Does Sex-Differential Gene Expression Drive Sex-Differential Selection in Humans?
Matthew J. Ming,
Changde Cheng,
Mark Kirkpatrick
et al.
Abstract:Sex differences in human transcriptomes have been argued to drive sex-differential natural selection (SDS). Here, we show that previous evidence supporting this hypothesis has been largely unfounded. We develop a new method to test for a genome-wide relationship between sex differences in expression and selection on expression-influencing alleles (eQTLs). We apply it across 39 human tissues and find no evidence for a general relationship. We offer possible explanations for the lack of evidence, including that … Show more
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