Does severity of ischemic coronary disease correlate with erectile function?

Greenstein, Alexander; Chen, J; Miller, Hylton I.; Matzkin, Haim; Villa, Yael; Braf, Z

doi:10.1038/sj.ijir.3900282

Cited by 262 publications

(172 citation statements)

References 6 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…This is supported by the facts that ED and ischemic heart disease share the same risk factors, 6 ± 8 that cavernous tissues of ED patients are similar to those of atherosclerosis, 9,10 and that erectile function shows an inverse correlation with the severity of ischemic heart disease. 11 Thus, it is no coincidence that arterial ED patients have symptomatic or asymptomatic ischemic heart disease.…”

Section: Discussionmentioning

confidence: 99%

Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients

et al. 2001

View full text Add to dashboard Cite

Erection is a hemodynamic event and accordingly, erectile dysfunction (ED) is closely related with ischemic heart disease. We should con®rm that the cardiac condition of the ED patient is safe enough to perform sexual intercourse prior to beginning treatment for ED. Asymptomatic ischemic heart disease cannot be diagnosed only in an interview, but it's dif®cult to perform cardiac exercise tests on all patients complaining of ED. Therefore, screening methods to evaluate patients who should undergo exercise tests are needed. Sixty patients with erectile dysfunction participated in this study. Physical examinations, interviews, and color Doppler examinations were conducted. Chest X-rays and electrocardiograms of all patients in the resting position were obtained, as were electrocardiograms following exercise. Echocardiograms, treadmill test results, thallium exercise scintigrams, and coronary angiograms were obtained as required for diagnosis. Two patients were excluded because they had obvious arteriogenic ED due to perineal injury. Fifty-eight patients underwent Doppler evaluations of their cavernous arteries and heart exercise tests. Fourteen patients (24.1%) were diagnosed with ischemic heart disease. Although six of them had already been diagnosed with ischemic heart disease, eight were newly diagnosed by the exercise tests. Cardiovascular risk factors such as advanced age, hyperlipidemia, diabetes mellitus, hypertension, smoking, and obesity were not suf®cient predictive factors. The mean peak systolic velocity of the patients without ischemic heart disease was 34.6 cmas vs 22.0 cmas in those with ischemic heart disease. Only 3.7% of patients whose peak systolic velocity in the cavernous artery was equal to or exceeded 35 cmas had ischemic heart disease. On the other hand, 41.9% of patients with peak systolic velocity of less than 35 cmas had ischemic heart disease. The sensitivity of peak systolic velocity against ischemic heart disease was 92.9%, and speci®city was 59.1%. In ED patients, incidences of complications involving symptomatic or asymptomatic ischemic heart disease were found to be high. The peak systolic velocity in the cavernous artery is thought to be a useful predictive factor of ischemic heart disease in ED patients. When a patient reveals a peak systolic velocity of less than 35 cmas, he should undergo heart exercise tests prior to treatment of ED.

show abstract

Section: Discussionmentioning

confidence: 99%

Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients

et al. 2001

View full text Add to dashboard Cite

show abstract

“…25 Thus, ED may be particularly useful in assessing cardiovascular risk in younger men 26 and in minorities, 27 whose risk may be underestimated by global risk assessments such as the FRS. Finally, assessment of ED must include ED severity because more severe ED has been associated with greater risk of major cardiovascular events, 28 CAD, 23,29 extent of CAD, 19,21,30 and risk of PAD (ACCF/AHA class Ia). 22 These recommendations are supported by a meta-analysis of 12 prospective studies involving 36,744 men (Table 1).…”

