1996
DOI: 10.1177/153857449603000303
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Abstract: Progression of atherosclerosis following balloon angioplasty, arterial bypass, or endarterectomy often limits long-term success of revascularization procedures. Therefore, the authors studied the effect of stenosis and relief of stenosis on the development of distal atherosclerosis in a primate model of diet-induced atherosclerosis. Severe stenosis (78 ± 2% diameter reduction) was produced in the midthoracic aorta in 14 cynomolgus monkeys by a constricting band. In 8 monkeys, the stenosis was left in place for… Show more

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“…Some other results showed that following reversal of high-grade mid-thoracic stenosis of the aorta, the distal aorta was no longer protected from the development of the atherosclerosis lesions. 5,13,15 The mechanisms proposed for the protective effects suggest that a proximal arterial occlusion lowers the shearing forces and reduces the insult to the distal arterial wall. 5,12 On the other hand, one of the major problems encountered is impossibility of creation in vivo human model for vessel occlusion investigation due to well-known reasons.…”
Section: Disscusionmentioning
confidence: 99%
“…Some other results showed that following reversal of high-grade mid-thoracic stenosis of the aorta, the distal aorta was no longer protected from the development of the atherosclerosis lesions. 5,13,15 The mechanisms proposed for the protective effects suggest that a proximal arterial occlusion lowers the shearing forces and reduces the insult to the distal arterial wall. 5,12 On the other hand, one of the major problems encountered is impossibility of creation in vivo human model for vessel occlusion investigation due to well-known reasons.…”
Section: Disscusionmentioning
confidence: 99%