Does Relief of Critical Arterial Stenosis Accelerate Distal Atherosclerosis?

Abstract

Progression of atherosclerosis following balloon angioplasty, arterial bypass, or endarterectomy often limits long-term success of revascularization procedures. Therefore, the authors studied the effect of stenosis and relief of stenosis on the development of distal atherosclerosis in a primate model of diet-induced atherosclerosis. Severe stenosis (78 ± 2% diameter reduction) was produced in the midthoracic aorta in 14 cynomolgus monkeys by a constricting band. In 8 monkeys, the stenosis was left in place for three months, after which the distal aorta was revascularized by removal of the constricting band and by balloon angioplasty of the residual stenosis. The results in this group were compared with those in 6 animals whose stenoses were not reversed and with those in 10 Anesthesiology(Abstract continued) animals with no preexisting stenosis. All three groups received an atherogenic diet for three months with no difference in serum cholesterol (836 to 1059 mg/o) during the three-month diet period. Animals with a stenosis had a significant decrease in surface atherosclerosis in the distal aorta (7 ± 6%) compared with control animals (51 + 8%, P < 0.05). This was accompanied by marked reduction in mural cholesterol content (1.5 ± 0.4 mcg/mm2 vs 6.3 ± 1.8 mcg/mm2 in controls, P < 0.05) and a decrease in intimal thickness (0.04 ± 0.02 mm vs 0.07 ± 0.01 mm in controls, P < 0.05). After relief of the stenosis, the percent surface atherosclerosis (58 ± 8%), mural cholesterol (5.4 ± 1.0 mcg/mm2), and intimal thickness (0.09 ± 0.01 mm) were no different from controls. Thus, severe stenosis protects the distal vascular tree from intimal plaque formation, despite marked hypercholesterolemia. Following reversal of a stenosis, distal plaque progression does not occur at an accelerated rate but instead occurs at the same rate as without a preexisting stenosis.

Influence of the chronic abdominal aortic occlusion on the femoral artery disease pattern

“…Some other results showed that following reversal of high-grade mid-thoracic stenosis of the aorta, the distal aorta was no longer protected from the development of the atherosclerosis lesions. 5,13,15 The mechanisms proposed for the protective effects suggest that a proximal arterial occlusion lowers the shearing forces and reduces the insult to the distal arterial wall. 5,12 On the other hand, one of the major problems encountered is impossibility of creation in vivo human model for vessel occlusion investigation due to well-known reasons.…”