Does Persistent Inflammatory Catabolic Syndrome Exist in Critically Ill Neonates?

Ellis, Nicole; Hughes, Caitlin; Mazurak, Vera C.; Joynt, Chloë; Larsen, Bodil

doi:10.1177/0148607116672621

Cited by 5 publications

(9 citation statements)

References 15 publications

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“…There is evidence of an association among malnutrition, increased risk of inflammation, and loss of myocardial muscle . Ellis et al described persistent inflammatory catabolic syndrome in cardiac surgical infants and found that it significantly impaired growth velocity . Infants included in the study were able to achieve only 75% of their expected weight gain, and half were classified as failure to thrive .…”

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

“…Ellis et al described persistent inflammatory catabolic syndrome in cardiac surgical infants and found that it significantly impaired growth velocity . Infants included in the study were able to achieve only 75% of their expected weight gain, and half were classified as failure to thrive . Growth may also be compromised by intestinal malabsorption and dysfunction .…”

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

“…Total energy expenditure (TEE) includes basal metabolic rate (BMR) and energy expended for thermoregulation, physical activity, and growth . BMR is a chief component of TEE and is used for the maintenance of basic life functions, such as heart function, breathing, and basic cellular function . In the hemodynamic model of a child with HF, stroke volume is low; heart rate is high; and work of the heart is increased, contributing to an increased BMR .…”

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

“…21 Infants included in the study were able to achieve only 75% of their expected weight gain, and half were classified as failure to thrive. 21 Growth may also be compromised by intestinal malabsorption and dysfunction. 22 Chronic hypoxia and gut edema from venous congestion can lead to insufficient utilization of nutrients and malabsorption.…”

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

“…22 BMR is a chief component of TEE and is used for the maintenance of basic life functions, such as heart function, breathing, and basic cellular function. 21 In the hemodynamic model of a child with HF, stroke volume is low; heart rate is high; and work of the heart is increased, contributing to an increased BMR. 22 Increased work of breathing increases stimulation of the sympathetic nervous system and contributes to increased BMR and TEE in children with heart disease.…”

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

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Optimizing Nutrition in Pediatric Heart Failure: The Crisis Is Over and Now It’s Time to Feed

et al. 2017

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Pediatric heart failure is a complex disease occurring when cardiac output is unable to meet the metabolic demands of the body. With improved surgical interventions and medical therapies, survival rates have improved, and care has shifted from focusing on survival to optimizing quality of life and health outcomes. Based on current literature, this review addresses the nutrition needs of infants and children in heart failure and describes the pathophysiology and metabolic implications of this disease. The prevalence of wasting in pediatric heart failure has been reported to be as high as 86%, highlighting the importance of nutrition assessment through all stages of treatment to provide appropriate intake of energy, protein, and micronutrients. The etiology of malnutrition in pediatric heart failure is multifactorial and involves hypermetabolism, decreased intake, increased nutrient losses, inefficient utilization of nutrients, and malabsorption. Children in heart failure often present with tachypnea, tachycardia, fatigue, nausea, and vomiting and consequently may not be able to meet their nutrition requirements through oral intake alone. Nutrition support, including enteral nutrition and parenteral nutrition, should be considered an essential part of routine care. The involvement of multiple allied health professionals may be needed to create a feeding therapy plan to support patients and their families. With appropriate nutrition interventions, clinical outcomes and quality of life can be significantly improved.

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Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

Section: Pathophysiology Of Malnutrition In Pediatric Hfmentioning

confidence: 99%

See 3 more Smart Citations

Optimizing Nutrition in Pediatric Heart Failure: The Crisis Is Over and Now It’s Time to Feed

et al. 2017

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Exploring Growth Failure in Neonates With Enterostomy

Davidson,

Omran,

Chong

et al. 2024

Journal of Pediatric Surgery

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Cohort study showed that growth rate increment has not been enough to prevent growth retardation of preterm infants and raised concerns about unbalanced growth

et al. 2019

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Aim: We describe the postnatal weight gain, linear and head growth trends of surviving preterm infants from 2005 to 2017.Methods: Multicentre cohort study, including surviving preterm infants <32 weeks (n = 21 084), from the Spanish Neonatal Network database, without major congenital malformations who were less than 50 weeks postmenstrual age at discharge. Outcomes were weight gain (g/kg/day), linear and head growth (cm/week) and changes in weight, length and head circumference z-scores from birth to discharge. The study period was divided into Results: Weight gain, linear growth and head growth were slightly higher in 2015-2017 than in 2005-2008: 12.2 AE 2.6 to 13.1 AE 2.5 g/kg/day, 0.98 AE 0.6 to 1.03 AE 0.6 cm/ week and 0.76 AE 0.2 to 0.77 AE 0.3 cm/week, respectively. It was associated with a decreased fall in weigh, length and head circumference z-scores from birth to discharge (À1.32 AE 0.9 to À1.01 AE 0.84, À1.38 AE 1.2 to À1.18 AE 1.2 and À0.41 AE 1.2 to À0.33 AE 1.3, respectively).Conclusion: Postnatal growth restriction remained a common complication of prematurity despite some increment over the last years. Growth disproportionality seemed to be worsening as weight gain was increased more than linear growth.

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Does Persistent Inflammatory Catabolic Syndrome Exist in Critically Ill Neonates?

Cited by 5 publications

References 15 publications

Optimizing Nutrition in Pediatric Heart Failure: The Crisis Is Over and Now It’s Time to Feed

Optimizing Nutrition in Pediatric Heart Failure: The Crisis Is Over and Now It’s Time to Feed

Exploring Growth Failure in Neonates With Enterostomy

Cohort study showed that growth rate increment has not been enough to prevent growth retardation of preterm infants and raised concerns about unbalanced growth

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