Does Serum Uric Acid Status Influence the Association Between Left Atrium Diameter and Atrial Fibrillation in Hypertension Patients?

Abstract

Objective: Both serum uric acid (SUA) levels and left atrium diameter (LAD) associate with AF. However, the influence of SUA status for the associated risk of AF related to LAD in hypertension patients is currently unknown.Methods: We retrospectively analyzed a hospital-based sample of 9,618 hypertension patients. Standard electrocardiograms were performed on all patients and were interpreted by expert electro-physiologists.Results: Overall 1,028 (10.69%) patients had AF out of 9,618 patients. In men >65 years of age, the prevalence of AF in the1st, 2nd, and 3rd tertiles of SUA among those grouped in the third tertile of LAD were 9, 12.3, and 21.7%, respectively. In the hyperuricemia group, the OR (95% CI) of AF for the highest tertile of LAD in men ≤ 65 years of age was 3.150 (1.756, 5.651; P < 0.001). Similarly, the hyperuricemic men in the 3rd LAD tertile had a higher likelihood of AF than those belonging to the 1st tertile. The ORs and (95% CIs) were 3.150 (1.756, 5.651; P < 0.001) and 5.522 (2.932, 10.400; P ≤ 0.001) for patients ≤ 65 and >65 years of age. An increase in SUA values was significantly associated with an increased likelihood of AF among women at the top tertiles of LAD, with the OR (95% CI) = 4.593 (1.857, 11.358; P = 0.001). Also, men> 65 years of age with large LAD, present at the third tertile of SUA, had a higher likelihood of AF, with the OR (95% CI) = 2.427 (1.039, 5.667; P < 0.05).Conclusion: SUA levels and LAD are associated with AF in patients with hypertension and the risk of AF associated with LAD increases among those with hyperuricemia.

The Distribution of Cardiovascular-Related Comorbidities in Different Adult-Onset Cancers and Related Risk Factors: Analysis of 10 Year Retrospective Data

“…HF was defined based on the presence of symptoms of HF and evidence of at least one echocardiographic abnormality (17). Patients were diagnosed with atrial fibrillation (AF) if they met any of the following criteria: (1) AF pattern in baseline 12lead electrocardiogram (ECG) screening or (2) AF episodes in 24-hour single-lead ECG recording or Holter (18). We defined the first signs of AF during hospitalization as the incident AF cases.…”

Early atrial remodeling predicts the risk of cardiovascular events in patients with metabolic syndrome: a retrospective cohort study

“…Standard two-dimensional echocardiography with Doppler examination was performed, and measurements were obtained according to the guidelines of the American Society of Echocardiography ( 20 ). The left atrium diameter was obtained as previously reported ( 21 ), and LAE was defined on the basis of a posteroanterior dimension >35 mm. The left ventricular mass was measured by echocardiography, and the left ventricular mass index was calculated ( 22 ).…”

A case–control study to investigate association between serum uric acid levels and paroxysmal atrial fibrillation

“…Recently, considerable attention has been obtained to the possible mechanism by which hyperuricemia contributes to AF 14 , 15 . Several studies reported that there was an association between elevated SUA and the risk of AF 16 – 18 , while results remained an inconclusive measurement, possibly due to differences in the study population, confounding factors, or gender. To our knowledge, studies on different subtypes of relationships between SUA levels and AF are limited, and the potential relationship between paroxysmal AF and SUA levels has not been fully elucidated, especially in the Chinese population.…”