Does race impact survival for patients with anal squamous cell carcinoma?

Fields, Adam C.; Welten, Vanessa M.; Lu, Pamela; Goldberg, Joel; Irani, Jennifer; Bleday, Ronald

doi:10.1002/jso.25712

Cited by 8 publications

(9 citation statements)

References 25 publications

(68 reference statements)

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“…Another study showed that Black patients have higher annual percentage increases in incidence and mortality of ASCC compared to whites and that 5-year relative survival was significantly lower in Black patients (56% vs. 67%) 39 . Indeed, multiple studies have demonstrated that Black patients with ASCC have higher mortality as compared to whites 14,21,38,40 . In a large cohort, Fields et al found that the Black race was significantly associated with unfavorable survival in stage I, II, and III diseases but not for stage IV disease 40 .…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, multiple studies have demonstrated that Black patients with ASCC have higher mortality as compared to whites 14,21,38,40 . In a large cohort, Fields et al found that the Black race was significantly associated with unfavorable survival in stage I, II, and III diseases but not for stage IV disease 40 . Furthermore, a combined analysis of two studies using the SEER database between 1973 to 2005 and 1988 to 2012 showed the Black race as an independent predictor of worse survival 41,42 .…”

Section: Discussionmentioning

confidence: 99%

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Racial Disparities in Time to Treatment Initiation and Outcomes for Early Stage Anal Squamous Cell Carcinoma

Goksu

Özer

Kazmi

et al. 2020

American Journal of Clinical Oncology

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Objectives: Although cure rates for early stage anal squamous cell cancer (ASCC) are overall high, there may be racial disparities in receipt of treatment and outcome precluding favorable outcomes across all patient demographics. Therefore, we aimed to assess the time to treatment initiation and overall survival (OS) in Black and white patients receiving definitive chemoradiation for early stage ASCC. Methods:We identified patients diagnosed with early-stage (stage I-II) ASCC and treated with chemoradiation diagnosed between 2004-2016 in the National Cancer Database. Clinical and treatment variables were compared by race using chi-square, and OS assessed via Cox regression with 1:1 nearest neighbor propensity score matching.Results: Among 9,331 patients, 90.6% were white. Black patients had longer median time to treatment initiation as compared to white patients (47 vs. 36 days, p<.001), and on multivariable analysis, the Black race was associated with higher odds of > 6 weeks of time to treatment initiation. .08], p<.001). Furthermore, Black patients had worse OS (5-year survival 71% vs. 77%, p<.001), which persisted after propensity score matching (p=.007).Conclusions: Black patients had a longer time to treatment initiation and worse OS as compared to white patients with early-stage ASCC treated with chemoradiation. Further research is needed to better elucidate the etiologies of these disparities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Racial Disparities in Time to Treatment Initiation and Outcomes for Early Stage Anal Squamous Cell Carcinoma

Goksu

Özer

Kazmi

et al. 2020

American Journal of Clinical Oncology

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“…Modifiable and non-modifiable risk factors, including age, genetics, sedentary lifestyle, and socioeconomic status (SES) have been known to affect CRC development (7,(14)(15)(16). Several studies have examined differences in CRC incidence, mortality, and survival by these factors (12,(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). Zhang et al (31) used the Surveillance, Epidemiology, and End Results (SEER) data from 2007 to 2013 to investigate the impact of SES on overall CRC survival.…”

Section: Introductionmentioning

confidence: 99%

A National Study of Colorectal Cancer Survivorship Disparities: A Latent Class Analysis Using SEER (Surveillance, Epidemiology, and End Results) Registries

