Does Reproductive Investment Decrease Telomere Length in Menidia menidia?

Gao, Jin; Munch, Stephan B.

doi:10.1371/journal.pone.0125674

Cited by 24 publications

(27 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As telomere length and erosion appear to be adaptive, there is reason to expect they may mediate trade-offs between developmental life-history processes and longevity [64]. Intriguingly, several animal models provide support for this line of thinking [65][66][67][68][69][70]. In addition, then, to early-lifeadversity effects on telomere regulation, the energetically costly process of reproduction can further impact the rate of aging via accelerated telomere erosion, thereby supplying the second hit of our model.…”

Section: Hit Twomentioning

confidence: 72%

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Shalev

Belsky

2016

Medical Hypotheses

View full text Add to dashboard Cite

a b s t r a c tTwo seemingly independent bodies of research suggest a two-hit model of accelerated aging, one highlighting early-life stress and the other reproduction. The first, informed by developmental models of earlylife stress, highlights reduced longevity effects of early adversity on telomere erosion, whereas the second, informed by evolutionary theories of aging, highlights such effects with regard to reproductive cost (in females). The fact that both early-life adversity and reproductive effort are associated with shorter telomeres and increased oxidative stress raises the prospect, consistent with life-history theory, that these two theoretical frameworks currently informing much research are tapping into the same evolutionarydevelopmental process of increased senescence and reduced longevity. Here we propose a mechanistic view of a two-hit model of accelerated aging in human females through (a) early-life adversity and (b) early reproduction, via a process of telomere erosion, while highlighting mediating biological embedding mechanisms that might link these two developmental aging processes.

show abstract

Section: Hit Twomentioning

confidence: 72%

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Shalev

Belsky

2016

Medical Hypotheses

View full text Add to dashboard Cite

show abstract

“…Consequently, if telomeres are biomarkers of reproductive output, the selective pressures acting on them could be sex dependent, which has indeed been shown . Some studies reported significant effects only in one sex, whereas others ignored one sex (males) completely . Discussing sex differences should also attract more attention because in some populations males and females display divergent telomere erosion patterns and losing telomeres may bring about sex‐specific consequences.…”

Section: Studies Published To Date Have Many Limitationsmentioning

confidence: 99%

Does Reproduction Shorten Telomeres? Towards Integrating Individual Quality with Life‐History Strategies in Telomere Biology

Sudyka

2019

BioEssays

View full text Add to dashboard Cite

Reproduction, a basic property of biological life, entails costs for an organism, ultimately detectable as reduction in survival prospects. Telomeres are an excellent candidate biomarker for explaining these reproductive costs, because their shortening correlates with increased mortality risk. For similar reasons, telomeres are perceived as biomarkers of individual "quality." The relationship between reproduction and telomere dynamics is reviewed, emphasizing that cost and quality perspectives, commonly presented in isolation, should be integrated. While a majority of correlative studies have confirmed the relationship between telomere dynamics and various reproductive outputs, only limited experimental support exists showing that reproduction causes telomeres to shorten. A shift of focus to experimental manipulations of reproductive effort/telomere dynamics is crucial. However, the observation of survival reduction in response to these manipulations is essential for establishing telomeres as genuine biomarkers, allowing to unravel trade-offs related to reproduction.

show abstract

“…As a control single-copy gene we used the melanocortin 1 receptor with the primers specific for guppies, MC1R-F (5′-GTCCTCGCTCTCCTTCCTGT-3′) and MC1R-R (5′-CACACCACCGCGATGATGGT-3′). We chose to use MC1R, because it is a single copy gene in many teleost species (Selz et al, 2007) and it has already been used in Menidia menidia for RTL calculation (Gao & Munch, 2015). Furthermore, the mapping of Relative telomere length was obtained following the equation proposed by Pfaffl (Pfaffl, 2001) to 100 ± 20%.…”

Section: Relative Telomere Length Measurementmentioning

confidence: 99%

Maternal predator‐exposure affects offspring size at birth but not telomere length in a live‐bearing fish

Monteforte

Cattelan

Morosinotto

et al. 2020

Ecology and Evolution

View full text Add to dashboard Cite

The perception of predation risk could affect prey phenotype both within and between generations (via parental effects). The response to predation risk could involve modifications in physiology, morphology, and behavior and can ultimately affect long‐term fitness. Among the possible modifications mediated by the exposure to predation risk, telomere length could be a proxy for investigating the response to predation risk both within and between generations, as telomeres can be significantly affected by environmental stress. Maternal exposure to the perception of predation risk can affect a variety of offspring traits but the effect on offspring telomere length has never been experimentally tested. Using a live‐bearing fish, the guppy (Poecilia reticulata), we tested if the perceived risk of predation could affect the telomere length of adult females directly and that of their offspring with a balanced experimental setup that allowed us to control for both maternal and paternal contribution. We exposed female guppies to the perception of predation risk during gestation using a combination of both visual and chemical cues and we then measured female telomere length after the exposure period. Maternal effects mediated by the exposure to predation risk were measured on offspring telomere length and body size at birth. Contrary to our predictions, we did not find a significant effect of predation‐exposure neither on female nor on offspring telomere length, but females exposed to predation risk produced smaller offspring at birth. We discuss the possible explanations for our findings and advocate for further research on telomere dynamics in ectotherms.

show abstract

Does Reproductive Investment Decrease Telomere Length in Menidia menidia?

Cited by 24 publications

References 51 publications

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Early-life stress and reproductive cost: A two-hit developmental model of accelerated aging?

Does Reproduction Shorten Telomeres? Towards Integrating Individual Quality with Life‐History Strategies in Telomere Biology

Maternal predator‐exposure affects offspring size at birth but not telomere length in a live‐bearing fish

Contact Info

Product

Resources

About