Does protein expression predict recurrence of benign World Health Organization grade I meningioma?

Kärjä, Vesa; Sandell, Pär-Johan; Kauppinen, Tarja; Alafuzoff, Irina

doi:10.1016/j.humpath.2009.06.020

Cited by 17 publications

(33 citation statements)

References 33 publications

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“…Such diminished expression was also associated with recurrent tumours. This phenomenon may be related to phenotypical changes during tumour progression or malignant transformation reminiscent of EMT described in epithelial tumour cells, which show loss of E‐cadherin and claudins due to induction of EMT‐related transcription factors 11,12 . In line with this, our studies also show activation of twist in atypical or malignant meningiomas, indicating that such a transformation occurs at the level of transcriptional factors.…”

Section: Inverse Association Between Claudin 11 and Twist In Meningisupporting

confidence: 85%

“…This phenomenon may be related to phenotypical changes during tumour progression or malignant transformation reminiscent of EMT described in epithelial tumour cells, which show loss of E-cadherin and claudins due to induction of EMT-related transcription factors. 11,12 In line with this, our studies also show activation of twist in atypical or malignant meningiomas, indicating that such a transformation occurs at the level of transcriptional factors. Loss of claudin 11 and up-regulation of twist can thus be considered to be putative indicators of recurrence and more aggressive behaviour of meningiomas.…”

supporting

confidence: 88%

“…In this study we investigated the expression of claudin 1 and claudin 11 in a set of 103 meningiomas, of which 44 were primary and the rest recurrent. The material originated from the archives of the Department of Pathology, Kuopio University Hospital during 1982–2002 and has been characterized previously 11 . The study was approved by the ethical committee of the Kuopio University Hospital district.…”

Section: Inverse Association Between Claudin 11 and Twist In Meningimentioning

confidence: 99%

“…The material originated from the archives of the Department of Pathology, Kuopio University Hospital during 1982-2002 and has been characterized previously. 11 The study was approved by the ethical committee of the Kuopio University Hospital district. The material had been fixed in 10% buffered formalin and embedded in paraffin.…”

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confidence: 99%

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Claudins 1, 11 and twist in meningiomas

et al. 2010

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Section: Inverse Association Between Claudin 11 and Twist In Meningisupporting

confidence: 85%

supporting

confidence: 88%

Section: Inverse Association Between Claudin 11 and Twist In Meningimentioning

confidence: 99%

mentioning

confidence: 99%

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Claudins 1, 11 and twist in meningiomas

et al. 2010

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“…During our quest for an intraoperative quantitative method to predict the risk of recurrence, we noted intratumoral heterogeneity in the proliferative potential of meningioma cells. Some previous studies failed to prove the predictive value of MIB‐1 LI, which may be partially explained by its low quantitative capability and heterogeneity. Thus, iFC may be effective in precisely measuring the proliferative ability in each case, which we believe leads to a more accurate estimation of tumor behavior after surgery.…”

Section: Discussionmentioning

confidence: 96%

Intraoperative quantification of meningioma cell proliferation potential using rapid flow cytometry reveals intratumoral heterogeneity

et al. 2019

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Background Standard sampling methods to evaluate the proliferative ability of meningioma have not been established. Methods This prospective study was conducted to evaluate the effectiveness of intraoperative rapid flow cytometry (iFC) using raw samples for the quantitative assessment of proliferative ability in meningioma cells and to investigate intratumoral heterogeneity. Proliferation index (PI) was defined as the ratio of aneuploid cells with an abnormal number of chromosomes to the total cells. Results From 50 patients, 118 specimens were analyzed. There was a statistically significant correlation between the postoperative MIB‐1 labeling index (LI) and PI (R = 0.59, P < 0.0001). A higher PI was correlated with a higher annual growth rate (AGR, cm3/y) (R = 0.50, P = 0.0002, 26 patients). AGR showed a correlation with the intratumoral distribution of PI. PI was the highest at the center or the peripheral section of the tumor in tumors with high AGR, whereas it was highest at the dural attachment in tumors with low AGR (P = 0.039, n = 20). Pial feeders were more frequently observed when PI was high in the center or in the peripheral section (P = 0.006, n = 37). Conclusions Rapid iFC may thus become a substitute for MIB‐1 LI. Intratumoral heterogeneity of cellular proliferative potential exists in meningiomas and is related to tumor biological characteristics such as AGR and development of pial feeders. This observation underscores the importance of standardization in the sampling method to accurately estimate the risk of meningioma recurrence.

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Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas

et al. 2010

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Prediction of recurrence remains a challenge in histopathological benign/grade I tumors. Osteopontin (OPN) plays important roles in tumorigenesis, invasion, and metastasis of several human cancers. In this study, we investigated OPN protein expression by evaluating the differences between recurrent and non-recurrent histologically benign meningiomas. Thirty-two patients were enrolled, and 23 benign non-recurrent meningiomas and 9 benign recurrent meningiomas were followed for a mean of 34 months after complete surgical resection (Simpson grades I and II). Cytoplasmic OPN staining was evaluated by means of immunohistochemistry (IHC) score and by use of the Allred-8-unit system. We examined clinical biological data, their relationship with tumor recurrence, and the expression of OPN. Our results showed that meningioma recurrence correlated significantly with OPN IHC score (P = 0.001). An OPN Allred score between 0 and 3 was associated with a recurrence-free time of more than 25 months. In comparison, an OPN Allred score from 4 to 8 was indicative of a shorter average recurrence-free time. We concluded that OPN IHC score may play a role in prediction of the recurrence of the grade I meningiomas. Moreover, determination of the OPN Allred score is a reliable, quantitative tool for predicting recurrence-free time in benign meningioma patients.

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Does protein expression predict recurrence of benign World Health Organization grade I meningioma?

Cited by 17 publications

References 33 publications

Claudins 1, 11 and twist in meningiomas

Claudins 1, 11 and twist in meningiomas

Intraoperative quantification of meningioma cell proliferation potential using rapid flow cytometry reveals intratumoral heterogeneity

Osteopontin expression is a valuable marker for prediction of short-term recurrence in WHO grade I benign meningiomas

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