Section: Sexual Inquiry Of All Menmentioning

confidence: 99%

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Nehra

Jackson

Miner

et al. 2012

Mayo Clinic Proceedings

406

338

View full text Add to dashboard Cite

The Princeton Consensus (Expert Panel) Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The third Princeton Consensus met November 8 to 10, 2010, and had 2 primary objectives. The first objective focused on the evaluation and management of cardiovascular risk in men with erectile dysfunction (ED) and no known cardiovascular disease (CVD), with particular emphasis on identification of men with ED who may require additional cardiologic work-up. The second objective focused on reevaluation and modification of previous recommendations for evaluation of cardiac risk associated with sexual activity in men with known CVD. The Panel's recommendations build on those developed during the first and second Princeton Consensus Conferences, first emphasizing the use of exercise ability and stress testing to ensure that each man's cardiovascular health is consistent with the physical demands of sexual activity before prescribing treatment for ED, and second highlighting the link between ED and CVD, which may be asymptomatic and may benefit from cardiovascular risk reduction. T he Princeton Consensus Conference is a multispecialty collaborative tradition dedicated to optimizing sexual function and preserving cardiovascular health. The first conference convened in June 1999 to develop recommendations for clinical management of sexual dysfunction in men and women with known cardiovascular disease (CVD). This conference also provided a multidisciplinary forum for evaluation of the potential cardiovascular risk posed by sexual activity in atrisk patients. The first Princeton Consensus Conference recommendations 1 included stratification of patients by level of cardiac risk associated with sexual activity based on existing CVD. Those at low risk could initiate or resume sexual activity and be treated for sexual dysfunction. For those at high risk, sexual activity was deferred until the cardiac condition was stabilized. The second Princeton Consensus Conference convened in June 2004 and expanded the recommendations of the first conference to emphasize risk factor evaluation and lifestyle management for all men with erectile dysfunction (ED). 2 The second conference recommendations also incorporated new information on the appropriate use of phosphodiesterase type 5 (PDE5) inhibitors in men with ED and concomitant CVD.The third Princeton Consensus Conference took place November 8 to 10, 2010, in Miami Beach, Florida. The group revisited and updated their 2005 recommendations regarding the cardiovascular risk associated with sexual activity in men with known CVD. 2 In addition, the third conference focused on the predictive value of vasculogenic ED in assigning cardiovascular risk in men of all ages, with the primary objective being development of an approach to cardiovascular risk assessment in younger men with ED and no known CVD. The role of testosterone in erectile function and cardiovascular health and the utility of testosterone replacement...

show abstract

“…[3][4][5] It is now well established that many risk factors for CAD (hypertension, smoking, dyslipidemia, diabetes mellitus (DM) and lack of physical exercise) are also risk factors for ED; 6,7 at least one significant cardiovascular risk factor occurs in most ED patients. [8][9][10] This could be attributed to the fact that both CAD and ED are characterized by endothelial dysfunction and injury. 11,12 These shared risk factors contribute to endothelial dysfunction and impede vasodilatation, thereby inhibiting the occurrence of normal erection.…”

Section: Introductionmentioning

confidence: 99%

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Chu

et al. 2009

Int J Impot Res

View full text Add to dashboard Cite

We determined the association between the severity of erectile dysfunction (ED) and traditional cardiovascular risk factors, including metabolic syndrome (MS). A total of 141 ED patients were divided into three groups on the basis of ED severity, which was determined using the International Index of Erectile Function (IIEF) scores. The prevalence of MS among the ED patients was 32.6%. Significantly lower IIEF scores were noted in patients with MS than in patients without MS (7.6±6.4 vs 11.6±7.4, P ¼ 0.003). As assessed by the anthropometric indices of body mass index, waist circumference and waist-to-hip ratio, obesity was detected in 58.9, 54.6 and 32.6% of the patients, respectively. Of the 141 patients, 39 had mild, 24 had moderate and 78 had severe ED. Statistically significant differences were noted among the different ED severity groups with regard to the presence of hypertension, systolic blood pressure, presence of MS and number of MS components. Multivariate analysis showed that the odds ratio for high-low-density lipoprotein (LDL) cholesterol level in moderate and severe ED, determined with reference to mild ED, were 9.346 and 6.452, respectively. The presence of MS, number of MS components, and certain traditional cardiovascular risk factors, particularly high-LDL cholesterol level and hypertension, may influence the severity of ED.

show abstract

Does severity of ischemic coronary disease correlate with erectile function?

Cited by 262 publications

References 6 publications

Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients

Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients

The Princeton III Consensus Recommendations for the Management of Erectile Dysfunction and Cardiovascular Disease

Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity

Contact Info

Product

Resources

About