Does serum ferritin correlate with coronary angiography findings?

Manfroi, Waldomiro Carlos; Zago, Alcides José; Caramori, Paulo; Cruz, Rosana; Oliveira, Juliana Ghisleni de; Kirschnick, Luciana Schmidt; Ordovás, Karen; Candiago, Rafael Henriques; Souza, Josiane de; Ribeiro, Letícia; Leitão, Cristiane Bauermann; Brizolara, Maria Luiza

doi:10.1016/s0167-5273(99)00020-0

Cited by 10 publications

(4 citation statements)

References 36 publications

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“…Previous studies have found contradictory findings regarding S-Ferritin levels and CVD. [19][20][21][22][23][24][25][26][27][28] In this present study, S-Ferritin was found to be lower in those reporting CVD and therefore does not support the hypothesis that high S-Ferritin could reflect elevated stores of iron that could work as free radicals and be involved in oxidative modification of LDL.…”

Section: Discussioncontrasting

confidence: 76%

“…[20][21][22][23][24] However, other studies have not supported this hypothesis. [25][26][27][28] Similarly, it has been proposed that increased iron might elevate the risk of type 2 diabetes by causing oxidative stress and tissue damage. [29][30][31][32][33] As many OSA patients are obese, have CVD, hypertension and systemic inflammation, one would expect that a marker of inflammation such as S-Ferritin would be elevated in subjects with OSA.…”

Section: Introductionmentioning

confidence: 99%

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Serum ferritin and obstructive sleep apnea—epidemiological study

et al. 2017

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Serum ferritin and obstructive sleep apnea—epidemiological study

et al. 2017

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“…Manfroi et al (1999) [51] studied in 307 patients (60.9% male) the relationship between serum ferritin levels and the presence of coronary atherosclerosis. Of the patients, 196 (63.8%) had angiographic defined CAD and 111 (36.2%) no significant CAD.…”

Section: Studies Which Did Not Find Any Association Between Iron Amentioning

confidence: 99%

Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial

et al. 2013

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Iron is the second most abundant metal in the Earth’s crust. Despite being present in trace amounts, it is an essential trace element for the human body, although it can also be toxic due to oxidative stress generation by the Fenton reaction, causing organic biomolecule oxidation. This process is the basis of numerous pathologies, including cardiovascular diseases (CVD). The relationship between iron and cardiovascular disease was proposed in 1981 by Jerome Sullivan. Since then, numerous epidemiological studies have been conducted to test this hypothesis. The aim of this review is to present the main findings of the chief epidemiological studies published during the last 32 years, since Sullivan formulated his iron hypothesis, suggesting that this element might act as a risk factor for cardiovascular disease. We have analyzed 55 studies, of which 27 supported the iron hypothesis, 20 found no evidence to support it and eight were contrary to the iron hypothesis. Our results suggest that there is not a high level of evidence which supports the hypothesis that the iron may be associated with CVD. Despite the large number of studies published to date, the role of iron in cardiovascular disease still generates a fair amount of debate, due to a marked disparity in results.

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“…Therefore, it is quite possible that the levels of serum ferritin are influenced by inflammation independently of iron stores [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Association of iron overload based quantitative T2* MRI technique and carotid intima-media thickness in patients with beta-thalassemia: A cross-sectional study

Akhlaghpoor

Hoseini

Jafarisepehr

2010

BMC Cardiovasc Disord

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BackgroundBody iron status has been implicated in atherosclerotic cardiovascular disease. The main hypothesis is that high iron status is associated with increased risk of atherosclerosis. We investigated the potential role of iron as an additional risk factor promoting atherosclerosis among beta-thalassemic patients.MethodsIn this cross-sectional study, the liver iron load was assessed by quantitative T2* MRI technique and intima-media thickness (IMT) of the common carotid artery by high-resolution ultrasound among 119 patients (62 male, 57 female) with beta-thalassemia (major and intermediate) whose age ranged from 10 to 50 years with a mean of 25.6 years. The patients were divided into three groups according to the severity of iron loading, obtained by T2*MRI technique: group I (normal), group II (mild) and group III (moderate and severe) iron load.For elimination of the effect of age on carotid IMT values, the patients also were divided into four age groups (10-19 y, 20-29 y, 30-39 y and 40-50 y). Mean carotid IMT based on the severity of iron loading were compared at different age groups, using one way ANOVA analysis for assessing the effect of iron loading on carotid IMT. Pearson's coefficient of correlation were used to assess the degree of correlation between studied variables (liver T2*, IMT, age).ResultsThere were significant differences in mean carotid IMT based on the severity of iron loading at different age groups, with P = 0.003 at 20-29 y, P = 0.006 at 30-39 y and p = 0.037 at 40-50 y. Age (p = 0.001) and liver T2*(p = 0.003) had significant correlation with mean carotid IMT independently.At the age group of 10-19 years, there were not significant differences in mean carotid IMT based on the liver iron loading (p = 0.661).No significant differences also are seen in mean carotid IMT between male and female (p = 0.41).ConclusionsThis study identified a relationship between body iron status and carotid IMT. This relationship support to the hypothesis of a link between body iron load and atherosclerosis.

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Does serum ferritin correlate with coronary angiography findings?

Cited by 10 publications

References 36 publications

Serum ferritin and obstructive sleep apnea—epidemiological study

Serum ferritin and obstructive sleep apnea—epidemiological study

Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial

Association of iron overload based quantitative T2* MRI technique and carotid intima-media thickness in patients with beta-thalassemia: A cross-sectional study

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