Does platelet-rich fibrin increase stability of the maxilla following Le Fort I osteotomy? A single-blind clinical trial study

Sadeghi, Hassan Mir Mohammad; Bakhshaei, Pedram; Özkan, Birkan Taha

doi:10.1016/j.jcms.2020.04.007

Cited by 8 publications

(9 citation statements)

References 24 publications

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“…Only studies that were published within 3 years of the search date were included ( n = 60). After duplicate removal and screening, 50 articles were included in the analysis 35‐84 (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…42 Similarly, an unblinded study favoured L-PRF membranes over collagen membranes as a dressing for excision wound sites but was also judged to be at high risk of bias. 65 Tabrizi et al conducted two similar studies, 45,53 focussing on Le Fort I osteotomy and bilateral sagittal-split osteotomy, respectively. In both cases, PRF application was associated with significant clinical improvealthough neither study was judged to be at low risk of bias.…”

Section: Oral Surgery (Extractions Socket Preservation and Implant Pl...mentioning

confidence: 99%

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What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

Savva

2022

Oral Surgery

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Background Platelet‐rich fibrin (PRF) is a second‐generation platelet concentrate and biomaterial with multiple applications in clinical dentistry. Recent developments in the production of PRF have resulted in several divergent protocols that could be seen to affect the reproducibility and generalisability of the available literature. Additionally, imprecise reporting on PRF production is a further confounding factor with respect to previous trial data. Aims The primary aim of this review was to assess the recent clinical trial data relating to the use of PRF, irrespective of centrifugal protocol, in clinical dentistry. Methods A systematic literature review was carried out in PubMed and the Cochrane Library databases to select English language, human clinical trials involving the use of PRF published between July 2018 and July 2021. Results The 50 included studies demonstrated an overall clinical benefit for the use of PRF in the fields of oral medicine, oral surgery and periodontology, with unclear benefits in the field of endodontology, and no clear benefit in the field of orthodontics. Only 16% of the included studies met published standards for reporting PRF production protocols, and meeting such standards should be an essential requirement for future publications. Conclusions There was little direct evidence to support one particular PRF protocol over another and this remains an area of controversy. Future research should focus on precise reporting of PRF protocols, and in areas where PRF is of known benefit, the use of different production methods should be compared to assess what, if any, clinical significance is attached to particular centrifugation protocols and tubes.

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Section: Resultsmentioning

confidence: 99%

Section: Oral Surgery (Extractions Socket Preservation and Implant Pl...mentioning

confidence: 99%

What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

Savva

2022

Oral Surgery

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“…In the last decade, between 2012 and 2022, the greatest number of studies on PRF clinical applications published in the PubMed database were done in the field of oral and maxillofacial surgery, dealing with various diseases, injuries, and defects in the oral cavity, jaws, face, and neck. PRF use was described in alveolar ridge preservation [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ], orthognathic surgery [ 33 , 34 ], cleft lip and palate surgery [ 35 , 36 ], maxillary sinus augmentation [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], and dental implant placement [ 24 , 45 , 46 , 47 , 48 , 49 ]. It showed the ability to accelerate the closure of an extraction socket, improve periodontal status, reduce postoperative pain sensation and swelling, accelerate neurosensory recovery, reduce bone resorption, increase and accelerate bone formation, enhance bone stability after surgery, and provide faster dental implant osseointegration as well as increased dental implant stability ( Figure 1 ).…”

Section: Prf Clinical Application In Oral and Maxillofacial Surgerymentioning

confidence: 99%

“…Despite rigid fixation of the bones using titanium miniplates and screws, bony tissue relapse may occur in the postoperative period, especially in the long term. If the size of the gap between the osteotomy segments is larger than 3 mm, then bone healing tends to be inadequate, which may result in impaired hard tissue formation that replaces it with fibrotic tissue [ 33 ]. A higher relapse rate is reported in unilateral cleft lip and palate patients and those who underwent bimaxillary surgery [ 55 ].…”

Section: Prf Clinical Application In Oral and Maxillofacial Surgerymentioning

confidence: 99%

“…A higher relapse rate is reported in unilateral cleft lip and palate patients and those who underwent bimaxillary surgery [ 55 ]. In such cases, the use of bone grafts should be considered [ 33 ]. Another complication that can occur after orthognathic surgery is a neurosensory disturbance (NSD).…”

Section: Prf Clinical Application In Oral and Maxillofacial Surgerymentioning

confidence: 99%

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Can Our Blood Help Ensure Antimicrobial and Anti-Inflammatory Properties in Oral and Maxillofacial Surgery?

Micko

Šalma

Skadiņš

et al. 2023

IJMS

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In recent decades, the potential of PRF has been extensively studied. The number of studies about PRF has increased three times since the year 2012, but the full spectrum of its fundamental properties, such as antimicrobial and anti-inflammatory activity, is not clearly described. In oral and maxillofacial surgery, PRF is described in alveolar ridge preservation, orthognathic surgery, cleft lip and palate surgery, maxillary sinus augmentation, and dental implant placement as demonstrating favorable results and its clinical advantages. The structural complexity, inhomogeneous nature, and clotting ability of PRF make its antimicrobial effect evaluation complicated. Nevertheless, most of the used antimicrobial testing methods are based on antibacterial agent diffusion ability in culture media. Because the oral and maxillofacial region is the most frequent area of PRF application, its antimicrobial activity evaluation also prevails in the oral microbiome. PRF’s biological potential is highly dependent on the specific preparation protocol and methodology used; it should be carefully prepared and kept under proper conditions to keep cellular content alive. PRF’s influence on living cells demonstrates a stimulating effect on bone regeneration, and an angiogenetic effect, and it provides anti-inflammatory activity. According to analyzed studies, PRF demonstrated success in oral and maxillofacial surgery in various methods of application. Antibacterial and anti-inflammatory properties were proven by antibacterial activity against different bacterial species, sustained growth factor, sustained release, and cell activity on the material application. Accurately and correctly prepared PRF can ensure antibacterial and anti-inflammatory properties, and it can be a beneficial clinical tool in oral and maxillofacial surgery.

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Comprehensive evaluation of advanced platelet-rich fibrin in common complications following sagittal split ramus osteotomy: a double-blind, split-mouth, randomized clinical trial

Zhu,

Sun,

Chen

et al. 2024

International Journal of Oral and Maxillofacial Surgery

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Does platelet-rich fibrin increase stability of the maxilla following Le Fort I osteotomy? A single-blind clinical trial study

Cited by 8 publications

References 24 publications

What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

What recent evidence exists to support the use of platelet‐rich fibrin in clinical dentistry? A systematic literature review

Can Our Blood Help Ensure Antimicrobial and Anti-Inflammatory Properties in Oral and Maxillofacial Surgery?

Comprehensive evaluation of advanced platelet-rich fibrin in common complications following sagittal split ramus osteotomy: a double-blind, split-mouth, randomized clinical trial

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