Does preoperative platelet-lymphocyte ratio or prognostic nutritional index predict survival after surgical resection for hepatocellular carcinoma?

Kabir, Tousif; Noor, N.A. Mohd; Junnarkar, Sameer P; Low, Jee Keem; Woon, Winston; Shelat, Vishal G

doi:10.1016/j.hpb.2016.01.128

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no evident association between the PLR and OS was found in the study conducted by Kabir et al . in Singapore ( p = 0.341) [ 21 ], and a similar result was detected in Peng et al . study in China ( p = 0.856) [ 44 ], however, they were both excluded from the meta-analysis because they only reported the relevant p values without HR.…”

Section: Discussionsupporting

confidence: 81%

“…[ 49 ] and Kabir et al . [ 21 ] both covered that PLR was not evidently associated with the RFS of HCC. However, Ji et al .…”

Section: Discussionmentioning

confidence: 99%

“…However, no evident association between the PLR and OS in HCC was distinguished in the study conducted by Kabir et al . [ 21 ]. Therefore, controversy does exist on the prognostic role of PLR in HCC.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Zhao

Zhu

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Background and AimsSeveral studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC.ResultsA total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5. The results indicated that high PLR was significantly associated with a worse OS when compared to the low PLR (HR = 1.60, 95% CI = 1.23−2.08, p = 0.0005; I2 = 88%, p < 0.00001). Similar results were detected in the subgroup analysis of the analysis model, cut-off value, ethnicity, sample size and therapy. However, no obvious correlation between the PLR and DFS/RFS in patients with HCC was observed (HR = 1.21, 95% CI = 0.87−1.67, p = 0.26; I2 = 61%, p = 0.07).Materials and MethodsA complete literature search in the PubMed, Cochrane Library and Embase database was performed. Retrospective and prospective studies focusing on the role of PLR on the prognosis in HCC were all deemed as “suitable” for our scope. The endpoints determined were: the overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS) and the progress free survival (PFS).ConclusionsThe study revealed that high PLR is an unfavorable predictor of OS in patients with HCC, and high PLR is a promising prognostic biomarker for HCC, especially for patients in Asia.

show abstract

Section: Discussionsupporting

confidence: 81%

“…[ 49 ] and Kabir et al . [ 21 ] both covered that PLR was not evidently associated with the RFS of HCC. However, Ji et al .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Zhao

Zhu

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…A positive association was observed between high PLR and poor prognosis in patients with transarterial chemoembolization (TACE); high PLR was also able to predict OS [ 30 , 31 ]. In another study conducted in patients who underwent surgical resection for HCC, PLR failed to predict both OS and RFS [ 32 ]. The results obtained from CHB-related HCC patients after TACE showed no evident relationship between the PLR and OS [ 33 ].…”

Section: Platelet To Lymphocyte Ratiomentioning

confidence: 99%

Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma

Aryal

Yamakuchi

Shimizu

et al. 2018

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Liver pathophysiology can, directly and indirectly, impose morphological or biochemical abnormalities of the platelets. Conversely, platelets are also able to regulate the promitogenic and profibrotic signals on liver pathobiology. Platelet contribution to the liver pathophysiology is typically facilitated by the platelet-derived growth factors that are sequestered in different subsets of alpha and dense granules, and the release of these growth factors is synchronized according to the stage and type of liver disease or injury. Thus, platelets harbor clinically relevant information with potential diagnostic and prognostic implications in liver diseases. Hepatocellular carcinoma (HCC) largely influences the platelet kinetics, and a growing body of evidence has recognized its association with HCC occurrence or prognosis. This narrative review summarizes the progress made on implicating platelet as a diagnostic and prognostic tool for HCC; the review also dissects the contradictory results from earlier studies and reflects how combining platelet-based information may enable more reliable test for diagnostic and prognostic evaluation of HCC.

show abstract

“…A possible reason is that studies enrolled patients with a different pathogenesis who received discrepant treatment. Besides, a small sample size may be another reason ( 8 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

A High Preoperative Platelet-Lymphocyte Ratio Is a Negative Predictor of Survival After Liver Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma: A Retrospective Study

et al. 2020

View full text Add to dashboard Cite

Objective: To evaluate the importance of preoperative blood platelet to lymphocyte ratio (PLR) in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after liver surgery and to examine the connection with CD8 + lymph cell infiltration. Methods: Between 2009 and 2014, consecutive HCC patients who received curative liver surgery were included into this retrospective study. Baseline clinicopathological characteristics were analyzed to identify predictors of recurrence-free and overall patient survival rate after liver resection. The samples of all patients were under Tissue Microarray (TMA) construction and immunohistochemical staining for CD8+.The association of the number of CD8+T-cells in the cancer nests and peritumoral stroma with PLR level was analyzed. Results: A total of 1,174 HBV-related HCC patients who received a liver resection without any peri-operative adjuvant therapy were enrolled into this retrospective study. Univariate and Multivariate analysis using Cox regression model showed that PLR was an independent factor affecting recurrence and overall survivals. The optimal cutoff of PLR using the receiver operating characteristic curve was 150. There were 236 patients (20.1%) who had a PLR of 150 or more. The 5-year survival rate after liver resection was 71.8% in patients with a PLR of < 150 and it was 57.2% in those with a PLR of 150 or more (P < 0.001). Both 5-year recurrence-free and overall survival rates in liver cancer stage A patients at Barcelona Clinic with different PLR group were also significantly different (P = 0.007 for recurrence and P = 0.001 for overall survival). Similar results were also observed in stage B patients (P < 0.001 for recurrence and P = 0.033 for overall survival). To determine the association between PLR and the severity of liver inflammation, an immuno-histological examination using CD8 + staining was performed on the liver specimens of 1,174 patients. Compared with low PLR (<150) group, more CD8 + T-cells were found in the peritumoral tissue in high PLR (≥ 150) group. Yang et al. Platelet-Lymphocyte Ratio and Survival Conclusions: PLR played as an independent factor for predicting the survival after hepatectomy for HCC patients. A high PLR was associated with an accumulation of CD8 + T-cells in the peritumoral stroma.

show abstract

Does preoperative platelet-lymphocyte ratio or prognostic nutritional index predict survival after surgical resection for hepatocellular carcinoma?

Cited by 3 publications

References 0 publications

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Prognostic role of platelet to lymphocyte ratio in hepatocellular carcinoma: a systematic review and meta-analysis

Deciphering Platelet Kinetics in Diagnostic and Prognostic Evaluation of Hepatocellular Carcinoma

A High Preoperative Platelet-Lymphocyte Ratio Is a Negative Predictor of Survival After Liver Resection for Hepatitis B Virus-Related Hepatocellular Carcinoma: A Retrospective Study

Contact Info

Product

Resources

About