Ishino

Odame

Villalobos

et al. 2021

Front. Public Health

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Introduction: Long–standing disparities in colorectal cancer (CRC) outcomes and survival between Whites and Blacks have been observed. A person–centered approach using latent class analysis (LCA) is a novel methodology to assess and address CRC health disparities. LCA can overcome statistical challenges from subgroup analyses that would normally impede variable–centered analyses like regression. Aim was to identify risk profiles and differences in malignant CRC survivorship outcomes.Methods: We conducted an LCA on the Surveillance, Epidemiology, and End Results data from 1975 to 2016 for adults ≥18 (N = 525,245). Sociodemographics used were age, sex/gender, marital status, race, and ethnicity (Hispanic/Latinos) and stage at diagnosis. To select the best fitting model, we employed a comparative approach comparing sample-size adjusted BIC and entropy; which indicates a good separation of classes.Results: A four–class solution with an entropy of 0.72 was identified as: lowest survivorship, medium-low, medium-high, and highest survivorship. The lowest survivorship class (26% of sample) with a mean survival rate of 53 months had the highest conditional probabilities of being 76–85 years–old at diagnosis, female, widowed, and non-Hispanic White, with a high likelihood with localized staging. The highest survivorship class (53% of sample) with a mean survival rate of 92 months had the highest likelihood of being married, male with localized staging, and a high likelihood of being non-Hispanic White.Conclusion: The use of a person–centered measure with population-based cancer registries data can help better detect cancer risk subgroups that may otherwise be overlooked.

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“…Additionally, there might be other factors that are more speci c to individual types of gastrointestinal cancers. For example, esophageal adenocarcinoma is more frequent among non-Hispanic whites (NHW); esophageal squamous cell carcinoma and colorectal cancer are more frequent among African Americans and the reasons might be multifactorial, including socioeconomic and lack of health care access, treatment, and prevention [4][5][6][7][8][9]. Also, a lower rate of surgery among Hispanics for esophageal cancer was associated with a decreased survival rate when compared to whites, even when adjusted for relevant socioeconomic and tumor factors [10].…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Cancers: Racial and Ethnicity Differences

Singh

Konduri

Datta

et al. 2021

Preprint

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Objective: The purpose of this study was to examine race and ethnicity for overall survival (OS) and percent survival after 5- and 10-years for patients diagnosed with one of the gastrointestinal (GI) cancers.Method: We used national data for 12 types of GI cancers (esophagus, stomach, gallbladder, intrahepatic bile duct, extrahepatic bile duct, liver, pancreas, small intestine, colon, rectosigmoid, rectum, and anal) for the years 2004-2016. Results: A total of 2,249,213 patients diagnosed with one of the GI tract cancers with median age of 67 years were included in this study. There were 55% male, 77% non-Hispanic White (NHW), 12% were non-Hispanic Black (NHB), 6% were Hispanic, and the rest were classified as ‘Other’ race (4%). OS was higher for the Hispanics, followed by the ‘Other’, NHW and NHB (P <0.001). After adjusting for sex, income, insurance status, grade differentiation, age, and for Charlson-Dayo index, Hispanics and ‘Other’ race category had lower mortality compared to NHW (HR=0.93, 0.92-0.94, p <0.001; HR=0.92, 0.91-0.93, p <0.001), whereas NHB had higher risk compared to NHW (HR=1.09,1.08-1.09 p <0.001). Hispanics had lower mortality than NHW for 11 or 12 types (except esophagus), and ‘Other’ race category had lower risk for 10 of 12 types (except anal and small intestine). Five- and 10-year survival rates were higher for Hispanic patients (47%, 36%) followed by ‘Other’ (42%, 31%), NHW (40%, 28%), and for NHB (38%, 28%).Conclusion: Hispanics and the patients from ‘Other’ race category diagnosed with one of the GI cancers had longer survival probability and lower risk of mortality compared to NHW and NHB.

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Does race impact survival for patients with anal squamous cell carcinoma?

Abstract: Background/Objectives: Racial disparities are known to impact cancer outcomes.

Cited by 8 publications

References 25 publications

Racial Disparities in Time to Treatment Initiation and Outcomes for Early Stage Anal Squamous Cell Carcinoma

Racial Disparities in Time to Treatment Initiation and Outcomes for Early Stage Anal Squamous Cell Carcinoma

A National Study of Colorectal Cancer Survivorship Disparities: A Latent Class Analysis Using SEER (Surveillance, Epidemiology, and End Results) Registries

Gastrointestinal Cancers: Racial and Ethnicity Differences

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