Does preeclampsia have any adverse effect on fetal heart?

Akil, A; Api, Oluş; Can, Esra; Özkan, Sadullah; Ercan, Şerif; Orçun, Asuman; Ünal, Orhan

doi:10.3109/14767058.2015.1085013

Cited by 10 publications

(14 citation statements)

References 20 publications

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“…42 In contrast, some previous studies have evaluated fetal cardiac structure and function in PE-with and without FGR-reporting elevated myocardial performance index 43,44 and cord blood NT-proBNP and homocysteine. 45 However, the comparison among these studies is difficult, as they mostly included both FGR and non FGR cases, and a high proportion of fetuses presenting altered fetoplacental Doppler. 43e46 In contrast, we selected a unique group of PE cases with normal fetal growth using strict criteria based on fetal biometrics, confirmed birthweight, and fetoplacental Doppler.…”

Section: Results Of the Study In The Context Of Other Observationsmentioning

confidence: 99%

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction

Youssef

Miranda

Paulés

et al. 2020

American Journal of Obstetrics and Gynecology

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Section: Results Of the Study In The Context Of Other Observationsmentioning

confidence: 99%

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction

Youssef

Miranda

Paulés

et al. 2020

American Journal of Obstetrics and Gynecology

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“…Of these, 15 were included in the meta-analyses providing data on 53 029 individuals, of whom 1599 were exposed to preeclampsia in utero (Figure 2, A). 16,18,[20][21][22][24][25][26][27]34,35,37,39,41,[46][47][48] Quantitative summary measures obtained by meta-analysis demonstrate that offspring of preeclamptic pregnancies have 5.17 mm Hg (95% CI 1.60-8.73) greater SBP compared with offspring of control pregnancies (Figure 2, A). Of the 5 studies that were not included in the meta-analysis, 3 report that offspring of preeclamptic pregnancies have greater SBP compared with controls, 30,38,43 and 1 reports that offspring of term preeclamptic pregnancies have greater mean SBP compared with controls but no significant difference between offspring of preterm preeclamptic pregnancies compared with controls (Table III; available at www.jpeds.…”

Section: Systolic Blood Pressurementioning

confidence: 99%

Cardiovascular Risk Factors in Offspring of Preeclamptic Pregnancies—Systematic Review and Meta-Analysis

Andraweera

Lassi

2019

The Journal of Pediatrics

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Study design PubMed, the Cumulative Index to Nursing and Allied Health Literature, the Cochrane Library, and EMBASE electronic databases were searched with an end of search date of June 4, 2018. Prospective and retrospective studies that compared CVD risk factors in those exposed to preeclampsia in utero with controls were eligible. Information was extracted on established CVD risk factors, including blood pressure, lipid profile, blood glucose, fasting insulin, body mass index, and endothelial/microvascular function.Results Thirty-six studies provided cumulated data on 53 029 individuals. In utero exposure to preeclampsia was associated with 5.17 mm Hg (95% CI 1.60-8.73) greater mean systolic, 4.06 mm Hg (95% CI 0.67-7.44) greater mean diastolic blood pressure, and 0.36 kg/m 2 (95% CI 0.04-0.68) greater mean body mass index during childhood or young adulthood. No significant association was seen between exposure to preeclampsia in utero and other CVD risk factors.Conclusions Offspring of preeclamptic pregnancies demonstrate risk factors for CVD during childhood and young adult life. Early blood pressure screening of children born after preeclamptic pregnancies may identify those that require interventions or preventive strategies to reduce later life CVD risk.

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“…The presence of this dysfunction is further supported by the finding of an elevation in the levels of certain cardiac enzymes at birth [2]. In addition, infants born SGA exhibit significantly reduced LV GLS (-15.9 vs. -21.3%) compared to appropriately grown infants during the early neonatal period, and this has been related to the degree of arterial stiffness [22].…”

Section: Discussionmentioning

confidence: 66%

“…In addition, an abnormal intra-uterine environment can have a direct effect on the cardiovascular well-being of infants in the immediate post-natal period [1]. Maternal PE results in increased natriuretic peptide and homocysteine in neonates (suggesting abnormal myocardial function) [2], and children born to mothers with PE have altered cardiac profiles compared with controls when assessed using echocardiography at 5-8 years of age [3]. In addition, IUGR infants demonstrate altered cardiac morphology and reduced myocardial function in the first week of life [4].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Maternal Gestational Hypertension and the Use of Anti-Hypertensives on Neonatal Myocardial Performance

Breatnach¹,

Monteith²,

McSweeney³

et al. 2017

Neonatology

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Background: Assessment of myocardial performance in neonates using advanced techniques such as deformation imaging and rotational mechanics has gained considerable interest. The applicability of these techniques for elucidating abnormal myocardial performance in various clinical scenarios is becoming established. We hypothesise that term infants born to mothers with gestational hypertension (GH) may experience impaired performance of the left and right ventricles during the early neonatal period. Objectives: We aimed to assess left and right ventricular (LV and RV) function using echocardiography in infants born to mothers with GH and compare them to a control group. Methods: Term infants (>36⁺⁶ weeks) born to mothers with GH underwent assessment to measure biventricular function using ejection fraction (EF), deformation imaging, left-ventricle rotational mechanics (apical rotation, basal rotation, twist, twist rate, and untwist rate), and right ventricle-specific functional parameters (tricuspid annular plane systolic excursion and fractional area change) in the first 48 h after birth. A control group comprising infants born to healthy mothers was used for comparison. Results: Fifteen infants with maternal GH and 30 age-matched controls were enrolled. The GH infants exhibited no differences in birthweight or LV or RV length, but they had lower EF (54 vs. 61%; p < 0.01), LV global longitudinal strain (-20 vs. -25%; p < 0.01), and LV twist (11 vs. 16°; p = 0.04). There were no differences in any of the RV functional parameters. Conclusion: Infants born to mothers with GH exhibited lower LV function than healthy controls, while RV function appeared to be preserved. This relationship warrants further exploration in a larger cohort.

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Does preeclampsia have any adverse effect on fetal heart?

Cited by 10 publications

References 20 publications

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction

Cardiovascular Risk Factors in Offspring of Preeclamptic Pregnancies—Systematic Review and Meta-Analysis

The Impact of Maternal Gestational Hypertension and the Use of Anti-Hypertensives on Neonatal Myocardial Performance

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