Does Spinal Analgesia have Advantage over General Anesthesia for Achieving Success in In-Vitro Fertilization?

Aghaamoo, Shahrzad; Azmoodeh, Azra; Yousefshahi, Fardin; Berjis, Katayon; Ahmady, Farahnazsadat; Qods, Kamran; Mirmohammadkhani, Majid

doi:10.5001/omj.2014.24

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…Recent trials concluded that the use of spinal anesthesia improves IVF outcome [ 1 , 2 ]. Spinal anesthesia increased significantly the chance of IVF success in a randomized prospective trial by Azmude et al in 2013 [ 1 ].…”

Section: Resultsmentioning

confidence: 99%

“…Spinal anesthesia increased significantly the chance of IVF success in a randomized prospective trial by Azmude et al in 2013 [ 1 ]. According to a cohort study based on analysis of patient records at Mirza Kochak Khan Hospital, Tehran University of Medical Sciences (Aghaamoo et al, 2014), it was recommended to use spinal anesthesia instead of GA for oocyte retrieval, to achieve successful in vitro fertilization outcome [ 2 ]. Nerve blocks (ovarian block and paracervical block) as an additional method for pain relief proved no harm on the IVF success [ 3 , 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two studies comparing general anesthesia (GA) with spinal anesthesia (SA) proved that SA had an advantage on IVF success. Women undergoing SA had increased pregnancy rates compared with women who received GA for IVF [ 1 , 2 ]. Epidural anesthesia and sedation (propofol and mask-assisted ventilation with nitrous oxide) had the same outcomes in terms of pregnancy [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

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Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Matsota

Kaminioti

Kostopanagiotou

2015

BioMed Research International

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Management of pain and anxiety during oocyte retrieval makes anesthesia an important part of the in vitro fertilization (IVF) procedures. There are many studies investigating the influence of anesthesia on IVF success. This review article provides an overview of published data regarding the potential toxic effects of different anesthetic techniques (Loco-regional, general anesthesia (GA), and monitored anesthesia care (MAC)), different anesthetic agents, and alternative medicine approach (principally acupuncture) on the IVF outcome. From our analysis, evidence of serious toxicity in humans is not well established. Trials regarding different anesthetic techniques ended up without clear conclusions. Studies about GA came up with conflicting results. A few trials relate GA with lower pregnancy rates, although some others failed to prove this conclusion. Furthermore, detectable amounts of some anesthetic agents are measurable in the follicular fluid but these findings are not strongly associated with toxicity. MAC and Loco-regional anesthesia appear as safe alternative choices and there is evidence of improved outcome. Whereas acupuncture may provide assistance increasing IVF success according to some trials, some others could not obtain these effects. Questions about the appropriate time of application and the underlying mechanism of action are not answered yet, so further investigation should be done.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Matsota

Kaminioti

Kostopanagiotou

2015

BioMed Research International

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“…Although there have been fewer studies related to inhalation agents, it has been reported that halotane and isoflurane in particular have harmful effects on oocytes through the transfer of follicular fluid. However, it should be noted that they were animal studies and the surgical procedures applied were lengthy laparoscopic OPU methods [18][19][20]. Piroli et al reported similar high rates of fertilisation using general anaesthesia with sevoflurane and with local anaesthesia methods in transvaginal OPU procedure [21].…”

Section: Discussionmentioning

confidence: 99%

Effect of Anesthetics During Oocyte Pick-Up Procedure on Oocyte Quality and Pregnancy

Urfalıoğlu¹

2016

Ann Clin Anal Med

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“…The procedure necessitates a short-acting anesthetic approach with minimal side-effects. The various anesthetic modalities used for transvaginal oocyte retrieval include monitored anesthesia care, conscious sedation, general anesthesia, regional anesthesia, local injection as a paracervical block, epidural block, subarachnoid block, total intravenous anesthesia, patient-controlled analgesia, and acupuncture [4,5,6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the applied technique of intravenous anesthesia for in vitro fertilization in obese and patients with normal body mass index

Videnović¹,

Mladenović²,

Pavlović³

et al. 2019

Srp Arh Celok Lek

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Introduction/Objective In this study, the effects of applied anesthetic techniques were investigated in a retrospective analysis of obese patients and those with normal body mass index undergoing in vitro fertilization, using bispectral index as an indicator of anesthetic depth. Methods In total 116 patients with normal body mass index were allocated to group N. Another 116 patients with body mass index > 30 kg/m 2 were allocated to group O. Anesthetic protocol comprised midazolam for premedication, diclofenac for pre-emptive analgesia, propofol for induction and maintenance, alfentanil for analgesia, suxamethonium for muscle relaxation. We recorded and compared the monitored parameters using t-test and χ 2 test. Results Procedure duration and recovery time were significantly longer in O group (p < 0.01). There is a statistically significant difference (p = 0.000181) in the number of patients requiring mechanical ventilation after induction of anesthesia. Propofol consumption was significantly higher (p < 0.0001) in O group (2.7 ± 1.6 mg/kg) as compared to group N (2.1 ± 0.4 mg/kg). The incidence of postoperative nausea and vomiting was observed in six patients in N group (5.17%) and nine patients in O group (7.76%). Pain intensity was found higher in group O compared to group N (p < 0.0001). Assessment of patients' sedation using verbal scale reported no statistically significant difference between N and O groups (p = 0.2548). Conclusion Induction and maintenance of anesthesia in obese patients results in increased consumption of propofol and the need for muscle relaxation. The statements of the patients who underwent the procedure under intravenous propofol and alfentanil serve as the best recommendation for clinical practice.

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Does Spinal Analgesia have Advantage over General Anesthesia for Achieving Success in In-Vitro Fertilization?

Cited by 11 publications

References 20 publications

Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Anesthesia Related Toxic Effects on In Vitro Fertilization Outcome: Burden of Proof

Effect of Anesthetics During Oocyte Pick-Up Procedure on Oocyte Quality and Pregnancy

Analysis of the applied technique of intravenous anesthesia for in vitro fertilization in obese and patients with normal body mass index

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