Does prostate size predict the urodynamic characteristics and clinical outcomes in benign prostate hyperplasia?

Singh, Kuldeep; Sinha, Rahul Janak; Sokhal, Ashok Kumar; Singh, Vishwajeet

doi:10.4103/0974-7796.210029

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…In this study, the values of PSAD of Sri Lankan men were fluctuating around 0.11(mean PSAD) in different age groups and it did not show a gradual linear increase with ageing. A study done in healthy Iranian men confirmed that PSAD was agedependent [8,9] and this is not comparable with the results of this study.…”

Section: Figure 1 Variations Of Mean Prostate Volume With Different A...contrasting

confidence: 98%

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Balagobi¹,

JP²,

Chandrasekera³

et al. 2022

GSC Adv. Res. Rev.

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Purpose: Benign Prostatic Hyperplasia (BPH) is an important cause of morbidity for ageing men worldwide. However, the available study is limited on the natural history of BPH and dynamics of Prostate-Specific Antigen (PSA) in Sri Lankan population. This study aimed to assess the relationship between serums Prostate Specific Antigen (PSA), prostate volume (PV), and PSA density (PSAD) and to evaluate variations of above parameters with aging and to assess the mean prostate volume of Sri Lankan men with Benign Prostatic Hyperplasia (BPH). Material and methods: This was a retrospective study, men diagnosed with Benign Prostatic Hyperplasia from January 2009 was evaluated. This study was approved by the Ethics Review Committee of Colombo South Teaching Hospital and the patient informed written consent was received. Those with UTI, PSA >10ng/dl and suspicious prostate in digital rectal examination (DRE) were excluded from the study. Data were statistically analyzed to determine the relationship of PSA, PV, PSAD and variations with age groups. Results: This study recruited a total number of 562 men, clustered into 5 age groups and their mean Prostate Volume (PV) was 42.9 (12.56SD). The median PSA was 2.5ng/dl with an inter quartile range of 0.37. The mean PSA density (PSA/PV) was 0.11 (0.023SD). The tendency towards increase in PSA and prostate volume with increasing age showed statistical significance (P<0.05). PSA density was not changed much between different age group except 51-60 age group. It is noted PSAD was fluctuating around mean PSAD of 0.11 in majority of the age groups. Conclusion: PV and PSA increase with age. Mean PV is relatively small compare to blacks and Caucasians. .PSA density in Sri Lankan men is comparable to published data in other countries and could be used as a surrogate marker to evaluate the prostate and for therapeutic decision making.

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Section: Figure 1 Variations Of Mean Prostate Volume With Different A...contrasting

confidence: 98%

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Balagobi¹,

JP²,

Chandrasekera³

et al. 2022

GSC Adv. Res. Rev.

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“…However, multiple studies have found that the PV in patients with BPH is not a valid predictor of the diagnosis of BOO or surgical efficacy. 32 33 In this study, we observed no significant differences in postoperative indicators between patients with large and small PVs. In general, the larger the PV volume, the more likely BOO will occur.…”

Section: Discussioncontrasting

confidence: 54%

The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia: a retrospective, single-center study

Liu

et al. 2023

Asian Journal of Andrology

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We investigated the impact and predictive value of bladder function in patients with benign prostatic hyperplasia (BPH) on the efficacy of transurethral prostatectomy. Symptomatic, imaging, and urodynamic data of patients who underwent transurethral prostatectomy at West China Hospital of Sichuan University (Chengdu, China) from July 2019 to December 2021 were collected. Follow-up data included the quality of life (QoL), International Prostate Symptom Score (IPSS), and IPSS storage and voiding (IPSS-s and IPSS-v). Moreover, urinary creatinine (Cr), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and prostaglandin estradiol (PGE2) were measured in 30 patients with BPH and 30 healthy participants. Perioperative indicators were determined by subgroup analyses and receiver operating characteristic (ROC) curve analysis. Among the 313 patients with BPH included, patients with severe micturition problems had more improvements but higher micturition grades postoperatively than those with moderate symptoms. Similarly, good bladder sensation, compliance, and detrusor contractility (DC) were predictors of low postoperative IPSS and QoL. The urinary concentrations of BDNF/Cr, NGF/Cr, and PGE2/Cr in patients were significantly higher than those in healthy participants (all P < 0.001). After evaluation, only DC was significantly related to both urinary indicators and postoperative recovery of patients. Patients with good DC, as predicted by urinary indicators, had lower IPSS and IPSS-v than those with reduced DC at the 1st month postoperatively (both P < 0.05). In summary, patients with impaired bladder function had poor recovery. The combined levels of urinary BDNF/Cr, NGF/Cr, and PGE2/Cr in patients with BPH may be valid predictors of preoperative bladder function and postoperative recovery.

