Does Sucrose Damage Kidneys?

Li, M. K.; Kavanagh, John P.; Prendiville, V.; Buxton, Alfred E.; Moss, D. G.; Blacklock, N. J.

doi:10.1111/j.1464-410x.1986.tb09082.x

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…2 , 30 Specifically, ACH, bradykinins, and adenosine can increase the production of NO from the endothelium to induce vasodilation. 31 , 32 By contrast, the substances inducing vascular dilation are not produced by the endothelium in EIV, such as SNP, which offers exogenous NO to induce vascular dilation. 33 In accordance with these classic principles, we used ACH and SNP respectively to test EDV and EIV of the aortic segments.…”

Section: Discussionmentioning

confidence: 99%

Regular transient limb ischemia protects endothelial function against hypercholesterolemic damage in rabbits

et al. 2021

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Regular transient limb ischemia (RTLI) can prevent atherosclerosis in hypercholesterolemic rabbits. As endothelial dysfunction is the initial factor leading to atherosclerosis, we investigated the effect of RTLI on endothelial function in hypercholesterolemic rabbits. We randomly allocated 15 New Zealand white rabbits to three groups, five animals per group: the hypercholesterolemic group (Group H), the sham RTLI group (Group S), and the RTLI group (Group L). All rabbits received hypercholesterolemic fodder daily. No intervention was performed on the rabbits in Group H. Rabbits in Group S were kept in hutches, with a deflated cuff applied to their left hind limb for 60 min every day. For rabbits in Group L, RTLI (six cycles of 5-min ischemia and 5-min reperfusion of the left hind limb) was applied once daily for 12 weeks. At the end of week 12, a segment of the abdominal aorta was isolated from each rabbit for in vitro measurement of the endothelium-dependent vasodilation (EDV) response to different concentrations of acetylcholine and the endothelium-independent vasodilation (EIV) response to sodium nitroprusside. The EDV response was significantly higher in Group L than in Groups S and H ( p < 0.05), with no significant difference between Groups S and H ( p > 0.05). There was no difference in the EIV response among the three groups. RTLI could improve the EDV response, protecting endothelial function against hypercholesterolemic damage.

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