Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary

Adeghate, Jennifer; Juhász, Emese; Pongrácz, Júlia; Rimanóczy, Éva; Kristóf, Katalin

doi:10.1556/030.63.2016.1.4

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Escherichia coli has been demonstrated to be the most common uropathogen among the female population in the studied group, with an overall prevalence of 58.37%, with a higher incidence at EUH-70.25%, than BCH-52.91%, or MCH-46.15%. Similarities in frequency were also observed in UTIs involved in female patients, as other recent papers from European countries such as Italy-53.5% [29] and Hungary-42.5% [30] have previously reported. Higher percentages were obtained in the ARESC multicenter study, which involved nine European countries and Brazil.…”

Section: Differences and Trends Regarding The Prevalence Of Uropathogenssupporting

confidence: 88%

Spectrum and Antibiotic Resistance of Uropathogens in Romanian Females

et al. 2020

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Urinary tract infections (UTIs) in women represent a common bacteriological finding, with negligible recent and consistent research on antimicrobial resistance (AMR) in the female population. We designed a retrospective study to observe the incidence of frequent uropathogens and their resistance rates to common antibiotics. We elaborated multicenter research in three different teaching hospitals in Romania, analyzing 13,081 urine samples, of which 1588 met the criteria of inclusion. Escherichia coli (58.37%) was the most frequent Gram-negative uropathogen, presenting high resistance rates to levofloxacin (R = 29.66%), amoxicillin–clavulanic ac. (R = 14.13%), and ceftazidime (R = 6.68%). We found good sensitivity to imipenem and meropenem (both 98.16%), amikacin (S = 96.0%), and fosfomycin (S = 90.39%). The second most prevalent uropathogen was Klebsiella (16.93%), with the highest resistance quota to amoxicillin–clavulanic ac. (R = 28.62%), levofloxacin and nitrofurantoin (both R = 15.61%), and ceftazidime (R = 15.24%), and good sensitivity to imipenem (S = 93.93%), meropenem (S = 91.91%), and amikacin (S = 88.47%). Enterococcus (13.35%) was the most encountered Gram-positive pathogen. It proved the highest resistance to levofloxacin (R = 32.07%), penicillin (R = 32.07%), and ampicillin (R = 14.62%) and good sensitivity to vancomycin (S = 91.98%), fosfomycin (S = 94.4%), and nitrofurantoin (S = 89.15%). Considering the lack of recent and consistent data on this topic, we find our survey a valuable starting research study in this area with high significance for an accurate clinical approach.

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Section: Differences and Trends Regarding The Prevalence Of Uropathogenssupporting

confidence: 88%

Spectrum and Antibiotic Resistance of Uropathogens in Romanian Females

et al. 2020

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“…In contrast, S. saprophyticus is a well-characterized pathogen in both uncomplicated cystitis and catheter-associated UTIs. The pathogenic role of S. saprophyticus in UTIs (sometimes referred to as “honeymoon cystitis”) was described in the 1960s and since then, more and more evidence was found regarding the pathogenesis of this disease 17 . Most of epidemiological studies estimate S. saprophyticus as causative agents in 5–20% of UTIs, however, a study from Sweden found that this pathogen was the etiological agent in > 40% of uncomplicated UTIs in females 18 .…”

Section: Introductionmentioning

confidence: 99%

“…Similarly to S. aureus , these pathogens are relevant in nosocomial infections worldwide 23 . Temporal changes in the occurrence of Gram-positive cocci in UTIs have been described, two peaks (one in early summer, the other in the winter months) were observed in multiple studies 17 , 18 . The role of companion animals as reservoirs of S. aureus and Enterococcus spp.…”

Section: Introductionmentioning

confidence: 99%

Increasing relevance of Gram-positive cocci in urinary tract infections: a 10-year analysis of their prevalence and resistance trends

Gajdács

Ábrók

Lázár

et al. 2020

Sci Rep

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Urinary tract infections (UTIs) are the third most common types of infection in human medicine worldwide. There is increasing appreciation for the pathogenic role of Gram-positive cocci (GPC) in UTIs, as they have a plethora of virulence factors, maintaining their pathogenicity and high affinity for the epithelial cells of the urinary tract. The study was carried out using microbiological data collected corresponding to the period between 2008 and 2017. Antimicrobial susceptibility testing was performed using the disk diffusion method and E-tests. The age range of patients affected from the outpatient and inpatient groups differed significantly (43 [range 0.7–99] vs. 68 [range 0.4–99] years; p = 0.008). 3962 GPCs were obtained from inpatient and 4358 from outpatient samples, corresponding to 20.5 ± 2.8% (range 17.5–26.8%) and 20.6 ± 2.6% (range 17.8–26.0%) of all positive urine samples (p > 0.05); in both groups, Enterococcus spp. were the most prevalent (outpatients: 79.6%; inpatients: 88.5%). High-level aminoglycoside resistance in enterococci was noted in 31.0–46.6% of cases. A pronounced increase in the number of MRSA was seen in the second half of the study period (0.6–1.9% vs. 9.8–11.6%; p = 0.038). The ratio of VRE isolates was 0.16%, no VISA/VRSA isolates were detected.

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“…saprophyticus was higher in the 2010–2011 and 2013–2015 cohorts, which was expected as these two groups consisted of younger women. 25–26…”

Section: Discussionmentioning

confidence: 99%

Bacteriology in uncomplicated urinary tract infections in Norwegian general practice from 2001–2015

Bollestad¹,

Vik²,

Grude³

et al. 2017

BJGP Open

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BackgroundUncomplicated urinary tract infections in women are common, and urine samples from these patients are not routinely cultured. Empirical treatment is based on knowledge of resistance patterns for common uropathogens.AimTo evaluate the bacteriological findings and resistance patterns in urine samples from women with uncomplicated urinary tract infections, and to assess the relationship between antimicrobial use and resistance patterns from 2000–2015 in Norway.MethodBacteriology and resistance patterns were compared in 184 urine cultures from 2001, 406 urine cultures from 2010–2011 and 259 urine cultures from 2013–2015. Antibiotic use data from 2000–2015 were obtained from national databases.Results Escherichia coli (E. coli) was the main bacterial agent in 80% of the cultures. Staphylococcus saprophyticus (Staph. saprophyticus) represented 6–17%. For E. coli, resistance to mecillinam showed some variation but remained below 9%. There was negligible resistance to nitrofurantoin. Resistance to trimethoprim seemed to stabilise over the last 5 years at around 20%. Amoxicillin resistance had some variations, but remained stable around 30%. There was a steady rise in total consumption of selected antibiotics commonly used to treat urinary tract infections for the period 2000–2015.ConclusionMecillinam and nitrofurantoin are both excellent first choices for empirical treatment of uncomplicated urinary tract infections. This study suggests that increasing resistance to trimethoprim challenges the rationale for its use as a first-line agent.

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Does Staphylococcus Saprophyticus Cause Acute Cystitis only in Young Females, or is there more to the Story? A One-Year Comprehensive Study Done in Budapest, Hungary

Cited by 10 publications

References 13 publications

Spectrum and Antibiotic Resistance of Uropathogens in Romanian Females

Spectrum and Antibiotic Resistance of Uropathogens in Romanian Females

Increasing relevance of Gram-positive cocci in urinary tract infections: a 10-year analysis of their prevalence and resistance trends

Bacteriology in uncomplicated urinary tract infections in Norwegian general practice from 2001–2015

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