Does proximal genitofemoral nerve division induce testicular maldescent or ascent in the rat?

Abstract

Objective To investigate whether the division of the cryptorchidism was significantly higher in the 90-180-day-old mature rats than in 30-day-old preproximal genitofemoral nerve (GFN) in neonatal rats induces testicular undescent or ascent in adulthood.pubertal rats (P<0.01). The mean (sd) weight of the undescended testes, at 2.36 (0.21) mg/g body weight, Materials and methods Neonatal Wistar King A rats underwent a unilateral proximal GFN transection on was significantly less than that of the contralateral scrotal testes, at 3.83 (0.23) mg/g; P<0.01) and of either the right or left side. At the age of 30 days, testicular descent was examined in all rats and the the control testes at the age of 90-180 days. In the sham-operated rats, all testes were located at the position of the testis recorded. The animals were allowed to develop further and the position of the bottom of the scrotum at 30 days of age and no rats showed any testicular ascent thereafter. testis re-examined at the age of 90-180 days, when the testes were removed and weighed. Sham-operatedConclusions The proximal division of the GFN in neonatal rats not only causes inguinoscrotal testicular malrats were used as controls.Results At the age of 30 days, four of the 46 (9%) descent but may also induce testicular ascent in adulthood. Testicular ascent may thus be caused by some operated rats showed a unilateral undescended testis on the operated side. At the age of 90-180 days, 43 intrauterine disorders of the GFN in patients with ascending testis. rats were re-examined (three rats died before re-examination); 34 (79%) of these rats showed undeKeywords Ascending testis, genitofemoral nerve, rat scended testes on the operated side. The occurrence of induced cryptorchidism, although Clarnette et al. [11] Introduction and Han and Choi [12] reported that accurate division of the GFN did not cause undescended testes. In the Several authors have described ascending testes as a new variant of cryptorchidism in which the testis once present study, we investigated whether division of the proximal GFN in neonatal rats induced testicular ascent descends into the scrotum in early infancy and then later spontaneously ascends out of the scrotum [1][2][3][4][5][6][7][8].in adulthood. However, the mechanism involved in spontaneous testicular ascent is still not completely understood. Some Materials and methods authors have postulated that the absorption of the processus vaginalis would retract the testis [2], whileWistar King A newborn rats, used within 72 h after birth, were obtained from a colony maintained at Kyushu other authors suggested that a failure of the natural elongation of the spermatic cord may cause spontaneous University and anaesthetized with ether. Forty-six rats underwent a laparotomy through a small transverse ascending testes [1].On the other hand, the genitofemoral nerve (GFN) has lower abdominal incision just below the umbilicus. The GFN was transected proximally by dividing the nerve on been proposed to play an important role in inguinoscrotal ...

Factors controlling testis descent

“…Prenatal administration of an anti-androgen inhibits development of the genitofemoral nerve nucleus in the rat and testis maldescent (43). If the genitofemoral nerve is transected, this leads to a failure of gubernacular migration and normal testis descent (44). Evidence for the role of this nerve and its CGRP transmitter in testis descent in humans is less persuasive than in rodents.…”

Intrascrotal Extratesticular Neurofibroma as a Possible Cause of Failed Descent in Ipsilateral Testis

“…The sensory branch of genitofemoral nerve releases calcitonin gene related peptide to influence the migration of gubernaculum and testicular descent [10]. This effect of genitofemoral nerve constitute the inguinal phase of testicular descent and can be impaired if GFN is divided [11]. In the present patient, undescended testis associating an IEN suggests that neurofibromas originating from GFN may also cause undescended testis by hampering the inguinal phase of testicular descent.…”

Short-time exposure to vinclozolin in utero induces testicular maldescent associated with a spinal nucleus alteration of the genitofemoral nerve in rats

“…[8][9][10][11][12][13][14] The proximal division of the GFN in neonatal rats has been known to prevent normal testicular descent. 9,10 The spinal nucleus of the GFN is located L1-L2 in the spinal cord and is sexually dimorphic in rodents. 8 14 showed androgen receptor in the fetal rat spinal cord on gestational day 15, a day before the start of androgenic action for testicular descent.…”