, alleles, and GDM using different genetic models. Heterogeneity between the studies was quantified and the I2 value calculated. Due to large heterogeneities between different ethnic groups, subgroup analysis was used to explore the correlation between genetic polymorphisms and the incidence of GDM in the different populations. The stability of the results was assessed using sensitivity analysis. Begg’s and Egger’s tests were used to assess publication bias. Results A total of 39 articles reporting data on 8,795 cases and 16,290 controls were included in the analysis. The frequency of the rs7901695 genotype was statistically significant between cases and controls in the European population (OR = 0.72, 95% CI: 0.65–0.86) and the American population (OR = 0.61, 95% CI: 0.48–0.77). The frequencies of rs12255372, rs7901695, rs290487, and rs2975760 alleles were also considerably different between the cases and controls in the populations analyzed. Conclusions rs7903146, rs12255372, rs7901695, rs290487, and rs2975760 were associated with the incidence of GDM in different populations.

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Does TCF7L2 polymorphisms increase the risk of gestational diabetes mellitus in South Indian population?

Cited by 7 publications

References 0 publications

Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis

Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis

Association between TCF7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis

Correlation between TCF7L2 and CAPN10 gene polymorphisms and gestational diabetes mellitus in different geographical regions: a meta-analysis

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