Does Preoperative Serum Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Lymphocyte to Monocyte Ratio (LMR) Predict Prognosis Following Radical Surgery for Pancreatic Adenocarcinomas? Results of a Retrospective Study

Gupta, Vikas; Chaudhari, Vikram; Shrikhande, Shailesh V.; Bhandare, Manish

doi:10.1007/s12029-021-00683-1

Cited by 3 publications

(3 citation statements)

References 34 publications

(44 reference statements)

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“…It enabled us to compute a threshold based on diseases’ progress and be different from the results obtained by benign disease patients as the control cohort. The obtained cut-offs for CEA, CA153, CA125, killer T cell, and LMR are slightly higher for those found in previous studies (CEA: 5 ng/ml, CA153: 31.3 U/ml, B cell%: literature range: 7%–23%, Th/Tc: literature range: 0.9-3.6, LMR: literature range: 3-5.5) ( 20 , 30 – 32 , 37 – 39 ). ROC analysis showed that the accuracy of a single marker for diagnosis of stage I-III BC patients and stage IV BC patients was not high (AUC <0.800).…”

Section: Discussioncontrasting

confidence: 52%

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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PurposeThis study aims to clarify the prognostic significance of metastasis-related indicators in peripheral blood in stage I-III breast cancer (BC).MethodsThe clinicopathological data of 938 breast cancer patients and 509 benign breast disease patients were retrospectively analyzed, and fasting blood samples were collected before treatment. Univariate and multivariate regression analyses were used to evaluate factors related to metastasis risk and prognosis. The Kaplan-Meier method was used to generate survival curves, and the log-rank test was used to measure differences in survival between groups.ResultsUse the cut-off value (3.433) of LMR, the logistic regression analysis revealed that high carbohydrate antigen 153 (CA153), carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), killer T cell level, and low lymphocyte to monocyte ratio (LMR) level were significantly associated with BC distant metastasis. In contrast, LMR>=3.433 (HR: 0.409, 95%CI: 0.193–0.867, P = 0.020), Th/Tc ratio >=1.946 (HR: 0.378, 95% CI: 0.158–0.904, P =0.029) is regarded as a protective factor in the multivariate cox analyses. LMR is an independent prognostic factor for DFS in HER2-negative BC patients.ConclusionPeripheral blood parameters play an important role in predicting distant metastasis and prognosis of BC patients. As a potential marker, LMR can predict the metastasis and prognosis of patients with stage I-III BC.

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Section: Discussioncontrasting

confidence: 52%

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

et al. 2022

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“…10,11 A host of hematological inflammatory biomarkers, including the albumin (Alb) level, neutrophil, lymphocyte, and monocyte counts, neutrophil-tolymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are predictive markers in cancer patients. [12][13][14][15][16][17][18] Tests for these biomarkers are available in routine clinical practice and help clinicians evaluate the clinical outcomes and survival of cancer patients. A new marker, called the systemic inflammation score (SIS), which is based on the Alb level and LMR, has been proposed.…”

Section: Introductionmentioning

confidence: 99%

The Systemic Inflammation Score is Associated with the Survival of Patients with Prostate Cancer

Xie¹,

Xu²,

Zhao³

et al. 2023

JIR

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Background:The systemic inflammation score (SIS) based on the albumin (Alb) level and lymphocyte-to-monocyte ratio (LMR), has been associated with survival in some cancers. However, its prognostic role in prostate cancer (PCa) remains unclear. Methods: The associations between the SIS and the clinicopathological features of PCa were evaluated. The correlations between the SIS and overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier analysis and the Log rank test. Univariate and multivariate Cox analyses were conducted to determine the prognostic factors for PCa. Hazard ratios and 95% confidence intervals were calculated. Results: A total of 253 patients with PCa were included in this study. The Kaplan-Meier analysis and Log rank test suggested that patients with a higher Alb level, higher LMR, or a lower SIS had better 5-year OS and PFS compared with patients with a lower Alb level or lower LMR or higher SIS. Univariate and multivariate Cox analyses showed that drinking, prostate-specific antigen level >100 ng/mL, and neutrophil-to-lymphocyte ratio >2.09 were significant prognostic factors for OS and PFS in patients with PCa. Nomograms for 5-year OS and PFS were established with concordance index values of 0.888 and 0.824, respectively. The calibration curve was consistent between the actual observations and the prediction nomogram for OS and PFS probability at 5 years. Conclusion:A high SIS is associated with unfavorable survival in patients with PCa. The SIS serves as a novel independent prognostic factor for OS in patients with PCa.

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“…More and more studies have pointed out that inflammatory markers based on hematology, such as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and OPNI, have important clinical significance. They can indicate the prognosis of patients with various tumors [9][10][11][12][13][14], such as pancreatic cancer, cervical cancer, thyroid cancer, gastric cancer, lung cancer, and esophageal cancer. Of course, it also includes HCC [15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of OPNI in Hepatocellular Carcinoma

Zhou

Yang

2023

Oncology

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Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. The overall prognosis of patients with HCC is not very ideal. Early detection of HCC has become one of the important means to reduce mortality. More and more studies have pointed out that inflammatory markers based on hematology, such as Onodera’s prognostic nutritional index (OPNI), have important clinical significance. However, there is a lack of relevant research on the diagnosis of HCC by inflammatory markers. Methods: We retrospectively enrolled 633 patients and prospectively recruited 121 consecutive patients, to explore the correlation between inflammatory markers and diagnosis of HCC. Based on the prognostic indicators, different diagnostic models were constructed and the diagnostic performance of different models was further compared. Results: The best cutoff value of OPNI in the diagnosis of HCC is 43.925. Area under the receiver operating characteristics curve (AUC) of gender + age + AFP + OPNI diagnosis of HCC is 0.837 (95% CI: 0.702–0.868) in the retrospective cohort. Compared with gender + age + AFP, the Nagelkerke R2 of gender + age + AFP + OPNI increased from 0.234 to 0.426, and AUC increased by 0.0973 (95% CI: 0.0659–0.1290). DeLong test, net reclassification improvement (NRI) test, and integrated discrimination improvement (IDI) test are all statistically significant. In the prospective cohort, AUC of gender + age + AFP + OPNI diagnosis of HCC is 0.782 (95% CI: 0.696–0.869). Compared with gender + age + AFP, NRI test is statistically significant (categorical 0.0909 [95% CI: 0.0060–0.1759], p = 0.0359). Conclusion: In the process of monitoring the occurrence of HCC in patients with risk factors, OPNI can be included as appropriate to improve the accuracy of HCC diagnosis.

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Does Preoperative Serum Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Lymphocyte to Monocyte Ratio (LMR) Predict Prognosis Following Radical Surgery for Pancreatic Adenocarcinomas? Results of a Retrospective Study

Cited by 3 publications

References 34 publications

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

Prognostic Evaluation of Metastasis-Related Lymphocyte/Monocyte Ratio in Stage Ⅰ-Ⅲ Breast Cancer Receiving Chemotherapy

The Systemic Inflammation Score is Associated with the Survival of Patients with Prostate Cancer

Diagnostic Value of OPNI in Hepatocellular Carcinoma

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