Objective: To investigate the clinical efficacy of the cement-screw technique in repairing tibial plateau bone defects in total knee arthroplasty (TKA) recipients and summarize the preoperative prehabilitation strategies for such surgeries. Methods: A total of 33 TKA recipients (45 knees) in our department underwent repair of unilateral or bilateral tibial defects using the cement-screw technique. The subjects were divided into two groups based on the differences in preoperative interventions. The control group received routine preoperative health education according to the consensus, while the observation group received instructive and standardized prehabilitation exercises for four weeks in addition to the routine education. Scale scores, intraoperative parameters, and postoperative recovery indicators were recorded at different time pointsand subjected to statistical analysis for intra-group and inter-group differences. All subjects underwent long-term follow-up for at least 24 months. Results: Within each group at different time points, there were statistically significant differences in VAS, ROM, and HSS scores (p < 0.001). At various time points, there were statistically significant differences in VAS, ROM, and HSS scores between the two groups (p < 0.001). The observation group showed a significantly shorter time for quadriceps femoris strength recovery and discontinuation of assistive devices compared to the control group (p < 0.05). During the follow-up period (24 -30 months), no serious complications were observed. Conclusions: Cement-screw technique How to cite this paper: Zheng, W.K.,