Does single-strand DNA break repair capacity influence oocyte maintenance and quality?

Abstract

Human genome-wide association studies and evidence from animal models link ovarian ageing to double-stranded (ds) DNA break repair capacity. Is there a connection between single-stranded (ss)DNA repair mechanisms and ovarian function? We hypothesize that endogenous cellular processes subject oocytes to ssDNA lesions and thus, ssDNA repair capacity is fundamental to their survival and maintenance.

Оксидативний Стрес – Обов'язковий Учасник Патогенезу Стрес-Індукованих Розладів Репродукції

“…ROS interact with purine and pyrimidine bases of DNA, some metabolites of which are able to break DNA chains, which creates conditions for teratogenesis. Endogenous single-stranded DNA break repair mechanisms are important for egg preservation [23], but they are not able to resist ROS in case of their excessive formation. Free radicals attack eggs, change their microenvironment (follicular fluid, granulosa zone, etc.…”