Does Probiotic Consumption Enhance Wound Healing? A Systematic Review

Abstract

The use of probiotics is one of the emerging lines of treatment for wound healing. This systematic review aimed to summarize currently available evidence on the effect of oral or enteral probiotic therapy on skin or oral mucosal wound healing in humans. To verify the developments in this field and the level of available scientific evidence, we applied a broad search strategy with no restrictions on wound type, target population, probiotic strain, or intervention protocol used. This review included seven studies involving 348 individuals. Four studies reported positive outcomes for healing improvement after probiotic therapy, and none of the studies reported adverse effects or a marked increase in wound healing time. The positive or neutral results observed do not generate strong evidence regarding the effectiveness of probiotics for wound healing. However, they suggest a promising field for future clinical research where the probiotic strains used, type of wounds, and target population are controlled for.

Metal-phenolic self-assembly shielded probiotics in hydrogel reinforced wound healing with antibiotic treatment

“…Therefore, using probiotics alone for wound treatment might not achieve a satisfactory therapeutic effect. 45 The same result was also reflected in the appearance and analysis of the tissue in HE staining. In addition, more hair follicles and thicker neo-granulation tissue were observed in the Gel/L@FeTA group both at 6 days and 12 days (Fig.…”

“…Therefore, using probiotics alone for wound treatment might not achieve a satisfactory therapeutic effect. 45…”

Probiotics and postbiotics play a role in maintaining dermal health

“…The authors suggest that probiotics may have potential as an adjunct therapy for improving wound healing outcomes. 106…”

“…The authors suggest that probiotics may have potential as an adjunct therapy for improving wound healing outcomes. 106 While there is limited research on the potential negative effects of probiotics and postbiotics on viral infections in wound healing, some studies suggest that they may have potential drawbacks for enhancing immune function and reducing viral replication.…”

Culture-Delivery Live Probiotics Dressing for Accelerated Infected Wound Healing

“…An emerging treatment line for infected skin wounds is the use of probiotics, defined by the Food and Agriculture Organization of the United Nations (FAO) and the World Trade Organization (WTO) as “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host.” Probiotic therapy, a promising therapeutic approach, has health-promoting effects in solving life-threatening problems, such as preventing cutaneous inflammatory conditions, diabetes, respiratory tract infections, , various gastrointestinal (GI) disorders, − urogenital infections, cancer, , etc. The mechanisms of probiotics’ action against pathogens have been proposed, including the production of antimicrobials and bacteriocins, cytokine production, and activating antimicrobial immune responses, resulting in moderating microbial dysbiosis and regulating the immune system. , Lactobacillus reuteri (L.…”