Does soil track-in contribute to house dust concentrations of perfluoroalkyl acids (PFAAs) in areas affected by soil or water contamination?

Scher, Deanna; Kelly, James E.; Huset, Carin A.; Barry, Kitrina M.; Yingling, Virginia

doi:10.1038/s41370-018-0101-6

Cited by 9 publications

(5 citation statements)

References 43 publications

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“…PFOA has been detected in house dust, [ 4 ] surface and drinking water, [ 5 , 6 ], indoor and outdoor air [ 7 ], and animal tissues [ 8 , 9 ]. Humans are exposed to PFOA through diet, primarily eggs, fish products, poultry products, cereals, vegetables and drinking water, inhalation of dust particles, and in commercial products [ 5 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Rashid

Ahmad

Irudayaraj

2020

Toxics

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Perfluorooctanoic acid (PFOA) has been implicated in various toxicities including neurotoxicity, genotoxicity, nephrotoxicity, epigenetic toxicity, immunotoxicity, reproductive toxicity, and hepatotoxicity. However, information on the accumulation of PFOA in the intestine and its toxic effects on intestinal epigenetics and tight junction (TJ) genes is sparse. CD1 mice were dosed with PFOA (1, 5, 10, or 20 mg/kg/day) for 10 days, and its accumulation and induced alterations in the expression of epigenetic and tight junction genes in the small intestine and colon were evaluated using LC–MS and qPCR techniques. PFOA reduced the expression levels of DNA methyltransferases (Dnmt1, Dnmt3a, Dnmt3b) primarily in the small intestine whereas, in the colon, a decrease was observed only at high concentrations. Moreover, ten-eleven translocation genes (Tet2 and Tet3) expression was dysregulated in the small intestine, whereas in the colon Tets remained unaffected. The tight junction genes Claudins (Cldn), Occludin (Ocln), and Tight Junction Protein (Tjp) were also heavily altered in the small intestine. TJs responded differently across the gut, in proportion to PFOA dosing. Our study reveals that PFOA triggers DNA methylation changes and alters the expression of genes essential for maintaining the physical barrier of intestine, with more profound effects in the small intestine compared to the colon.

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Section: Introductionmentioning

confidence: 99%

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Rashid

Ahmad

Irudayaraj

2020

Toxics

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“…To provide some context to the results summarized above, average levels of PFAS measured at each site were compared to average dust levels reported in other U.S.-based studies (with or without known PFAS contamination). This includes evaluations of indoor dust collected at 30 homes in the greater Boston area [Fraser et al 2013], 124 homes in California [Wu 2015], 15 U.S. homes [Karásková et al 2016], and 19 homes in Minnesota cities with PFAS-contaminated soil and drinking water [Scher et al 2018]. Across these studies and in this EA, PFOA and PFOS were consistently reported at the highest concentrations.…”

Section: Pfas In Household Dust At Atsdr-led Easmentioning

confidence: 89%

“…Participants were instructed not to vacuum carpeting or sweep floors for five days prior to the scheduled visit. Adapting methods described inScher et al [2018], ATSDR collected dust samples using a high-volume air sampler connected to an open-faced 37-millimeter filter cassette with an 0.8 micron filter. A wooden 2 square foot (ft 2 ) sampling template was used to mark off each sampling area.…”

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confidence: 99%

PFAS Exposure Assessments Final report

2022

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"PFAS (or per- and polyfluoroalkyl substances) are a family of synthetic chemicals that have been used in industry and consumer products since the 1940s. There are thousands of different PFAS. The exposure assessments (EAs) described in this report evaluated some of the most commonly studied PFAS, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnA), and N-methyl perfluorooctanesulfonamidoacetic acid (MeFOSAA)"

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“…For PFAAs, concentrations in the fire station living room dust samples were generally lower than previous studies of dust in U.S. homes or offices, although these environments are not directly comparable (Table S3). 30,47,[64][65][66][67][68][69] Only one living room in this study had carpet, which is an important source of PFAAs indoors. 13,47,67 In addition, those studies did not measure the three most frequently detected chemicals in this study's samples-N-EtFOSAA, 6:2 FtS, and 8:2 FtS-which were found at higher concentrations than in previous European studies.…”

Section: Discussionmentioning

confidence: 99%

Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust

Young

Sparer-Fine

Pickard

et al. 2021

J Expo Sci Environ Epidemiol

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Per-and polyfluoroalkyl substances (PFAS) are a class of over 4,700 fluorinated compounds used in industry and consumer products. Studies have highlighted use of aqueous film-forming foams (AFFFs) as an exposure source for firefighters, but little is known about PFAS occurrence inside fire stations, where firefighters spend most of their shifts. In this study, we aimed to characterize PFAS concentrations and sources inside fire stations. We measured 24 PFAS (using LC-MS/MS) and total fluorine (using particle-induced gamma ray emission) in dust from multiple rooms of 15 Massachusetts stations, many of which (60%) no longer use PFAS-containing AFFF at all and the rest of which only use it very rarely. Compared to station living rooms, turnout gear locker rooms had higher dust levels of total fluorine (p<0.0001) and three PFAS: perfluorohexanoate (PFHxA), perfluoroheptanoate (PFHpA), and perfluorodecanoate (PFDoDA) (p<0.05). These PFAS were also found on six wipes of station turnout gear. By contrast, the dominant PFAS in living rooms was N-ethyl perfluorooctane sulfonamidoacetic acid (N-MeFOSAA), a precursor to perfluorooctane sulfonate (PFOS) that still persists despite phase-outs almost two decades ago. The Σ 24 PFAS accounted for less than 2% of fluorine in dust (n=39), suggesting the potential presence of unknown PFAS. Turnout gear may be an important PFAS source in stations due to intentional additives and/or contamination from firefighting activities.Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:

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Does soil track-in contribute to house dust concentrations of perfluoroalkyl acids (PFAAs) in areas affected by soil or water contamination?

Cited by 9 publications

References 43 publications

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

Effect of Perfluorooctanoic Acid on the Epigenetic and Tight Junction Genes of the Mouse Intestine

PFAS Exposure Assessments Final report

Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust

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