Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis

Treister-Goltzman, Yulia; Friger, Michael; Peleg, Roni

doi:10.1007/s00198-018-4635-1

Cited by 10 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individuals homozygous for CC alleles in the lactase gene are not able to digest lactose, and tend therefore to consume less milk as compared with lactase persistent subjects, because of symptoms of lactose intolerance like flatulence, abdominal pain and diarrhea, resulting from the fermentation of undigested lactose in the large intestine. A meta-analysis comparing lactose absorbers to lactase-deficient subjects, as determined by genetic testing or breath hydrogen test, in five case–control studies, has not found a difference in areal BMD [ 66 ]. However, when expressed in Z score, i.e., age-adjusted, lumbar spine and total hip displayed lower BMD values in lactase-deficient subjects.…”

Section: Tolerance To Dairy Products and Safetymentioning

confidence: 99%

Dairy products and bone health

Rizzoli

2021

Aging Clin Exp Res

View full text Add to dashboard Cite

Bone mineral mass, geometry and microstructure, hence determinants of fracture risk, result bone accrual during growth and bone loss later in life. Peak bone mass, which is reached by the end of the second decade of life, is mainly determined by genetic factors. Among other factors influencing bone capital, dietary intakes, particularly calcium and protein, play a significant role in peak bone mass attainment. Both nutrients are provided in dairy products, which accounts for 50–60% and 20–30% of the daily calcium and protein intakes, respectively. Children avoiding dairy products are at higher risk of fracture, as are adults or older individuals following a diet devoid of dairy products, like vegans. Various intervention trials have shown some beneficial effects of dairy products on bone capital accumulation during growth and on bone turnover in adults. In observational studies, dairy products intake, particularly the fermented ones, which also provide probiotics in addition to calcium, phosphorus and protein, appear to be associated with a lower risk of hip fracture.

show abstract

Section: Tolerance To Dairy Products and Safetymentioning

confidence: 99%

Dairy products and bone health

Rizzoli

2021

Aging Clin Exp Res

View full text Add to dashboard Cite

show abstract

“…A meta‐analysis of 18 randomized controlled trials revealed that lactose‐intolerant patients had significantly lower BMD in their hip joints compared to lactose‐tolerant individuals. This is likely due to reduced levels of plasma calcium, vitamin D, and PTH (Treister‐Goltzman et al., 2018).…”

Section: Dairy Products For the Prevention And Control Of Osteoporosismentioning

confidence: 99%

New insights into dairy management and the prevention and treatment of osteoporosis: The shift from single nutrient to dairy matrix effects—A review

Wang,

Zhao,

Yang

et al. 2024

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Dairy is recognized as a good source of calcium, which is important for preventing osteoporosis. However, the relationship between milk and bone health is more complex than just calcium supplementation. It is unwise to focus solely on observing the effects of a single nutrient. Lactose, proteins, and vitamins in milk, as well as fatty acids, oligosaccharides, and exosomes, all work together with calcium to enhance its bioavailability and utilization efficiency through various mechanisms. We evaluate the roles of dairy nutrients and active ingredients in maintaining bone homeostasis from the perspective of the dairy matrix effects. Special attention is given to threshold effects, synergistic effects, and associations with the gut–bone axis. We also summarize the associations between probiotic/prebiotic milk, low‐fat/high‐fat milk, lactose‐free milk, and fortified milk with a reduced risk of osteoporosis and discuss the potential benefits and controversies of these dairy products. Moreover, we examine the role of dairy products in increasing peak bone mass during adolescence and reducing bone loss in old age. It provides a theoretical reference for the use of dairy products in the accurate prevention and management of osteoporosis and related chronic diseases and offers personalized dietary recommendations for bone health in different populations.

show abstract

“…By this valuable article, we may further speculate that the ones with isolated lactase deficiency have the tendency to be diagnosed with osteoporosis, since the studies, the ones that were included into this meta-analyses, consisted of not only the lactose intolerant patients, but also the ones with isolated lactase deficiency [1].…”

mentioning

confidence: 98%

“…To the Editor, I have read Treister-Goltzman Y's article with a great interest since I have been working on the answer whether physicians have to treat the patients with isolated lactase enzyme deficiency [1]. By isolated lactase enzyme deficiency, I would rather refer to the patients with lactase deficiency determined by objective diagnostic tools, e.g., genetic analyses, direct enzyme activity measurement through intestinal biopsy or H 2 breath test, whereas presenting no lactose intolerance related symptoms [2,3].…”

mentioning

confidence: 99%