Does pattern electroretinogram spatial tuning alteration in Parkinson's disease depend on motor disturbances or retinal dopaminergic loss?

Peppe, Antonella; Stanzione, Paolo; Pierantozzi, Mariangela; Semprini, Roberta; Bassi, Andrea; Santilli, Antonella; Formisano, Rita; Piccolino, Marco; Bernardi, Giorgio

doi:10.1016/s0013-4694(97)00075-8

Cited by 56 publications

(33 citation statements)

References 41 publications

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“…In particular, akinesia and rigidity (Lindemberg, 1964;Jellinger, 1966) are common symptoms and may be secondary to multiple lesions either in the substantia nigra or in the caudate-putamen area (Morsier, 1960;Nayernouri, 1985). It should be noted that motor disabilities in this population are the consequence of traumatic lesions at the level of the extrapyramidal pathway and not the effect of systemic dopaminergic degeneration (Peppe et al, 1998). Indeed, our young patients' history was unremarkable; no extrapyramidal symptoms were reported before the brain injury.…”

Section: Discussionmentioning

confidence: 98%

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Russo

Incoccia

Formisano

et al. 2005

Journal of Neurotrauma

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Movement-related cortical potentials (MRCPs) were examined in seven patients with severe traumatic brain injury (TBI) and 12 matched control subjects. All patients had clinically established good recovery by the time of testing. Flexion movements of the index finger of the left or right hand were recorded in two (alternating and repetitive) self-paced conditions and in one externally triggered condition. In control subjects, the bereitschaftspotential (BP) component of MRCP was detected approximately 2000 msec prior to movement onset in the self-paced conditions and was larger and earlier in the alternating compared to the repetitive condition. The BP component was absent in the externally triggered condition. In TBI patients, the BP was greatly reduced and no difference between the alternating-repetitive conditions was detected; in contrast, only small differences were present in the controls for the negative slope (NS) and MP components and no difference for the reafferent positivity (RAP) component. A dipole analysis indicated the supplementary motor area and the premotor area as the likely generators of BP and NS components, respectively. Gradientrecalled echo magnetic resonance imaging allowed the detection of a number of small hypointense lesions primarily located in the frontal lobes, as in diffuse axonal injury. This pattern of results indicates a selective deficit in motor preparation and a relatively spared pattern of activation during and following movement in these patients. Imaging data appear generally consistent with the pattern of MRCPs observed in the patient group. Implications of these results for the problem of slowness in TBI patients are discussed.

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Section: Discussionmentioning

confidence: 98%

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Russo

Incoccia

Formisano

et al. 2005

Journal of Neurotrauma

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“…To evaluate dopaminergic retinal function and to show the correlation between dopaminergic neuronal loss and the clinical stage of the disease Tagliati M and coworkers have used pattern electroretinogram (PERG) and PERG spatial tuning ratio. In human and animal studies in PD a relationship between retinal alteration and dopaminergic retinal function loss has been established [29][30][31]. Dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo marker of nigrostriatal neuron loss in Parkinson's disease (PD).…”

Section: Discussionmentioning

confidence: 99%

Correlation between retinal morphological and functional findings and clinical severity in Parkinson’s disease

et al. 2007

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“…In addition, in children with phenylketonuria who experienced very high phenylalanine levels in the first postnatal days, and who should therefore have particularly low levels of dopamine in the retina, visual acuity is lower than in normal ones (Munakata et al, 2004). Furthermore, a reduction in retinal dopamine, as occurs in parkinsonian patients, results in reduced retinal spatial resolution (Peppe et al, 1998).…”

Section: Role Of Dopaminergic Amacrine Cells In Retinal Maturation Inmentioning

confidence: 99%

Setting the Pace for Retinal Development: Environmental Enrichment Acts Through Insulin-Like Growth Factor 1 and Brain-Derived Neurotrophic Factor

Landi

Ciucci²,

Maffei³

et al. 2009

J. Neurosci.

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Environmental enrichment strongly affects visual system maturation both at retinal and cortical levels. Which molecular pathways are activated by an enriched environment (EE) to regulate visual system development has not been clarified. Here, we show that early [postnatal day 1 (P1) to P7] insulin-like growth factor 1 (IGF-1) injections in the eyes of non-EE rat pups mimic EE effects both in increasing BDNF levels in the retinal ganglion cell layer at P10 and in determining a more adult-like retinal acuity, assessed with pattern electroretinogram at P25. Blocking IGF-1 action in EE animals during the same early postnatal time window by injecting the IGF-1 receptor antagonist JB1 prevents EE effects both on BDNF expression and on retinal acuity maturation. Reducing BDNF expression in the retina of IGF-1-treated rats prevents IGF-1 effects on retinal acuity development. Finally, we show that tyrosine hydroxylase (TH) expression is increased in the retina of P10 EE and IGF-1-treated rats and that blocking TH expression in EE animals prevents EE from affecting retinal acuity development. Thus, early levels of IGF-1 play a key role in mediating EE effects on retinal development through an action that requires BDNF and involves dopaminergic amacrine cell network.

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Does pattern electroretinogram spatial tuning alteration in Parkinson's disease depend on motor disturbances or retinal dopaminergic loss?

Cited by 56 publications

References 41 publications

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Abnormal Motor Preparation in Severe Traumatic Brain Injury with Good Recovery

Correlation between retinal morphological and functional findings and clinical severity in Parkinson’s disease

Setting the Pace for Retinal Development: Environmental Enrichment Acts Through Insulin-Like Growth Factor 1 and Brain-Derived Neurotrophic Factor

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