2014
DOI: 10.1155/2014/542526
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Does rTMS Alter Neurocognitive Functioning in Patients with Panic Disorder/Agoraphobia? An fNIRS-Based Investigation of Prefrontal Activation during a Cognitive Task and Its Modulation via Sham-Controlled rTMS

Abstract: Objectives. Neurobiologically, panic disorder (PD) is supposed to be characterised by cerebral hypofrontality. Via functional near-infrared spectroscopy (fNIRS), we investigated whether prefrontal hypoactivity during cognitive tasks in PD-patients compared to healthy controls (HC) could be replicated. As intermittent theta burst stimulation (iTBS) modulates cortical activity, we furthermore investigated its ability to normalise prefrontal activation. Methods. Forty-four PD-patients, randomised to sham or verum… Show more

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Cited by 33 publications
(53 citation statements)
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“…In the end, both active and sham rTMS groups showed substantial improvement of PD symptoms, without significant difference between groups. There were no improvements in prefrontal hypoactivity or verbal fluency following iTBS (Deppermann et al, ).…”
Section: Resultsmentioning
confidence: 98%
See 1 more Smart Citation
“…In the end, both active and sham rTMS groups showed substantial improvement of PD symptoms, without significant difference between groups. There were no improvements in prefrontal hypoactivity or verbal fluency following iTBS (Deppermann et al, ).…”
Section: Resultsmentioning
confidence: 98%
“…Two double-blind, randomized, sham-controlled trials evaluated the efficacy of rTMS or iTBS, respectively, as a treatment of PD(Deppermann et al, 2014;Mantovani, Aly, Dagan, Allart, & Lisanby, 2013). One study evaluated the treatment of comorbid PD and MDD with rTMS(Mantovani et al, 2013).…”
mentioning
confidence: 99%
“…Inclusion criteria, implementation of fNIRS and iTBS application were identical to the procedures described in Deppermann et al (2014) but, for more clarity, will be delineated again in the following sections.…”
Section: Methodsmentioning
confidence: 99%
“…Do to so, we applied a cognitive task as well as an emotional task. Whereas the results of the cognitive task and the corresponding clinical data collected during the first three weeks of iTBS treatment have been published in Deppermann et al (2014) , this manuscript focuses on the results of the emotional paradigm (Emotional Stroop task) and the clinical data which was collected over the whole time course of CBT. More specifically, the following hypotheses were tested: (1) PD/agoraphobia patients are characterised by prefrontal hypoactivation, as assessed by fNIRS, during a task that requires emotion regulation and cognitive control (Emotional Stroop task) compared to controls.…”
Section: Introductionmentioning
confidence: 99%
“…Two studies were conducted using repetitive transcranial magnetic stimulation (rTMS) along with cognitive and additional emotional Stroop tasks, and the results associated with PFC activations/deactivations were compared with those of healthy persons. 155,156 At the baseline (without rTMS), the fNIRS measurements associated with the VFT revealed hypofrontality in the dorsolateral PFC, in panic disorder patients, which signi¯cantly di®ered from the activations observed in healthy persons. However, after sham rTMS, a signi¯cant increase in activation was reported in the left inferior frontal gyrus.…”
Section: Verbal°uency Taskmentioning
confidence: 96%