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“…In total, 324 patients with BOO and a prostate volume of <30 mL as measured by transrectal ultrasonography were analyzed 3,7. All patients had LUTS, and conservative treatments (doxazosin 4mg/tamsulosin 0.2 mg once daily ± finasteride 5 mg once daily for 12 weeks) had been ineffective 8–10.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, the patients were divided into a TURP group and PKEP group according to the surgical procedure performed, and the difference in each of the above parameters between the two groups was compared. The inclusion criteria of this study should be all included the following:8,13–15 ①prostate volume of ≤30 mL as measured by transrectal ultrasonography;3,7 ②Qmax of ≤15 mL or acute urinary retention or preoperative residual urine volume of ≥100 mL or presence of LUTS caused by benign prostatic obstruction;16–19 ③IPSS of >19 points; ④Preoperative cystoscopy to examine benign prostatic obstruction (BPO) and bladder trabeculation. ⑤An interest and ability to participate in this study.…”

Section: Methodsmentioning

confidence: 99%

<p>Predictors Of Postoperative Lower Urinary Tract Symptoms Improvements In Patient With Small-Volume Prostate And Bladder Outlet Obstruction</p>

et al. 2019

TCRM

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ObjectiveTo explore the factors associated with improvement of lower urinary tract symptoms (LUTS) after transurethral plasmakinetic enucleation of the prostate (PKEP) and transurethral resection of the prostate (TURP) in patients with a small-volume prostate and bladder outlet obstruction (BOO).MethodsThe clinicopathologic data of 257 patients with BOO and a small-volume prostate from January 2013 to January 2018 were retrospectively collected preoperatively, 3 months postoperatively, and 12 months postoperatively. Patients were divided into postoperative success and failure groups based on the IPSS, IPSS-v, and IPSS-s. The relationship between each parameter and the improvement of postoperative LUTS was analyzed. Subgroup analysis was performed to compare the differences between the TURP and PKEP groups.ResultsAmong patients followed up for 3 months postoperatively, multivariate analysis demonstrated that IPP, PUA, and post-PCB were significant predictors of postoperative IPSS improvement; TZI, IPP, and PUA were significant predictors of postoperative IPSS-v improvement; post-PCB and the surgical procedure were significant predictors of IPSS-s improvement; and IPP and PUA were significant predictors of postoperative Qmax improvement. Among patients followed up for 12 months postoperatively, multivariate analysis revealed that IPP, PUA, and post-PCB were significant predictors of postoperative IPSS improvement; PUA was a significant predictor of postoperative IPSS-v improvement; post-PCB was a significant predictor of IPSS-s improvement; and IPP and PUA were significant predictors of postoperative Qmax improvement. The post-PCB was significantly lower in the PKEP than the TURP group and the prostatic calculi removal rate was significantly higher in the PKEP than the TURP group.ConclusionPatients with a greater preoperative IPP and PUA and smaller post-PCB showed greater improvement of postoperative LUTS. PKEP might help to remove calculi from between the transitional and peripheral zones of prostate. Compared with conventional TURP, PKEP may improve the early postoperative storage symptoms of LUTS in patients with a small-volume prostate and BOO.

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Does prostate size predict the urodynamic characteristics and clinical outcomes in benign prostate hyperplasia?

Cited by 7 publications

References 20 publications

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

Relationship of prostate volume and prostate-specific antigen levels in Sri Lankan men with Benign Prostatic Hyperplasia

The effect of bladder function on the efficacy of transurethral prostatectomy in patients with benign prostatic hyperplasia: a retrospective, single-center study

<p>Predictors Of Postoperative Lower Urinary Tract Symptoms Improvements In Patient With Small-Volume Prostate And Bladder Outlet Obstruction</p>

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