Does Reinke’s Edema Grade Determine Premalignant Potential?

Tavaluc, Raluca; Herman, Howard; Lin, Juan; Tan, Melin

doi:10.1177/0003489418796529

Cited by 7 publications

(4 citation statements)

References 19 publications

(32 reference statements)

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“…We had four patients with this condition, with mild dysplasia being diagnosed in only 1 case (3%). For Tavaluc et al, 19 moderate and severe dysplasia associated with Reinke edema correspond to < 17% of cases, and for Lim et al, 20 these rates do not exceed 2%, which is indicative of the low degree of malignancy related to Reinke edema.…”

Section: Discussionmentioning

confidence: 94%

Reinke Edema: Factors that Interfere with Vocal Recovery after Surgery

Neto

Fonseca

Tavares

et al. 2022

Int Arch Otorhinolaryngol

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Introduction Dysphonia and lower pitch after surgery of Reinke edema are common. They are caused especially due to chronic smoking but, probably, other factors should be associated. Objectives To evaluate the results of laryngeal microsurgery in patients with Reinke edema, following a standardized postoperative guidance protocol in our service. Methods Retrospective study. Thirty patients (3 males; 27 females) were included, 70% between 41 and 60 years old. The parameters analyzed in the pre- and postoperative (between 4 and 6 months) of patients undergoing laryngeal microsurgery for Reinke edema were: smoking, vocal symptoms, videolaryngostroboscopy, voice therapy, perceptual and acoustic vocal evaluation, histopathological report. Results Smoking was reported by 100% of the patients and maintained in the postoperative period by 80%. Complete improvement of symptoms in the postoperative period was reported by 43% of them, partial improvement by 40%, and maintenance by 17%.There was low adherence to voice therapy in the pre- and postsurgery.Postoperative videolaryngoscopy indicated congestion (19), atrophy and bowed vocal fold (1), subepithelial edema (2), and normal findings (8). The histological findings were subepithelial edema, enlargement of vessels, inflammation, epithelial hyperplasia, and thickening of the basement membrane. The perceptual and acoustic vocal analyzes indicated improvement of the analyzed parameters. Conclusions The maintenance of some vocal symptoms and laryngeal alterations in videolaryngoscopy after microsurgery of Reinke edema is frequent, even in patients who follow the recommendations of vocal rest and control of gastroesophageal reflux. Vocal symptoms are attributed to changes in the laryngeal mucosa caused by chronic smoking, aggravated by the maintenance of addiction in the postoperative period.

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Section: Discussionmentioning

confidence: 94%

Reinke Edema: Factors that Interfere with Vocal Recovery after Surgery

Neto

Fonseca

Tavares

et al. 2022

Int Arch Otorhinolaryngol

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“…Although exposure to tobacco can affect the development of RE, this study shows that more than just tobacco causes an increase in RE. 15 As shown by a study conducted by Hamdan et al, patients with obstructive sleep disorder (OSA) have higher rates of snoring and higher Epworth Sleepiness Scale scores compared to OSA patients without OSA. 12,16 It appears that women are affected more frequently than men.…”

Section: Discussionmentioning

confidence: 99%

Reinke’s Edema

Irawan,

Wulandari

2023

Advances in Health Sciences Research

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A persistent buildup of fluid in the subepithelial layer of the genuine vocal cord mucosa is known as Reinke's edema . Minimal intervention and superficial excision with edema evacuation and preservation of the medial margin of the vocal fold to enhance voice quality are the two key therapeutic tenets for Reinke's edema. We describe a case of a 65-year-old man who had smoked for 55 years and complained of dysphonia throughout the preceding year, which had become worse within the two weeks prior to admission. The patient additionally said that strenuous exercise or prolonged speech might cause dyspnea to occur. Tonsilalingualis hypertrophy grade 2 was seen during a nasopharyngoscopy, along with bilateral true vocal cord edema. Glottic region thickening and an isodense lesion at C5 level of the glottic area were both seen on the CT scan picture. The patient had vocal cord steroid injections in addition to microlaryngeal surgery. The connective tissue had subepithelial edema, according to histopathological analysis. The patient got postoperative care that included IV ranitidine 50 mg every 12 hours, IV paracetamol 500 mg every 8 hours, IV methylprednisolone 62.5 mg every 12 hours, and oral amlodipine 1 mg twice daily while in the hospital up to one day following surgery. The patient was released, and prescriptions for cefixime 200 mg twice, methylprednisolone 8 mg twice, and sodium diclofenac 50 mg twice were given. The patient was instructed to follow a customized laryngopharyngeal reflux (LPR) diet and to completely rest their voice for one week.

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“…The cover layer of the vocal fold becomes edematous and less stiff due to these changes ( 5 ). Chronic inflammation of the larynx can develop secondary to many conditions, such as smoking, phonotrauma, and gastroesophageal reflux ( 6 ). In the management of RE, smoking cessation, anti-reflux medication, and voice therapy are recommended to help reduce the edema; however, patients whose voice quality does not improve with these therapies need surgery.…”

Section: Introductionmentioning

confidence: 99%

Impact of the Severity of Reinke’s Edema on the Parameters of Voice

Barmak,

Altan,

Yılmaz

et al. 2023

TAO

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Objective: This study aimed to classify the degree of edema in patients with Reinke’s edema (RE) and examine its impact on their voice parameters using both objective and subjective assessment methods. Methods: Objective and subjective voice data of 104 patients diagnosed with RE between 2018 and 2021 were evaluated retrospectively. RE is classified into 4 groups (types 1, 2, 3, and 4). The evaluation included videolaryngostroboscopic examination, acoustic voice analysis, and aerodynamic measurements, GRBAS, Voice Handicap Index-10 (VHI-10), Voice-Related Quality of Life Scale (V-RQOL), and Reflux Septum Index (RSI). Results: Patients with type 1 RE had a significantly lower mean age than those with types 3–4. Although there were no significant differences in acoustic and aerodynamic parameters between the groups, it was observed that F0 and the maximum phonation time decreased as the degree of edema increased. The GRBASTotal, G, and R scores of types 1 and 2 were significantly lower than those of types 3 and 4, as were the scores of type 1 S. There were no statistically significant differences between the RE groups in terms of VHI-10, V-RQOL, and RSI scores. Conclusion: It has been observed that as the severity of RE increases, voice perception and quality (especially types 3 and 4) are negatively affected. Determining the degree of edema will guide the clinician in both the planning of the intervention phase and the follow-up phase.

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Does Reinke’s Edema Grade Determine Premalignant Potential?

Cited by 7 publications

References 19 publications

Reinke Edema: Factors that Interfere with Vocal Recovery after Surgery

Reinke Edema: Factors that Interfere with Vocal Recovery after Surgery

Reinke’s Edema

Impact of the Severity of Reinke’s Edema on the Parameters of Voice

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