Does Pattern Scan Laser (PASCAL) photocoagulation really induce less VEGF expression in murine retina than conventional laser treatment?

Konac, Ece; Sönmez, Kenan; Bahçelioğlu, Meltem; Kaplanoğlu, Gülnur Take; Varol, Nuray; Sarac, Gulce Naz; Özcan, Yasin

doi:10.1016/j.gene.2014.07.062

Cited by 3 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pigment epithelium-derived factor, which can inhibit retinal and choroidal neovascularization by inducing apoptosis in activated vascular endothelial cells, is reported to be upregulated in photocoagulated human retinal pigment epithelial cells [157, 158]. VEGF expression is found to increase a few days after laser treatment and then start to decrease [159]. Moreover, direct photocoagulation to leaking vessels and microaneurysms is found to be beneficial for treating chronic macular edema associated with chronic BRVO of longer than 12 months duration [160].…”

Section: Treatmentmentioning

confidence: 99%

New Developments in the Classification, Pathogenesis, Risk Factors, Natural History, and Treatment of Branch Retinal Vein Occlusion

Paulus

Shuai

et al. 2017

Journal of Ophthalmology

View full text Add to dashboard Cite

For years, branch retinal vein occlusion is still a controversial disease in many aspects. An increasing amount of data is available regarding classification, pathogenesis, risk factors, natural history, and therapy of branch retinal vein occlusion. Some of the conclusions may even change our impression of branch retinal vein occlusion. It will be beneficial for our doctors to get a deeper understanding of this disease and improve the treatment skills. The aims of this review is to collect the information above and report new ideas especially from the past a few years.

show abstract

Section: Treatmentmentioning

confidence: 99%

New Developments in the Classification, Pathogenesis, Risk Factors, Natural History, and Treatment of Branch Retinal Vein Occlusion

Paulus

Shuai

et al. 2017

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…After an initial increase in VEGF expression due to inflammation, the injured RPE cells surrounding the laser spots release cytokines that inhibit neovascularization and endothelial cell growth. [6][7][8] Apart from in vitro experiments and histology studies, the effect of laser treatment has been extensively studied in vivo. The retina is relatively easily accessible with standard and advanced imaging methods.…”

mentioning

confidence: 99%

Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Karst

Beiglboeck

Scharinger

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

Citation: Karst SG, Beiglboeck H, Scharinger R, et al. Retinal and choroidal perfusion status in the area of laser scars assessed with swept-source optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2019;60:4865-4871. https://doi.org/ 10.1167/iovs.19-27977PURPOSE. To evaluate the perfusion status of the retina and choriocapillaris in the area of laser scars on swept-source optical coherence tomography angiography (OCTA) images of eyes previously treated with panretinal photocoagulation (PRP). METHODS.Cross-sectional exploratory analysis of swept-source OCTA images, which were retrospectively reviewed for laser scars. The appearance of the capillary networks in the area of previous laser were evaluated following a three-step grading system (normal/sparse/ missing capillary network). The superficial and deep capillary plexus of the retina and the choriocapillaris were graded separately. RESULTS.A total of 3140 laser scars in 54 eyes of 31 patients (13 female, mean age 57 6 12 years) were included in this analysis. In the retina, 6.8% of the superficial and deep capillary network in the area evaluated appeared normal, 58% and 56% sparse, and 35% and 37% missing. Capillary dropout in the retina was not restricted to the area of prior laser treatment. The choriocapillaris decorrelation signal was either sparse (61%) or completely missing (38%) within the laser scar area. The perfusion of the choriocapillaris appeared normal in the area adjacent to laser scars.CONCLUSIONS. Capillary non-perfusion in the choriocapillaris was found within the laser scar area. Laser treatment seems to cause sustained non-perfusion of choriocapillaris in the area treated.

show abstract

“…A randomized clinical trial demonstrated that grid laser treatment is helpful in improving visual acuity in eyes with ME [18],but the results achieved are modest. Furthermore, one study on murine retina showed that VEGF protein level is found to increase a few days after laser treatment and then start to decrease in mouse eyes [19].So the laser treatment seems did not bene t in BCVA and resolution of edema. Most of the current studies still support vitreous injection.…”

Section: Discussionmentioning

confidence: 99%

Conbercept Versus Conbercept Combined with Retinal Photocoagulation for Macular Edema Secondary to Branch Retinal Vein Occlusion

Tong

Wang

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: To evaluate the efficacy of intravitreal injection of conbercept (IVC) with or without laser photocoagulation for recurrent macular edema secondary to branch retinal vein occlusion (BRVO). Methods: 82 patients (82 eyes) with recurrent macular edema secondary to BRVO were collected. The central macular thickness (CMT) and best corrected visual acuity (BCVA) were recorded. Results: The BCVA in both groups was significantly superior to that before treatment (P<0.05). Compared with initial values, CMT was reduced significantly in both groups (P<0.05). But at 1 month to 6 month after treatment, there are no significant difference was observed between the two groups (P>0.05). In the combined therapy group for Hemispheric Retinal Vein Occlusion, we observed a lower number of reinjections during follow-up. Conclusion: Conbercept with or without retinal photocoagulation can effectively improve the visual acuity and reduce the CMT.

show abstract

Does Pattern Scan Laser (PASCAL) photocoagulation really induce less VEGF expression in murine retina than conventional laser treatment?

Cited by 3 publications

References 18 publications

New Developments in the Classification, Pathogenesis, Risk Factors, Natural History, and Treatment of Branch Retinal Vein Occlusion

New Developments in the Classification, Pathogenesis, Risk Factors, Natural History, and Treatment of Branch Retinal Vein Occlusion

Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Conbercept Versus Conbercept Combined with Retinal Photocoagulation for Macular Edema Secondary to Branch Retinal Vein Occlusion

Contact Info

Product

Resources

About