Does polydeoxyribonucleotide has an effect on patients with tendon or ligament pain?

Abstract

Background: Pain in the tendons or ligaments is extremely common, accounting for 30% of the causes of visiting general practitioners. Polydeoxyribonucleotide (PDRN) is emerging as a new treatment for musculoskeletal pain. However, the effects of PDRN in patients with tendon or ligament pain are unclear. Therefore, this study aimed to determine the impact of PDRN in patients with tendon or ligament pain through a meta-analysis. Methods: Electronic literature search of PubMed, Embase, SCOPUS, and Cochrane Library databases of all articles on PDRN treatment for patients with tendon or ligament pain published in the English language from inception until January 31, 2020. The search identified 262 citations. Results: One randomized controlled trial and 3 retrospective observational studies were included. Pain due to tendon or ligament disorders showed significant improvement after PDRN injection (standardized mean difference [SMD] = −1.43, 95% confidence interval [CI] = −1.80 to −1.06, P < .00001). In the subanalysis of patients with rotator cuff tendinopathy, rotator cuff tendinopathy-induced pain significantly improved (SMD = −2.34, 95% CI = −3.61 to −1.07, P = .0003) after PDRN injection. However, there was no difference in shoulder pain and disability index score and strength of shoulder abduction in patients with rotator cuff tendinopathy (shoulder pain and disability index score, SMD = 1.16, 95% CI = −1.20 to 3.52, P = .34; strength of shoulder abduction, SMD = 0.42, 95% CI = −0.03 to 0.88, P = .07). Conclusion: Effective pain relief was achieved in patients with tendon or ligament disorders after PDRN injection. To more precisely determine this effect, a meta-analysis with a larger number of clinical trials is warranted.

Partial-thickness rotator cuff tears: a review of current literature on evaluation and management

“…Polydeoxyribonucleotide (PDRN) is an emerging treatment that has been found to significantly reduce musculoskeletal pain associated with rotator cuff tendinopathy [ 40 ]. PDRN is a compound formed by deoxyribonucleotide polymers of varying lengths of base pairs and nucleosides derived from salmon sperm [ 41 ].…”

Exploring the Effects of 630 nm Wavelength of Light-Emitting Diode Irradiation on the Proliferation and Migration Ability of Human Biceps Tendon Fibroblast Cells

“…In the treatment of degenerative tendinopathy or after tendon repair surgery, it is important to enhance healing and regeneration. For this, various methods, such as extracorporeal shockwave therapy, 3) prolotherapy, 4) platelet-rich plasma injections, 5) stem cell therapy, 6) polydeoxyribonucleotide, 7) and atelocollagen treatments, 8) have been attempted, each with its own rationale. In addition, the biologics of bioaugmentation methods, such as mesenchymal stem cells and growth factors, are being introduced for tissue healing during tendon surgery.…”