Does recognition of depression in primary care affect outcome? The PREDICT-NL study

Kamphuis, Marjolein H.; Stegenga, Bauke T.; Zuithoff, Nicolaas P.A.; King, Michael; Nazareth, Irwin; Wit, Niek J. de; Geerlings, Mirjam I.

doi:10.1093/fampra/cmr049

Cited by 36 publications

(27 citation statements)

References 32 publications

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“…However, we did not detect any effect of these two variables in clinical outcomes at one-month or three-month follow-ups. This is consistent with previous studies with longer follow-up periods (Coyne et al, 1997;Kamphuis et al, 2012;Simon et al, 1999).…”

Section: Treatment Adequacysupporting

confidence: 93%

“…It is not clear whether receiving a valid diagnosis or an adequate treatment allows for a better outcome of common mental disorders (Coyne et al, 1997;Kamphuis et al, 2012;Simon et al, 1999;Tiemens et al, 1996). Our analysis of the impact did not detect an effect of detection or treatment adequacy on the outcome of the disorder at one-month and three-month followups.…”

Section: Impact Of Diagnostic Validity and Treatment Adequacy On The mentioning

confidence: 99%

“…The results of validity studies have been mixed in short-term (Coyne et al, 1997;Tiemens et al, 1996), as well as long-term follow-ups of up to one year (Simon et al, 1999) and 39 months (Kamphuis et al, 2012). Regarding adequacy, the impact of adherence to clinical guidelines is only modest and temporary (Weinmann et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic accuracy and adequacy of treatment of depressive and anxiety disorders: A comparison of primary care and specialized care patients

Castro-Rodríguez

Olariu

Garnier-Lacueva

et al. 2015

Journal of Affective Disorders

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Section: Treatment Adequacysupporting

confidence: 93%

Section: Impact Of Diagnostic Validity and Treatment Adequacy On The mentioning

confidence: 99%

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Diagnostic accuracy and adequacy of treatment of depressive and anxiety disorders: A comparison of primary care and specialized care patients

Castro-Rodríguez

Olariu

Garnier-Lacueva

et al. 2015

Journal of Affective Disorders

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“…None of the subjects was hospitalized. It is fairly well-established that major depression is often not adequately recognized in primary care (Kamphuis et al, 2012). Thus, we accept this as a reasonable explanation of why so few MDD patients were medicated.…”

Section: Discussionmentioning

confidence: 99%

Invisible emotional expressions influence social judgments and pupillary responses of both depressed and non-depressed individuals

et al. 2013

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We used filtered low spatial frequency images of facial emotional expressions (angry, fearful, happy, sad, or neutral faces) that were blended with a high-frequency image of the same face but with a neutral facial expression, so as to obtain a “hybrid” face image that “masked” the subjective perception of its emotional expression. Participants were categorized in three groups of participants: healthy control participants (N = 49), recovered previously depressed (N = 79), and currently depressed individuals (N = 36), All participants were asked to rate how friendly the person in the picture looked. Simultaneously we recorded, by use of an infrared eye-tracker, their pupillary responses. We expected that depressed individuals (either currently or previously depressed) would show a negative bias and therefore rate the negative emotional faces, albeit the emotions being invisible, as more negative (i.e., less friendly) than the healthy controls would. Similarly, we expected that depressed individuals would overreact to the negative emotions and that this would result in greater dilations of the pupil's diameter than those shown by controls for the same emotions. Although we observed the expected pattern of effects of the hidden emotions on both ratings and pupillary changes, both responses did not differ significantly among the three groups of participants. The implications of this finding are discussed.

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“…Reliance on patient reports of psychological symptoms, particularly amongst older patients, may be compromised by stigma related to depression [8]. Consequently it is unsurprising that depression is thought to be under-diagnosed and under-treated amongst older people in Western nations [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of depression amongst outpatients with multimorbidity

Stanners¹,

Barton²,

Shakib³

et al. 2013

Health

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Objectives: Depression may be under-diagnosed and under-treated amongst older adults with multiple chronic illnesses. The current study explores the prevalence of depression diagnosis and Geriatric Depression Scale (GDS) symptoms amongst older multimorbid outpatients, and agreement between GDS scores and doctor-diagnosed depression. Method: Deidentified data from the files of 452 patients aged over 64, with chronic conditions present in two or more organ domains, were extracted from the clinical database of a tertiary referral hospital multidisciplinary outpatient clinic in South Australia between 2005 and 2011. Frequency calculations determined the prevalence of depression diagnosis and GDS categories. Logistic regression, cross-tabulation, kappa and ROC graphs explored relationships between variables. Results: A depression diagnosis had been recorded for 71 (15.7%) patients. Using the recommended cut-off scores for the GDS, 225 (49.8%) patients met criteria for mild-severe depressive symptoms, and 96 (21.3%) met criteria for moderate-severe symptoms. Poor agreement was found between doctor diagnosis of depression and a positive screen for depression using a GDS cut-off score of either 5, k = 0.112 (p = 0.001), or 9, k = 0.189 (p < 0.001), although logistic regression found an association between severity of depression and depression diagnosis, OR = 1.15, p < 0.001 (CI = 1.08 - 1.22). Con-clusion: A much higher proportion of patients with multimorbidities reported threshold level depression symptoms than had a recorded diagnosis of depression, suggesting that although likelihood of diagnosis increases with symptom severity, depression often goes undetected in this population. Depressions’ negative impact on prognosis calls for further investigation of the barriers to screening and diagnosis of depression in multimorbid patients.

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Does recognition of depression in primary care affect outcome? The PREDICT-NL study

Abstract: A minority of patients with MDD is recognized in primary care. Those who were unrecognized had comparable outcome after 12 and 39 months as participants with recognized depression.

Cited by 36 publications

References 32 publications

Diagnostic accuracy and adequacy of treatment of depressive and anxiety disorders: A comparison of primary care and specialized care patients

Diagnostic accuracy and adequacy of treatment of depressive and anxiety disorders: A comparison of primary care and specialized care patients

Invisible emotional expressions influence social judgments and pupillary responses of both depressed and non-depressed individuals

The prevalence of depression amongst outpatients with multimorbidity

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