Does Periodontitis Reflect Inflammation and Malnutrition Status in Hemodialysis Patients?

Chen, Liping; Chiang, Chih‐Kang; Chan, Chiu‐Po; Hung, Kuan‐Yu; Huang, Chiung-Shing

doi:10.1053/j.ajkd.2006.01.018

Cited by 142 publications

(176 citation statements)

References 25 publications

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“…Recent reports demonstrate a high prevalence of inflammation (5,7,8) among individuals with ESKD. A notable recent study of hemodialysis patients in Taipei, Taiwan, demonstrated a similar relationship of periodontal disease and serum albumin (16). The key similarity to our study was that serum albumin concentration was inversely related to the severity of periodontal disease.…”

Section: Discussionsupporting

confidence: 61%

“…First, the cross-sectional study design prevents us from determining the exact nature of the observed association. Initial cross-sectional findings, such as ours, are based on current knowledge of the literature and are useful for generating hypotheses, yet the recent article by Chen et al (16) strongly suggests that our results were not isolated findings. We acknowledge that the association could be due to uncontrolled confounding by socioeconomic factors or by other unmeasured conditions.…”

Section: Discussionmentioning

confidence: 72%

“…Recent evidence suggests a high prevalence of periodontitis among individuals at early stages of CKD (9,10) and at end-stage kidney disease (11)(12)(13)(14)(15)(16) …”

mentioning

confidence: 99%

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Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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The relationship between periodontitis and two measures of systemic inflammation, serum albumin and C-reactive protein (CRP), were examined among patients who were receiving chronic outpatient hemodialysis. Adult patients at two locations, North Carolina and New York City, were evaluated by dentist examiners. Six sites per tooth (up to 32 teeth per patient) were examined. A periodontitis case was defined as >60% of sites with attachment level >4 mm. Multivariable logistic regression was used to determine the association of periodontitis with low serum albumin, defined as <3.5 mg/dl, and with high CRP, defined as >3.0 mg/dl. A total of 154 patients completed the study. The mean age was 54.6 yr (SD 13.3), and average duration of dialysis was 4.0 yr (3 mo to 16 yr). Eighty-six (54.6%) were men, and 89 (58.2%) were black. Common causes of end-stage kidney disease were hypertension (12.3%), diabetes (22.1%), glomerulonephritis (7.1%), and other (58.4%). The average number of teeth was 20.3 (SD 8.4). Thirty-five (23%) patients were periodontitis cases. Severe periodontitis was associated with low serum albumin (odds ratio 8.20; 95% confidence interval 1.61 to 41.82; P ‫؍‬ 0.01) compared with individuals without severe periodontitis disease after adjustment for age, gender, race, diabetes, hypertension, body mass index, smoking, study site, total cholesterol, serum calcium, serum phosphorus, and normalized protein catabolic rate. There was no observed association of severe periodontitis with CRP. Investigation of the potential contribution of periodontitis to serum albumin and possibly to morbidity and mortality among patients with end-stage kidney disease seems warranted.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 72%

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Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Kshirsagar

Craig

Beck

et al. 2007

Clinical Journal of the American Society of Nephrology

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“…Evidências revelam que a população em HD possui um pobre padrão de higiene oral (HO) e condição periodontal ruim (Naugle et al, 1998;Chen et al, 2006;Klassen;Krasko, 2002;Souza et al, 2005;Bots et al, 2006;Bayraktar et al, 2007;Cengiz et al, 2007;Xie et al, 2014). Algumas publicações ainda demonstraram que os indivíduos em HD, em comparação aos que realizam diálise peritoneal, também apresentam mais DP (Bots et al, 2006;Bayraktar et al, 2008;Brito et al, 2012).…”

Section: Lista De Tabelasunclassified

“…A uremia está associada à disfunção na resposta inata e adaptativa do hospedeiro, incluindo diminuição da atividade das células T e B, além de defeitos na função de neutrófilos e monócitos (Cohen et al, 1997;Eleftheriadis et al, 2007;Kato et al, 2008;Stinghen et al, 2010). Devido a isso, alguns estudos sugerem que pacientes que realizam HD há mais tempo têm mais DP (Duran;Erdemir, 2004;Davidovich et al, 2005;Chen et al, 2006;Bayraktar et al, 2007;Sekiguchi et al, 2012). Entretanto, há divergências quanto a este assunto, pois diversas pesquisas não encontraram tal relação (Naugle et al, 1998;Al-Wahadni;Al-Omari, 2003;Marakoglu et al, 2003;Bots et al, 2006).…”

Section: Lista De Tabelasunclassified

Prevalência da doença periodontal em pacientes com doença renal crônica em hemodiálise

Possamai¹

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Nutritional Disorders in Chronic Kidney Disease

Molina

Vizcaíno

Huarte

et al. 2022

Evidence‐Based Nephrology

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Does Periodontitis Reflect Inflammation and Malnutrition Status in Hemodialysis Patients?

Cited by 142 publications

References 25 publications

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Severe Periodontitis Is Associated with Low Serum Albumin among Patients on Maintenance Hemodialysis Therapy

Prevalência da doença periodontal em pacientes com doença renal crônica em hemodiálise

Nutritional Disorders in Chronic Kidney Disease

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