Does T4-Toxicosis Exist ?

Hadden, David R.; McMaster, A. M.; Bell, Tom; Weaver, J. A.; Montgomery, D. A. D.

doi:10.1016/s0140-6736(75)91673-6

Cited by 11 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this condition, serum T4 levels are reported to be elevated whilst serum T3 levels are within the euthyroid range. This condition has been described as one extreme of a spectrum of thyroid hormone concentrations seen in thyrotoxicosis (Hadden et al, 1975). In attempting to mimic this situation, we investigated the effect of raising serum T4 to just within the thyrotoxic range (1.97XIO-'mol or I5 pg/dl), whilst maintaining serum total T3 at the mid-point of the euthyroid range.…”

Section: Discussionmentioning

confidence: 99%

A New Theoretical Description of the Binding of Thyroid Hormones by Serum Proteins

Princé

Ramsden

1977

Clinical Endocrinology

View full text Add to dashboard Cite

A theoretical model is proposed which describes the binding of thyroid hormones to serum proteins in terms of easily determined parameters, Not only free hormone concentration but also the distribution of hormone among various binding sites may be computed. The mathematical approach is capable of dealing with models of differing complexity of binding from simple 'one binding site per protein molecule' systems to those involving 'negative co-operativity'. The approach gives predictions of thyroid function parameters which are in good agreement with those observed in practice.

show abstract

Section: Discussionmentioning

confidence: 99%

A New Theoretical Description of the Binding of Thyroid Hormones by Serum Proteins

Princé

Ramsden

1977

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…The serum thyroxine-binding globulin (TBG) level was 2.8 mg/dL (normal, 18 to 32 µg/mL). The total and free T3 levels were 181 ng/dL (2.8 nmol/L) and 478 pg/dL (normal, 190 to 580 pg/dL), respectively, and the T3/T4 ratio was 13.1.…”

Section: Report Of a Casementioning

confidence: 99%

A Case of Thyroxine Thyrotoxicosis

Blank¹

1987

Arch Intern Med

View full text Add to dashboard Cite

The Diagnostic Dilemma of Isolated Hyperthyroxinemia in Acute Illness

Gavin¹

1979

JAMA

View full text Add to dashboard Cite

Eighteen patients with a variety of illnesses but no history of thyroid disease were shown to have elevated serum total and free thyroxine (T4) concentrations but low serum total triiodothyronine (T3) levels. Thyroid function tests were requested initially to excluded the possibility of hyperthyroidism in a setting of hypermetabolism. Clinical and laboratory follow-up investigations demonstrated that 15 patients were euthyroid and that hormonal alterations were transient features of the intercurrent illnesses. Three patients did, in fact, have hyperthyroidism. Retrospective analysis of diagnostic data demonstrated that of the initial thyroid function screening tests, serum total T3 concentration, the T3/TF4 ratio, and the indirectly measured free T3 (FT3) index were the most useful parameters in excluding hyperthyroidism. The FT3 index was the most helpful, being normal or low in all the euthyroid and high in each of the hyperthyroid patients.

show abstract

Does T4-Toxicosis Exist ?

Cited by 11 publications

References 5 publications

A New Theoretical Description of the Binding of Thyroid Hormones by Serum Proteins

A New Theoretical Description of the Binding of Thyroid Hormones by Serum Proteins

A Case of Thyroxine Thyrotoxicosis

The Diagnostic Dilemma of Isolated Hyperthyroxinemia in Acute Illness

Contact Info

Product

Resources

About