Does Presoaking Synthetic Mesh in Antibiotic Solution Reduce Mesh Infections? An Experimental Study

Abstract

Presoaking multifilament and composite mesh in vancomycin solution reduces MRSA bacterial growth. Its implementation may reduce the risk of mesh infection in clean-contaminated cases, although further investigation with human trials should be performed.

Gentamicin for prevention of intraoperative mesh contamination: demonstration of high bactericide effect (in vitro) and low systemic bioavailability (in vivo)

“…In the literature there is some support for this assumption. Presoaking multifilament and composite hernia meshes with vancomycin (10 mg/ml) before implantation in an animal model improves bacterial (MRSA) clearing significantly (Parietex PCO: 0 vs. 56 %, p \ 0.006), after 30 days of implantation [33]. In monofilament textile meshes this effect is markedly lower, as shown also in the present study.…”

Ventral hernia: Patient selection, treatment, and management

“…Furthermore, coating synthetic mesh or biologic matrix with antimicrobial agents may further enhance its bacteria-resisting ability. 116,117 In the face of high bacterial load (i.e inoculated with 10 9 bacteria), neither mesh is able to clear infection. 115 When choosing synthetic mesh, one must choose between low-density and mid-density mesh.…”

Innovative Modifications for Preventing Mesh Infections

“…In a recent prospective randomized study by Yabanoğlu et al, investigating the effect of soaking the mesh in vancomycin before implantation on wound infection rates in ventral hernia repair, there was no difference between pre-soaking the mesh in vancomycin and saline. It has been observed that the release and degradation rates of the antimicrobial, the concentration in the wound are difficult to assess and reproduce with pre-soaking technique [76][77][78][79][80][81].…”