Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Ali, Badreldin H.; Al-Salam, Suhail; Za’abi, Mohammed Al; Balushi, Khalid A. Al; Ramkumar, Aishwarya; Waly, Mostafa I.; Yasin, Javid; Adham, Sirin A.

doi:10.1371/journal.pone.0102528

Cited by 15 publications

(24 citation statements)

References 37 publications

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“…Adenine -induced CKD was associated with a significant rise in several pro-inflammatory cytokines and a reduction in pro-antiinflammatory cytokines, as was reported before [20,23,24]. The three graded doses of chrysin used have not affected the levels of the measured cytokines in control rats.…”

Section: Discussionsupporting

confidence: 72%

Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

Ali

Za’abi

Adham

et al. 2016

Cell Physiol Biochem

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Background/Aims: To study the therapeutic effect of chrysin, a flavonoid with strong antioxidant and anti-inflammatory activities, on adenine-induced chronic kidney diseases (CKD) in rats. Methods: Chrysin, in three graded oral doses (10, 50 and 250 mg/kg), was given for 10 consecutive days to rats after the induction of CKD by feeding them adenine (0.25%^w/w for 35 days). Several plasma and urine biomarkers and tissues morphology were used the investigate chrysin effect on kidney structure and function. Results: Adenine lowered creatinine clearance and elevated the concentrations of urea, creatinine, plasma neutrophil gelatinase-associated lipocalin and urinary N-Acetyl-beta-D-glucosaminidase activity, and increased the concentrations of the uremic toxin indoxyl sulfate, in addition to some inflammatory cytokines. Renal histopathological markers of inflammation and fibrosis were significantly increased. Renal catalase and superoxide dismutase activities, total antioxidant capacity and reduced glutathione were all adversely affected. Most of these adenine - induced actions were moderately mitigated by chrysin, especially at the highest dose. Compared to control, chrysin did not cause any overt adverse effects on the treated rats. Conclusion: Different doses of chrysin produce variable therapeutic salutary effects in rats with CKD, and that, pending further studies, its usability as a possible therapeutic agent in human CKD should be considered.

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Section: Discussionsupporting

confidence: 72%

Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

Ali

Za’abi

Adham

et al. 2016

Cell Physiol Biochem

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“…Different exercise modalities, including SE, have been reported to be beneficial in CKD and its cardiovascular and other related complications in human patients [45–48] and experimental animals [18, 26]. In addition to correcting the imbalance between the generation of reactive oxygen species and the antioxidant defense systems, the basis of these purported benefits may also be related to delaying the occurrence of hypertension and/or decreasing its level by central and peripheral neurohumoral mechanisms [49].…”

Section: Discussionmentioning

confidence: 99%

The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon

et al. 2017

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Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents’ curcumin or lisinopril might offer additional nephroprotection.

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“…Male Wistar rats (9–10 weeks old, initially weighting about 245 g) were obtained from the Animal Facility of Sultan Qaboos University (SQU), and housed in a room at a temperature of 22±2°C, relative humidity of about 60%, with a 12 h light–dark cycle (lights on at 6:00 am), with free access to standard pellet chow diet containing 0.85% phosphorus, 1.12% calcium, 0.35% magnesium, 25.3% crude protein and 2.5 IU/g vitamin D3 (Oman Flour Mills, Muscat, Oman) and tap water. Procedures involving animals and their care were conducted as described before [ 22 ] and an ethical approval from University Animal Research Ethics Committee was obtained (SQU/AEC/13/01).…”

Section: Methodsmentioning

confidence: 99%

“…The biochemical renal function tests in plasma and urine were measured using an automated analyzer as described before [ 22 – 23 ], except for plasma concentration of indoxyl sulfate (IS), which was assayed using an HPLC method, as previously described [ 24 ], and renal antioxidant and neutrophil gelatinase-associated lipocalin (NGAL), N -acetyl-β-D-glucosaminidase (NAG), and sclerostin, which were measured using ELISA.…”

Section: Methodsmentioning

confidence: 99%

“…In the present work, and in continuation of our research program aiming at identifying novel agents for either the prevention or amelioration of adenine–induced CRD in a rat model [ 9 , 12 , 22 – 23 ], we have studied here the effects of treatment with this polyphenolic compound on rats with adenine–induced CRF, using several conventional and novel physiological, biochemical, immunological and histopathological methods, with a special focus on the possible effects of chrysin on the anti-inflammatory and antioxidant mechanisms in adenine – induced CKD.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

et al. 2015

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Chrysin (5, 7- dihydroxyflavone) is a flavonoid with several pharmacological properties that include antioxidant, anti-inflammatory and antiapoptotic activities. in this work, we investigated some effects of three graded oral doses of chrysin (10, 50 and 250 mg/kg) on kidney structure and function in rats with experimental chronic renal disease (CKD) induced by adenine (0.25% w/w in feed for 35 days), which is known to involve inflammation and oxidative stress. Using several indices in plasma, urine and kidney homogenates, adenine was found to impair kidney function as it lowered creatinine clearance and increased plasma concentrations of creatinine, urea, neutrophil gelatinase-associated lipocalin and N-Acetyl-beta-D-glucosaminidase activity. Furthermore, it raised plasma concentrations of the uremic toxin indoxyl sulfate, some inflammatory cytokines and urinary albumin concentration. Renal morphology was severely damaged and histopathological markers of inflammation and fibrosis were especially increased. In renal homogenates, antioxidant indices, including superoxide dismutase and catalase activities, total antioxidant capacity and reduced glutathione were all adversely affected. Most of these adenine – induced actions were moderately and dose -dependently mitigated by chrysin, especially at the highest dose. Chrysin did not cause any overt adverse effect on the treated rats. The results suggest that different doses of chrysin produce variable salutary effects against adenine-induced CKD in rats, and that, pending further pharmacological and toxicological studies, its usability as a possible ameliorative agent in human CKD should be considered.

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Does Swimming Exercise Affect Experimental Chronic Kidney Disease in Rats Treated with Gum Acacia?

Cited by 15 publications

References 37 publications

Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

Therapeutic Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

The effect of swimming exercise on adenine-induced kidney disease in rats, and the influence of curcumin or lisinopril thereon

Ameliorative Effect of Chrysin on Adenine-Induced Chronic Kidney Disease in Rats

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